Product Name

  • Name

    QUINACRINE DIHYDROCHLORIDE DIHYDRATE

  • EINECS 201-508-7
  • CAS No. 83-89-6
  • Article Data21
  • CAS DataBase
  • Density 1.156 g/cm3
  • Solubility
  • Melting Point 247-250 °C
  • Formula C23H30 Cl N3 O
  • Boiling Point 557.1 °C at 760 mmHg
  • Molecular Weight 399.964
  • Flash Point 290.7 °C
  • Transport Information
  • Appearance
  • Safety Poison by intravenous and subcutaneous routes. Moderately toxic by ingestion. Mutation data reported. Experimental reproductive effects. Has been implicated in aplastic anemia. When heated to decomposition, it emits very toxic fumes of Cl− and NOx.
  • Risk Codes 36/37/38-22
  • Molecular Structure Molecular Structure of 83-89-6 (QUINACRINE DIHYDROCHLORIDE DIHYDRATE)
  • Hazard Symbols
  • Synonyms Acridine,6-chloro-9-[[4-(diethylamino)-1-methylbutyl]amino]-2-methoxy- (8CI); (?à)-Quinacrine;6-Chloro-9-[[4-(diethylamino)-1-methylbutyl]amino]-2-methoxyacridine; Acrichin;Acrinamine; Acriquine; Akrichin; Antimalarina; Atabrine; Haffkinine; Italchine;Mepacrine; Quinacrine; ST 439
  • PSA 37.39000
  • LogP 6.04540

Atabrine Chemical Properties

IUPAC Name: 4-N-(6-Chloro-2-methoxyacridin-9-yl)-1-N,1-N-diethylpentane-1,4-diamine
Synonyms: 1,4-Pentanediamine, N~4~-(6-chloro-2-methoxy-9-acridinyl)-N~1~,N~1~-diethyl- ; 1,4-Pentanediamine, N~4~-[(9E)-6-chloro-2-methoxy-9(10H)-acridinylidene]-N~1~,N~1~-diethyl- ; 1,4-Pentanediamine, N4-(6-chloro-2-methoxy-9-acridinyl)-N1,N1-diethyl- ; 1,4-Pentanediamine, N4-(6-chloro-2-methoxy-9-acridinyl)-N1,N1-diethyl-, (+-)-  ; 3-Chloro-7-methoxy-9-(1-methyl-4-diethyl Aminobutylamino)acridine ; 6-Chloro-9-[[4-(diethylamino)-1-methylbutyl]amino]-2-methoxyacridine ; Acridine, 6-chloro-9-((4-(diethylamino)-1-methylbutyl)amino)-2-methoxy- ; Antimony sodium tartrate ; DL-6-Chloro-9-((4-(diethylamino)-1-methylbutyl)amino)-2-methoxy-acridine ; N~4~-(6-Chloro-2-methoxy-9-acridinyl)-N~1~,N~1~-diethyl-1,4-pentanediamine
CAS NO: 83-89-6
Molecular Formula of Atabrine (CAS NO.83-89-6) : C23H30ClN3O
Molecular Weight of Atabrine (CAS NO.83-89-6) : 399.9568
Molecular Structure of Atabrine (CAS NO.83-89-6) :
EINECS: 201-508-7
Mol File: 83-89-6.mol
Index of Refraction: 1.622
Surface Tension: 46.1 dyne/cm
Density: 1.156 g/cm3
Flash Point: 290.7 °C
Enthalpy of Vaporization: 83.88 kJ/mol
Boiling Point: 557.1 °C at 760 mmHg
Vapour Pressure: 1.9E-12 mmHg at 25°C
Melting point: 247-250 °C

Atabrine Toxicity Data With Reference

1.    

mma-sat 500 µg/plate

     TXAPA9    Toxicology and Applied Pharmacology. 52 (1980),237.
2.    

mmo-omi 50 mg/L

     GENTAE    Genetics. 90 (1978),1.
3.    

mmo-sat 200 mg/L

     JOBAAY    Journal of Bacteriology. 122 (1975),549.
4.    

mnt-mus-ipr 280 µmol/kg

     MUREAV    Mutation Research. 26 (1974),553.
5.    

dns-mam:lym 1 µmol/L

     CBINA8    Chemico-Biological Interactions. 8 (1974),113.
6.    

orl-mus LD50:1320 mg/kg

     FAZMAE    Fortschritte der Arzneimittelforschung. 17 (1973),108.
7.    

scu-mus LD50:239 mg/kg

     JPETAB    Journal of Pharmacology and Experimental Therapeutics. 119 (1957),444.
8.    

ivn-mus LD50:50 mg/kg

     THERAP    Therapie. 25 (1970),823.
9.    

orl-ckn LD50:714 mg/kg

     AEPPAE    Naunyn-Schmiedeberg’s Archiv fuer Experimentelle Pathologie und Pharmakologie. 201 (1943),402.

Atabrine Safety Profile

Poison by intravenous and subcutaneous routes. Moderately toxic by ingestion. Mutation data reported. Experimental reproductive effects. Has been implicated in aplastic anemia. When heated to decomposition, it emits very toxic fumes of Cl− and NOx.
Hazard CodesHarmfulXn
Risk Statements 36/37/38-22 
R36/37/38:Irritating to eyes, respiratory system and skin. 
R22:Harmful if swallowed.
Safety Statements 37/39-26
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S37/39:Wear suitable gloves and eye/face protection.

Atabrine Specification

General Information: As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear.
Extinguishing Media: Use water spray, dry chemical, carbon dioxide, or chemical foam. 
Handling: Avoid breathing dust, vapor, mist, or gas. Avoid contact with skin and eyes. Avoid ingestion and inhalation.
Storage: Store in a cool, dry place. Store in a tightly closed container.

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