-
Name
Auranofin
- EINECS 251-801-9
- CAS No. 34031-32-8
- Density g/cm3
- Solubility
- Melting Point 103 - 105ºC
- Formula C20H34 Au O9 P S
- Boiling Point 425.5°Cat760mmHg
- Molecular Weight 678.54
- Flash Point 298°C
- Transport Information
- Appearance Needles.
- Safety Poison by ingestion, intraperitoneal, and intravenous routes. Human systemic effects by ingestion: ulceration or bleeding from stomach. An experimental teratogen. Other experimental reproductive effects. Human mutation data reported. When heated to decomposition it emits very toxic fumes of SOx and POx. See also GOLD COMPOUNDS.
- Risk Codes 63-22
-
Molecular Structure
- Hazard Symbols Xn
- Synonyms Gold,(1-thio-b-D-glucopyranosato)(triethylphosphine)-,2,3,4,6-tetraacetate (8CI); Gold, (1-thio-b-D-glucopyranose2,3,4,6-tetraacetato-S)(triethylphosphine)-; b-D-Glucopyranose, 1-thio-, 2,3,4,6-tetraacetate, goldcomplex; Aktil; Auranofin; Crisinor; Crisofin; NSC 321521; Ridaura; Ridauran;SKF 39162; SKF 39162D; [(Tetra-O-acetyl-b-D-glucopyranosyl)thio](triethylphosphine)gold
- PSA 149.54000
- LogP 2.79250
Auranofin Chemical Properties
IUPAC: Gold(1+); 3,4,5-triacetyloxy-6-(acetyloxymethyl)oxane-2-thiolate;triethylphosphane
Auranofin with CAS NO. of 34031-32-8 is also called for (1-Thio-beta-D-glucopyranosato)(triethylphosphine)gold 2,3,4,6-tetraacetate ; 2,3,4,6-Tetra-O-acetyl-1-thio-beta-D-glucopyranosato-S (triethylphosphine)gold ; Auranofina ; Auranofinum ; EINECS 251-801-9 ; HSDB 7172 ; Ridaura ; SK&F 39162D ; SK&F D-39162 ; SKF-39162d ; Triethylphosphine gold ; UNII-3H04W2810V ; Gold, (1-thio-beta-D-glucopyranosato-S)(triethylphosphine)-, 2,3,4,6-tetraacetate ; Gold, (1-thio-beta-D-glucopyranose 2,3,4,6-tetraacetato-S)(triethylphosphine)- (9CI) ; Gold, (2,3,4,6-tetra-O-acetyl-1-thio-beta-D-glucopyranosato-S)(triethylphosphine)- and so on.
Molecular Formula: C20H34AuO9PS
Molecular Weight: 678.48
EINECS: 251-801-9
ACD/LogP: 1.95
ACD/LogD (pH 5.5): 1.93
ACD/LogD (pH 7.4): 1.16
ACD/BCF (pH 5.5): 16.87
ACD/BCF (pH 7.4): 2.91
ACD/KOC (pH 5.5): 258.3
ACD/KOC (pH 7.4): 44.52
H bond acceptors: 9
H bond donors: 0
Freely Rotating Bonds: 10
Heavy Atom Count: 32
Formal Charge: 0
Complexity: 532
Isotope Atom Count: 0
Defined Atom StereoCenter Count: 0
Undefined Atom StereoCenter Count: 5
Defined Bond StereoCenter Count: 0
Undefined Bond StereoCenter Count: 0
Covalently-Bonded Unit Count: 3
Flash Point: 298°C
Melting Point: 103-105°C
Enthalpy of Vaporization: 68.02 kJ/mol
Boiling Point: 425.5°C at 760 mmHg
Vapour Pressure: 1.9E-07 mmHg at 25°C
The appearance of Auranofin (CAS NO.34031-32-8) is needle.
The molecular structure of Auranofin with CAS NO. of 34031-32-8 :
Auranofin Uses
Auranofin with CAS NO. of 34031-32-8 is used in the treatment of rheumatoid arthritis.
Auranofin Toxicity Data With Reference
| Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
|---|---|---|---|---|---|
| dog | LD50 | intravenous | 3200ug/kg (3.2mg/kg) | Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 17, Pg. 1106, 1986. | |
| man | TDLo | oral | 1200ug/kg/2W- (1.2mg/kg) | GASTROINTESTINAL: ULCERATION OR BLEEDING FROM STOMACH | Journal of Rheumatology. Vol. 13, Pg. 228, 1986. |
| mouse | LD50 | intraperitoneal | 33800ug/kg (33.8mg/kg) | Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 17, Pg. 1106, 1986. | |
| mouse | LD50 | intravenous | 22600ug/kg (22.6mg/kg) | Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 17, Pg. 1106, 1986. | |
| mouse | LD50 | oral | 84940ug/kg (84.94mg/kg) | Bollettino Chimico Farmaceutico. Vol. 128, Pg. 22, 1989. | |
| mouse | LD50 | subcutaneous | 53600ug/kg (53.6mg/kg) | Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 17, Pg. 1106, 1986. | |
| rat | LD50 | intraperitoneal | 25500ug/kg (25.5mg/kg) | Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 17, Pg. 1106, 1986. | |
| rat | LD50 | intravenous | 39mg/kg (39mg/kg) | Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 17, Pg. 1106, 1986. | |
| rat | LD50 | oral | 265mg/kg (265mg/kg) | Veterinary Pathology. Vol. 15(Suppl, | |
| rat | LD50 | subcutaneous | 235mg/kg (235mg/kg) | Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 17, Pg. 1106, 1986. | |
| women | TDLo | oral | 5400ug/kg/10D (5.4mg/kg) | BEHAVIORAL: TOXIC PSYCHOSIS BEHAVIORAL: MUSCLE WEAKNESS BEHAVIORAL: MUSCLE CONTRACTION OR SPASTICITY) | Arthritis and Rheumatism. Vol. 27, Pg. 1316, 1984. |
Auranofin Safety Profile
Poison by ingestion, intraperitoneal, and intravenous routes. Human systemic effects by ingestion: ulceration or bleeding from stomach. An experimental teratogen. Other experimental reproductive effects. Human mutation data reported. When heated to decomposition it emits very toxic fumes of SOx and POx. See also GOLD COMPOUNDS.
Auranofin Specification
The exact mechanism of Auranofin (CAS NO.34031-32-8) action is unknown, but it is believed to act via immunological mechanisms and alteration of lysosomal enzyme activity. Its efficacy is slightly less than that of injected gold salts, but it is better tolerated, and side effects which occur are potentially less serious.
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