Anthramycin supplier | CasNO.4803-27-4

Name
Anthramycin
EINECS
CAS No. 4803-27-4
Article Data2
CAS DataBase
Density 1.5g/cm³
Solubility
Melting Point 188-194oC
Formula C₁₆H₁₇N₃O₄
Boiling Point 679.9°Cat760mmHg
Molecular Weight 315.4
Flash Point 365°C
Transport Information
Appearance
Safety Deadly poison by intraperitoneal route. Human mutation data reported. When heated to decomposition it emits toxic fumes of NO_x.
Risk Codes
Molecular Structure
Hazard Symbols
Synonyms 3-(9,11-dihydroxy-8-methyl-5-oxo-5,10,11,11a-tetrahydro-1H-benzo[e]pyrrolo[1,2-a][1,4]diazepine-2-yl)-acrylamide;(11R,11aS)-5,10,11,11a-tetrahydro-9,11-dihydroxy-8-methyl-5-oxo-1H-pyrrolo<2,1-c><1,4>benzodiazepin-2-trans-acrylamid;Antramycin;
PSA 115.89000
LogP 1.36060

Anthramycin Chemical Properties

IUPAC Name: (E)-3-(4,6-dihydroxy-3-methyl-11-oxo-5,6,6a,7-tetrahydropyrrolo[2,1-c][1,4]benzodiazepin-8-yl)prop-2-enamide
Molecular Weight: 315.32388 g/mol
Molecular Formula: C₁₆H₁₇N₃O₄
Density: 1.5 g/cm³
Boiling Point: 679.9 °C at 760 mmHg
Flash Point: 365 °C
Index of Refraction: 1.722
Molar Refractivity: 82.95 cm³
Molar Volume: 209.4 cm³
Polarizability: 32.88*10^-24cm³
Surface Tension: 85 dyne/cm
Enthalpy of Vaporization: 104.8 kJ/mol
Vapour Pressure: 2.05E-19 mmHg at 25°C
H-Bond Donor: 4
H-Bond Acceptor: 5
Rotatable Bond Count: 2
Tautomer Count: 14
Exact Mass: 315.121906
MonoIsotopic Mass: 315.121906
Topological Polar Surface Area: 116
Heavy Atom Count: 23
Complexity: 574
Canonical SMILES: CC1=C(C2=C(C=C1)C(=O)N3C=C(CC3C(N2)O)C=CC(=O)N)O
Isomeric SMILES: CC1=C(C2=C(C=C1)C(=O)N3C=C(CC3C(N2)O)/C=C/C(=O)N)O
InChI: InChI=1S/C16H17N3O4/c1-8-2-4-10-13(14(8)21)18-15(22)11-6-9(3-5-12(17)20)7-19(11)16(10)23/h2-5,7,11,15,18,21-22H,6H2,1H3,(H2,17,20)/b5-3+
InChIKey: VGQOVCHZGQWAOI-HWKANZROSA-N

Anthramycin Uses

Anthramycin (CAS NO.4803-27-4), an antitumour antibiotic produced by Streptomyces refuineus, belongs to the pyrrolo(1,4)benzodiazepine antibiotic group. Anthramycin (CAS NO.4803-27-4) within this group are potent inhibitors of nucleic acid synthesis because of their ability to form a labile covalent adduct with DNA.

Anthramycin Toxicity Data With Reference

1.	pic-esc 60 ng/plate	CNREA8 Cancer Research. 43 (1983),2819.
2.	dnd-mam:lym 400 µmol/L	BBACAQ Biochimica et Biophysica Acta. 475 (1977),521.
3.	mmo-eug 60 mg/L	NEOLA4 Neoplasma. 19 (1972),579.
4.	dns-hmn:fbr 200 µmol/L	JBCHA3 Journal of Biological Chemistry. 254 (1979),605.
5.	dnd-hmn:fbr 10 µmol/L	JBCHA3 Journal of Biological Chemistry. 254 (1979),605.
6.	ipr-mus LD50:650 µg/kg	TOLED5 Toxicology Letters. 18 (1983),337.

Anthramycin Consensus Reports

EPA Genetic Toxicology Program.

Anthramycin Safety Profile

Deadly poison by intraperitoneal route. Human mutation data reported. When heated to decomposition it emits toxic fumes of NO_x.

Anthramycin Specification

Anthramycin (CAS NO.4803-27-4) is also called (11R,11aS,βE)-5,10,11,11a-Tetrahydro-9,11-dihydroxy-8-methyl-5-oxo-1H-pyrrolo[2,1-c][1,4]benzodiazepin-2-acrylamide ; (11R,11aS,βE)-5,10,11,11a-Tetrahydro-9,11-dihydroxy-8-methyl-5-oxo-1H-pyrrolo[2,1-c][1,4]benzodiazepine-2-acrylamide .Anthramycin (CAS NO.4803-27-4) is high toxic. It is flammable. It will produce toxic nitrogen oxide fumes when buring. So the storage environment should be ventilate, low-temperature and dry. Keep Anthramycin (CAS NO.4803-27-4) separate from raw materials of food.

Product Name

Anthramycin