• Name

  Atracurium besylate

• EINECS 264-743-4
• CAS No. 64228-81-5
• Article Data4
• CAS DataBase
• Density
• Solubility H₂O: ~27 mg/mL
• Melting Point 85-90 °C
• Formula C₅₃H₇₂N₂O₁₂^.2(C₆H₅O₃S)
• Boiling Point
• Molecular Weight 1243.5
• Flash Point
• Transport Information
• Appearance White to yellowish-white powder
• Safety 24/25
• Risk Codes
• Molecular Structure
• Hazard Symbols
• Synonyms Tracrium;Atracurii besilas [INN-Latin];Atracurium Besilate injection;Besilate datracurium [INN-French];Isoquinolinium, 2,2-(1,5-pentanediylbis(oxy(3-oxo-3,1-propanediyl)))bis(1-((3,4-dimethoxyphenyl)methyl)-1,2,3,4-tetrahydro-6,7-dimethoxy-2-methyl-, dibenzenesulfonate;Atracurium besilate;Track detectorsTracrium;BW 33A;Tracrium (TN);Besilato de atracurio [INN-Spanish];Atracurium besylate (USP);Atracurii besilas;Atracurium besy;
• PSA 257.60000
• LogP 11.32610

Synthetic route

64228-78-0, 64493-10-3, 83285-74-9, 96687-52-4, 96687-53-5, 110817-20-4

pentamethylene bis(1-(3,4-dimethoxybenzyl)-3,4-dihydro-6,7-dimethoxy-1H-isoquinoline-2-propionate) dioxalate

80-18-2

Methyl benzenesulfonate

64228-81-5

atracurium besylate

Conditions

Conditions	Yield
In acetonitrile for 48h; Ambient temperature;	85%

93-40-3

(3,4-Dimethoxyphenyl)acetic acid

64228-81-5

atracurium besylate

Conditions

Conditions	Yield
Multi-step reaction with 5 steps 1: 92 percent / 2 h / 190 - 210 °C 2: phosphoryl chloride / toluene / 3 h / Heating 3: 71 percent / sodium borohydride / 19 h / Ambient temperature 4: 51 percent / benzene / 48 h / Heating 5: 85 percent / acetonitrile / 48 h / Ambient temperature View Scheme

139-76-4

N-(3,4-dimethoxyphenethyl)-2-(3,4-dimethoxyphenyl)acetamide

64228-81-5

atracurium besylate

Conditions

Conditions	Yield
Multi-step reaction with 4 steps 1: phosphoryl chloride / toluene / 3 h / Heating 2: 71 percent / sodium borohydride / 19 h / Ambient temperature 3: 51 percent / benzene / 48 h / Heating 4: 85 percent / acetonitrile / 48 h / Ambient temperature View Scheme

6957-27-3

3,4-dihydropapaverine

64228-81-5

atracurium besylate

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1: 71 percent / sodium borohydride / 19 h / Ambient temperature 2: 51 percent / benzene / 48 h / Heating 3: 85 percent / acetonitrile / 48 h / Ambient temperature View Scheme

6429-04-5

1,2,3,4-tetrahydro-1-(3,4-dimethoxybenzyl)-6,7-dimethoxyisoquinoline hydrochloride

64228-81-5

atracurium besylate

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: 51 percent / benzene / 48 h / Heating 2: 85 percent / acetonitrile / 48 h / Ambient temperature View Scheme

120-20-7

2-(3,4-dimethoxyphenyl)-ethylamine

palladium/barium sulfate

palladium/barium sulfate

64228-81-5

atracurium besylate

Conditions

Conditions	Yield
Multi-step reaction with 5 steps 1: 92 percent / 2 h / 190 - 210 °C 2: phosphoryl chloride / toluene / 3 h / Heating 3: 71 percent / sodium borohydride / 19 h / Ambient temperature 4: 51 percent / benzene / 48 h / Heating 5: 85 percent / acetonitrile / 48 h / Ambient temperature View Scheme

64228-81-5

atracurium besylate

A

cisatracurium besilate

B

(1R-trans,1'R-trans)-2,2'-[1,5-pentanediylbis[oxy(3-oxo-3,1-propanediyl)]]bis[1-(3,4-dimethoxyphenyl)methyl]-1,2,3,4-tetrahydro-6,7-dimethoxy-2-methylisoquinolinium dibenzenesulfonate

C

(1R-cis,1'R-trans)-2,2'-[1,5-pentanediylbis[oxy(3-oxo-3,1-propanediyl)]]-bis[1-[(3,4-dimethoxyphenyl)methyl]-1,2,3,4-tetrahydro-6,7-dimethoxy-2-methyl]-isoquinolinium dibenzenesulfonate

Conditions

Conditions	Yield
Purification / work up; Resolution of racemate;

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Atracurium besylate Chemical Properties

Atracurium besylate Uses

Atracurium besylate Safety Profile

Atracurium besylate Specification