-
Name
2-[(2E)-8-[5-(4,5-dihydroxy-4,6-dimethyl-oxan-2-yl)oxy-4-dimethylamino -6-methyl-oxan-2-yl]oxy-14-ethyl-10-hydroxy-15-[(5-hydroxy-3,4-dimetho xy-6-methyl-oxan-2-yl)oxymethyl]-1,5,9-trimethyl-4,12-dioxo-13,17-diox abicyclo[14.1.0]heptadec-2-en-7-yl]acetaldehyde
- EINECS
- CAS No. 1402-83-1
- Density 1.25g/cm3
- Solubility
- Melting Point 134.5°C
- Formula C46H77 N O17
- Boiling Point 959.5°Cat760mmHg
- Molecular Weight 916.24
- Flash Point 534.1°C
- Transport Information
- Appearance
- Safety Poison by several routes. When heated to decomposition it emits toxic fumes of NOx.
- Risk Codes
-
Molecular Structure
- Hazard Symbols
- Synonyms Angolamycin(8CI); Tylosin, 2A-deoxy-12,13-epoxy-12,13-dihydro- (9CI);4,17-Dioxabicyclo[14.1.0]heptadecane, tylosin deriv.
- PSA 230.97000
- LogP 2.07390
Angolamycin Chemical Properties
IUPAC Name: 2-[(14E)-9-[5-(4,5-dihydroxy-4,6-dimethyloxan-2-yl)oxy-4-(dimethylamino)-6-methyloxan-2-yl]oxy-3-ethyl-7-hydroxy-2-[(5-hydroxy-3,4-dimethoxy-6-methyloxan-2-yl)oxymethyl]-8,12,16-trimethyl-5,13-dioxo-4,17-dioxabicyclo[14.1.0]heptadec-14-en-10-yl]acetaldehyde
Synonyms of Angolamycin (CAS NO.1402-83-1): (14E)-2-{[(6-Deoxy-2,3-di-O-methylhexopyranosyl)oxy]methyl}-3-ethyl-7-hydroxy-8,12,16-trimethyl-5,13-dioxo-10-(2-oxoethyl)-4,17-dioxabicyclo[14.1.0]heptadec-14-en-9-yl 2,3,6-trideoxy-4-O-(2,6-dideoxy- 3-C-methylhexopyranosyl)-3-(dimethylamino)hexopyranoside
CAS NO: 1402-83-1
Molecular Formula: C46H77NO17
Molecular Weight : 916.100080 g/mol
Molecular Structure: .png)
H bond acceptors: 18
H bond donors: 4
Freely Rotating Bonds: 17
Polar Surface Area: 186.97 Å2
Index of Refraction: 1.547
Molar Refractivity: 232.33 cm3
Molar Volume: 732.4 cm3
Surface Tension: 53.6 dyne/cm
Density: 1.25 g/cm3
Flash Point: 534.1 °C
Enthalpy of Vaporization: 158.44 kJ/mol
Boiling Point: 959.5 °C at 760 mmHg
Vapour Pressure: 0 mmHg at 25°C
Angolamycin Toxicity Data With Reference
| Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
|---|---|---|---|---|---|
| mouse | LD50 | subcutaneous | 500mg/kg (500mg/kg) | "Index of Antibiotics from Actinomycetes," Umezawa, H. et al., eds., Tokyo, Univ. of Tokyo Press, 1967Vol. -, Pg. 135, 1967. | |
| mouse | LDLo | intraperitoneal | 280mg/kg (280mg/kg) | "Index of Antibiotics from Actinomycetes," Umezawa, H. et al., eds., Tokyo, Univ. of Tokyo Press, 1967Vol. -, Pg. 135, 1967. | |
| mouse | LDLo | unreported | 1gm/kg (1000mg/kg) | "Antibiotics: Origin, Nature, and Properties," Korzyoski, T., et al., eds., Washington, DC, American Soc. for Microbiology, 1978Vol. 1, Pg. 74, 1978. |
Angolamycin Safety Profile
Poison by several routes. When Angolamycin (CAS NO.1402-83-1) is heated to decomposition, it emits toxic fumes of NOx.
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