-
Name
Apamin
- EINECS 246-182-7
- CAS No. 24345-16-2
- Density 1.63
- Solubility
- Melting Point
- Formula C79H131 N31 O24 S4
- Boiling Point 847.17°C (rough estimate)
- Molecular Weight 2027.65
- Flash Point
- Transport Information
- Appearance
- Safety Poison by intravenous, parenteral, intracerebral, and intraperitoneal routes. When heated to decomposition it emits toxic fumes of SOx and NOx.
- Risk Codes
-
Molecular Structure
- Hazard Symbols
- Synonyms 66: PN: WO2008088422 FIGURE: 8 claimed protein;68: PN:WO2006116156 SEQID: 68 claimed protein;Apamin (reduced), cyclic (1?;15)-bis(disulfide);Apamine;L-Histidinamide,L-cysteinyl-L-asparaginyl-L-cysteinyl-L-lysyl-L-alanyl-L-prolyl-L-a-glutamyl-L-threonyl-L-alanyl-L-leucyl-L-cysteinyl-L-alanyl-L-arginyl-L-arginyl-L-cysteinyl-L-glutaminyl-L-glutaminyl-,cyclic (1?;15)-bis(disulfide);
- PSA 1021.52000
- LogP -0.31540
Apamin Chemical Properties
Molecular Formula: C79H131O24S4
Molecular Weight: 2027.65g/mol
EINECS: 246-182-7
Freely Rotating Bonds: 38
Polar Surface Area: 1021.52 Å2
Index of Refraction: 1.724
Molar Refractivity: 491.235 cm3
Molar Volume: 1238.918 cm3
Polarizability: 194.741× 10-24cm3
Surface Tension: 77.455 dyne/cm
Density: 1.636 g/cm3
The Cas Register Number of Apamin is 24345-16-2 .The chemical synonyms of Apamin (CAS No.24345-16-2) are H-+cys-asn-++cys-lys-ala-pro-glu-thr-ala-leu-+cys-ala-arg-arg-++cys-gln-gln- his-nh2 ; H-Cys-asn-cys-lys-ala-pro-glu-thr-ala-leu-cys-ala-arg-arg-cys-gln-gln-his-nh2 ; H-Cys-asn-cys-lys-ala-pro-glu-thr-ala-leu-cys-ala-arg-arg-cys-gln-gln-his-nh2 (disulfide bridge: 1-11, 3-15) ; Cys-asn-cys-lys-ala-pro-glu-thr-ala-leu-cys-ala-arg-arg-cys-gln-gln-his-nh2 ; Cys-asn-cys-lys-ala-pro-glu-thr-ala-leu-cys-ala-arg-cys-gln-gln-his-nh2 ; [Cys-asn-(cys-lys-ala-pro-glu-thr-ala-leu-cys]cycl-ala-arg-arg-cys)cycl-gln-gln-his-nh2 ; Cnckapetalcarrcqqh-nh2 ; Cnckapetalcarrcqqh-nh2 (disulfide bridge: 1-11,3-15) .Product categories of Apamin (CAS No.24345-16-2) are Peptide ; Beevoltage-gated ion channels ; Cell signaling and neuroscience ; Ion channel modulating peptides ; Monovalent ion channels ; Potassium channel modulators ; Potassium channel modulatorspeptides for cell biology ; Toxins and venoms ; Potassium channel .The molecular structure of Apamin (CAS No.24345-16-2) is
.
Apamin Uses
It can be used in organic synthesis.
Apamin Toxicity Data With Reference
| 1. | ipr-mus LD50:3800 µg/kg | TOXIA6 Toxicon. 22 (1984),308. | ||
| 2. | ivn-mus LD50:4 mg/kg | NSAPCC Naunyn-Schmiedeberg’s Archives of Pharmacology. 300 (1977),189. | ||
| 3. | ice-mus LD50:1800 ng/kg | TOXIA6 Toxicon. 22 (1984),308. | ||
| 4. | par-mus LD50:600 mg/kg | TOXIA6 Toxicon. 20 (1982),157. |
Apamin Safety Profile
Poison by intravenous, parenteral, intracerebral, and intraperitoneal routes. When heated to decomposition it emits toxic fumes of SOx and NOx.
Safety Statements: 22-24/25
S22: Do not breathe dust.
S24/25: Avoid contact with skin and eyes.
RIDADR: 2811
WGK Germany: 3
RTECS: CD6899900
F: 3-10
HazardClass: 6.1(b)
PackingGroup: III
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