Conditions | Yield |
---|---|
Oppenauer oxidation; | 85% |
With 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione In dimethyl sulfoxide for 1h; Ambient temperature; | 78% |
With sodium hydrogencarbonate; Dess-Martin periodane In dichloromethane; water at 25℃; for 2h; | 78% |
Conditions | Yield |
---|---|
Stage #1: Androstenedione With potassium tert-butylate In tert-butyl alcohol at 35 - 40℃; for 1.5h; Inert atmosphere; Stage #2: With acetic acid In water; tert-butyl alcohol at 20 - 25℃; Temperature; Reagent/catalyst; | 83% |
With potassium hydroxide; sodium hydrogencarbonate; acetic acid In 1,2-dimethoxyethane for 15h; Ambient temperature; | 75% |
With potassium tert-butylate; tert-butyl alcohol |
Conditions | Yield |
---|---|
With Celite; pyridinium chlorochromate In dichloromethane for 3.5h; Ambient temperature; Yields of byproduct given; | A n/a B 53% |
With chromic acid In acetone at 0℃; for 0.0666667h; Title compound not separated from byproducts; |
(8R,9S,10R,13S,14S)-6-bromo-10,13-dimethyl-7,8,9,10,11,12,13,14,15,16-decahydro-1H-cyclopenta[α]phenanthrene-3,17(2H,6H)-dione
5-androstenedione
Conditions | Yield |
---|---|
With zinc In ethanol; water at 20℃; for 72h; Inert atmosphere; | 52% |
dehydroepiandrosterone
A
androst-4,6-diene-3,17-dione
B
5-androstenedione
C
Androsta-1,4-diene-3,17-dione
Conditions | Yield |
---|---|
With 2,2'-bipyridylchromium peroxide In benzene for 3h; Product distribution; Heating; effect of various chromium(VI) based oxidants; | A 40% B 10% C 8% |
With 2,2'-bipyridylchromium peroxide In benzene for 3h; Heating; | A 40% B 10% C 8% |
5-androstenedione
Conditions | Yield |
---|---|
With bromine; acetic acid anschliessendes Behandeln mit CrO3 und Erwaermen des Reaktionsprodukts mit Zink-Pulver und Methanol; |
Conditions | Yield |
---|---|
With sodium acetate; acetic acid In methanol; water at 25℃; Rate constant; Mechanism; μ = 0.09; |
Conditions | Yield |
---|---|
With sodium hydroxide; 3-oxo-Δ5-steroid isomerase In methanol; water Rate constant; pH 5.0 to 5.1; | |
With acetic acid; sodium chloride In methanol at 6.5℃; pH=3.9 - 5.1; Kinetics; Further Variations:; Temperatures; | |
With phosphate buffer; D38E mutant of 3-oxo-Δ5 steroid isomerase In methanol at 15.3℃; pH=7.0; Kinetics; Further Variations:; Temperatures; |
Conditions | Yield |
---|---|
nachfolgendes Behandeln mit CrO3 und Erwaermen des Reaktionsprodukts mit Zink-Pulver und Methanol; |
Conditions | Yield |
---|---|
weitere Verbindung: Essigsaeure; Kochen des Reaktionsprodukts in Methanol mit Zink-Pulver; |
Androstenedione
A
6α-hydroxy-androst-4-ene-3,17-dione
B
5-androstenedione
E
androst-4-ene-3,6,17-trione
F
6β-hydroxy-4-androstene-3,17-dione
Conditions | Yield |
---|---|
Stage #1: Androstenedione With potassium tert-butylate In tert-butyl alcohol at 30 - 35℃; for 1h; Inert atmosphere; Stage #2: With acetic acid In water Stage #3: With D-glucose; glucose dehydrogenase (CDX-901)_; ketoreductase from Sphingomonas wittichii; NAD; NADP In aq. phosphate buffer; tert-butyl methyl ether at 45℃; for 65h; pH=6.5; Enzymatic reaction; | A 4 mg B n/a C n/a D n/a E 9 mg F 8 mg |
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: sodium methylate; potassium carbonate / ethanol / 1 h / 80 °C 2: aluminum isopropoxide / toluene; cyclohexanone / 3 h / 100 °C 3: potassium tert-butylate / tert-butyl alcohol / 6 h View Scheme |
5-androstenedione
ethylene glycol
3,3,17,17-diethylenedioxyandrost-5-ene
Conditions | Yield |
---|---|
With toluene-4-sulfonic acid In toluene for 12h; Heating / reflux; | 99% |
With toluene-4-sulfonic acid In toluene for 5h; | 92% |
toluene-4-sulfonic acid In toluene for 12h; Reflux; |
Conditions | Yield |
---|---|
With potassium hydroxide In methanol; water Ambient temperature; | 97% |
With sodium hydroxide In methanol; water at 25℃; | |
With sodium hydroxide; 3-oxo-Δ5-steroid isomerase In methanol; water Rate constant; pH 5.0 to 5.1; |
trifluoromethylsulfonic anhydride
5-androstenedione
androsten-3,5-dienyl-17-one 3-triflate
Conditions | Yield |
---|---|
With 2,6-di-tert-butyl-4-methylpyridine In dichloromethane for 2.5h; Ambient temperature; | 83% |
With 2,6-di-tert-butyl-4-methylpyridine In dichloromethane | 81% |
5-androstenedione
(8R,9S,10R,13S,14S)-4-diazo-10,13-dimethyl-7,8,9,10,11,12,13,14,15,16-decahydro-1H-cyclopenta[α]phenanthrene-3,17(2H,4H)-dione
Conditions | Yield |
---|---|
Stage #1: 5-androstenedione With 3-carbonxybenzenesulfonyl azide In acetonitrile at 20℃; for 0.333333h; Inert atmosphere; Stage #2: With 1,8-diazabicyclo[5.4.0]undec-7-ene In acetonitrile at 20℃; for 2h; Inert atmosphere; | 63% |
With 3-carbonxybenzenesulfonyl azide; 1,8-diazabicyclo[5.4.0]undec-7-ene In acetonitrile at 0℃; Inert atmosphere; | 62% |
5-androstenedione
5-hydro-3-oxaoctafluoropentanesulfonyl fluoride
Conditions | Yield |
---|---|
With 1,8-diazabicyclo[5.4.0]undec-7-ene In toluene | 50% |
Conditions | Yield |
---|---|
With acetic acid In toluene at 15 - 20℃; for 26h; | 25% |
5-androstenedione
A
dehydroepiandrosterone
B
3α-hydroxy-androst-5-en-17-one
Conditions | Yield |
---|---|
With ethanol; nickel Hydrogenation; |
Conditions | Yield |
---|---|
With fermenting yeast |
5-androstenedione
Conditions | Yield |
---|---|
With tetrapropylammonium perruthennate; 4 A molecular sieve; 4-methylmorpholine N-oxide In dichloromethane at 25℃; ultrasonic irradiation; Yield given; |
Conditions | Yield |
---|---|
With sodium hydroxide; acetic acetate In methanol; water at 25℃; Rate constant; Equilibrium constant; | |
With deuteriated sodium hydroxide; deuteroacetic acid In deuteromethanol; water-d2 at 12.8℃; pH=4.5 - 5.5; Kinetics; Further Variations:; Temperatures; |
5-androstenedione
(8R,9S,10R,13S,14S)-10,13-Dimethyl-17-oxo-2,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-ol anion
Conditions | Yield |
---|---|
With sodium hydroxide In methanol; water at 25℃; Rate constant; Equilibrium constant; Mechanism; μ=1.0 with KCl; |
5-androstenedione
6α-Chlor-androst-4-en-3,17-dion
Conditions | Yield |
---|---|
With pyridine; sulfuryl dichloride |
5-androstenedione
ethylene glycol
A
3,3,17,17-diethylenedioxyandrost-5-ene
B
3,17-bis-cycloethylenedioxy-androst-5-ene
C
3,3-ethylenedioxy-5-androsten-17-one
Conditions | Yield |
---|---|
With toluene-4-sulfonic acid In toluene Heating; |
5-androstenedione
hydrogen bromide
acetic acid
Androstenedione
Conditions | Yield |
---|---|
Hydrogenation; |
The CAS register number of Androst-5-ene-3,17-dione is 571-36-8. It also can be called as 5-Androsten-3,17-dione and the systematic name about this chemical is androst-5-ene-3,17-dione. The molecular formula about this chemical is C19H26O2 and the molecular weight is 286.4085. This chemical can be used in biochemistry.
Physical properties about Androst-5-ene-3,17-dione are: (1)ACD/LogP: 3.01; (2)ACD/LogD (pH 5.5): 3.01; (3)ACD/LogD (pH 7.4): 3.01; (4)ACD/BCF (pH 5.5): 113.59; (5)ACD/BCF (pH 7.4): 113.59; (6)ACD/KOC (pH 5.5): 1029.98; (7)ACD/KOC (pH 7.4): 1029.98; (8)#H bond acceptors: 2; (9)Polar Surface Area: 34.14Å2; (10)Index of Refraction: 1.551; (11)Molar Refractivity: 81.71 cm3; (12)Molar Volume: 255.8 cm3; (13)Polarizability: 32.39x10-24cm3; (14)Surface Tension: 42.6 dyne/cm; (15)Enthalpy of Vaporization: 67.81 kJ/mol; (16)Boiling Point: 423.7 °C at 760 mmHg; (17)Vapour Pressure: 2.19E-07 mmHg at 25°C.
You can still convert the following datas into molecular structure:
(1)SMILES: O=C4C/C3=C/C[C@@H]2[C@H](CC[C@@]1(C(=O)CC[C@H]12)C)[C@@]3(C)CC4
(2)InChI: InChI=1/C19H26O2/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(21)19(15,2)10-8-16(14)18/h3,14-16H,4-11H2,1-2H3/t14-,15-,16-,18-,19-/m0/s1
(3)InChIKey: SQGZFRITSMYKRH-QAGGRKNEBS
(4)Std. InChI: InChI=1S/C19H26O2/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(21)19(15,2)10-8-16(14)18/h3,14-16H,4-11H2,1-2H3/t14-,15-,16-,18-,19-/m0/s1
(5)Std. InChIKey: SQGZFRITSMYKRH-QAGGRKNESA-N
About|Contact|Cas|Product Name|Molecular|Country|Encyclopedia
Message|New Cas|MSDS|Service|Advertisement|CAS DataBase|Article Data|Manufacturers | Chemical Catalog
©2008 LookChem.com,License: ICP
NO.:Zhejiang16009103
complaints:service@lookchem.com Desktop View