Product Name

  • Name

    S-[2-(Diethylamino)ethyl]O,O-diethylphosphorothioate

  • EINECS
  • CAS No. 78-53-5
  • Article Data14
  • CAS DataBase
  • Density 1.070±0.06 g/cm3(Predicted)
  • Solubility
  • Melting Point 25°C
  • Formula C10H24 N O3 P S
  • Boiling Point bp0.01 76°; bp0.2 110°
  • Molecular Weight 269.345
  • Flash Point 144.3oC
  • Transport Information
  • Appearance
  • Safety A deadly poison by ingestion and subcutaneous routes. A cholinesterase inhibitor. An insecticide. See also PARATHION. When heated to decomposition it emits very toxic fumes of NOx, POx, and SOx.
  • Risk Codes
  • Molecular Structure Molecular Structure of 78-53-5 (S-[2-(Diethylamino)ethyl]O,O-diethylphosphorothioate)
  • Hazard Symbols Cholinesterase inhibitor. Use may be restricted.
  • Synonyms Amiton;DSDP; Inferno; Metramac; O,O-Diethyl S-2-diethylaminoethyl phosphorothioate;O,O-Diethyl S-2-diethylaminoethyl phosphorothiolate; R 5158;S-(Diethylaminoethyl) O,O-diethyl phosphorothioate; VG; VG (chemical warfareagent)
  • PSA 73.88000
  • LogP 3.24250

Amiton Chemical Properties

Empirical Formula: C10H24NO3PS
Molecular Weight: 269.3412 g/mol
Index of Refraction: 1.471
Density: 1.07 g/cm3
Flash Point: 144.3 °C
Enthalpy of Vaporization: 55.63 kJ/mol
Boiling Point: 315.1 °C at 760 mmHg
Vapour Pressure: 0.000448 mmHg at 25 °C 
Structure of Amiton (CAS NO.78-53-5):
                   
IUPAC Name of Amiton (CAS NO.78-53-5): 2-Diethoxyphosphorylsulfanyl-N,N-diethylethanamine

Amiton Uses

 Amiton (CAS NO.78-53-5) can be used as an acaricide and insecticide.

Amiton Toxicity Data With Reference

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
guinea pig LD50 subcutaneous 80ug/kg (0.08mg/kg)   Canadian Journal of Physiology and Pharmacology. Vol. 46, Pg. 109, 1968.
hamster LD50 subcutaneous 210ug/kg (0.21mg/kg)   Canadian Journal of Physiology and Pharmacology. Vol. 46, Pg. 109, 1968.
mouse LD50 intraperitoneal 300ug/kg (0.3mg/kg)   Journal of Agricultural and Food Chemistry. Vol. 12, Pg. 53, 1964.
mouse LD50 subcutaneous 190ug/kg (0.19mg/kg)   Canadian Journal of Physiology and Pharmacology. Vol. 46, Pg. 109, 1968.
rabbit LD50 subcutaneous 125ug/kg (0.125mg/kg)   Canadian Journal of Physiology and Pharmacology. Vol. 46, Pg. 109, 1968.
rat LD50 intraperitoneal 600ug/kg (0.6mg/kg)   Advances in Pest Control Research. Vol. 4, Pg. 117, 1961.
rat LD50 oral 3300ug/kg (3.3mg/kg)   Agricultural Research Service, USDA Information Memorandum. Vol. 20, Pg. 7, 1966.
rat LD50 subcutaneous 150ug/kg (0.15mg/kg)   Canadian Journal of Physiology and Pharmacology. Vol. 44, Pg. 745, 1966.
 

Amiton Consensus Reports

EPA Extremely Hazardous Substances List.

Amiton Safety Profile

A deadly poison by ingestion and subcutaneous routes. A cholinesterase inhibitor. An insecticide. See also PARATHION. When heated to decomposition it emits very toxic fumes of NOx, POx, and SOx.

Amiton Specification

 Amiton ,its cas register number is 78-53-5. It also can be called Tetram ; VG (O,O-Diethyl- S- [2- (diethylamino)ethyl] phosphorothioate) ; O,O-Diethyl S-(b-Diethylamino)ethyl Phosphorothiolate ; Thiophosphate de S-[2-(diéthylamino)éthyle] et de O,O-diéthyle ;and S-[2-(Diethylamino)ethyl]-O,O-diethylthiophosphat . It is highly toxic orally. Amiton (CAS NO.78-53-5) is a cholinesterase inhibitor, and is now considered too dangerous for use in agriculture but unlike other nerve agents it is classified under Schedule 2 of the Chemical Weapons Convention rather than the more restrictive Schedule 1. It was the trade name for the substance when it was marketed as an insecticide by ICI in the mid-1950s, and was described in a 1955 paper by Ghosh and another chemist, J. F. Newman, as being particularly effective against mites. It was brought to market as an insecticide by the company in 1954 but was subsequently withdrawn as too toxic.

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