Empirical Formula: C10H24NO3PS
Molecular Weight: 269.3412 g/mol
Index of Refraction: 1.471
Density: 1.07 g/cm3
Flash Point: 144.3 °C
Enthalpy of Vaporization: 55.63 kJ/mol
Boiling Point: 315.1 °C at 760 mmHg
Vapour Pressure: 0.000448 mmHg at 25 °C
Structure of Amiton (CAS NO.78-53-5):
IUPAC Name of Amiton (CAS NO.78-53-5): 2-Diethoxyphosphorylsulfanyl-N,N-diethylethanamine
Amiton (CAS NO.78-53-5) can be used as an acaricide and insecticide.
Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
---|---|---|---|---|---|
guinea pig | LD50 | subcutaneous | 80ug/kg (0.08mg/kg) | Canadian Journal of Physiology and Pharmacology. Vol. 46, Pg. 109, 1968. | |
hamster | LD50 | subcutaneous | 210ug/kg (0.21mg/kg) | Canadian Journal of Physiology and Pharmacology. Vol. 46, Pg. 109, 1968. | |
mouse | LD50 | intraperitoneal | 300ug/kg (0.3mg/kg) | Journal of Agricultural and Food Chemistry. Vol. 12, Pg. 53, 1964. | |
mouse | LD50 | subcutaneous | 190ug/kg (0.19mg/kg) | Canadian Journal of Physiology and Pharmacology. Vol. 46, Pg. 109, 1968. | |
rabbit | LD50 | subcutaneous | 125ug/kg (0.125mg/kg) | Canadian Journal of Physiology and Pharmacology. Vol. 46, Pg. 109, 1968. | |
rat | LD50 | intraperitoneal | 600ug/kg (0.6mg/kg) | Advances in Pest Control Research. Vol. 4, Pg. 117, 1961. | |
rat | LD50 | oral | 3300ug/kg (3.3mg/kg) | Agricultural Research Service, USDA Information Memorandum. Vol. 20, Pg. 7, 1966. | |
rat | LD50 | subcutaneous | 150ug/kg (0.15mg/kg) | Canadian Journal of Physiology and Pharmacology. Vol. 44, Pg. 745, 1966. |
EPA Extremely Hazardous Substances List.
A deadly poison by ingestion and subcutaneous routes. A cholinesterase inhibitor. An insecticide. See also PARATHION. When heated to decomposition it emits very toxic fumes of NOx, POx, and SOx.
Amiton ,its cas register number is 78-53-5. It also can be called Tetram ; VG (O,O-Diethyl- S- [2- (diethylamino)ethyl] phosphorothioate) ; O,O-Diethyl S-(b-Diethylamino)ethyl Phosphorothiolate ; Thiophosphate de S-[2-(diéthylamino)éthyle] et de O,O-diéthyle ;and S-[2-(Diethylamino)ethyl]-O,O-diethylthiophosphat . It is highly toxic orally. Amiton (CAS NO.78-53-5) is a cholinesterase inhibitor, and is now considered too dangerous for use in agriculture but unlike other nerve agents it is classified under Schedule 2 of the Chemical Weapons Convention rather than the more restrictive Schedule 1. It was the trade name for the substance when it was marketed as an insecticide by ICI in the mid-1950s, and was described in a 1955 paper by Ghosh and another chemist, J. F. Newman, as being particularly effective against mites. It was brought to market as an insecticide by the company in 1954 but was subsequently withdrawn as too toxic.
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