-
Name
(5alpha,6beta)-6-azido-4,5-epoxy-17-methylmorphinan-3-ol
- EINECS 245-349-1
- CAS No. 22952-87-0
- Article Data4
- CAS DataBase
- Density g/cm3
- Solubility
- Melting Point
- Formula C17H20 N4 O2
- Boiling Point °Cat760mmHg
- Molecular Weight 312.371
- Flash Point °C
- Transport Information
- Appearance
- Safety Poison by ingestion, subcutaneous, and intravenous routes. When heated to decomposition it emits toxic fumes of NOx. See also AZIDES and MORPHINE HYDROCHLORIDE; MORPHINE METHOCHLORIDE; MORPHINE MONOHYDRATE; MORPHINE SULFATE.
- Risk Codes
-
Molecular Structure
- Hazard Symbols
- Synonyms Morphinan-3-ol,6b-azido-4,5a-epoxy-17-methyl- (8CI);Azidomorphine;
- PSA
- LogP
Azidomorphine Chemical Properties
Molecular Formula: C17H20N4O2
Molar mass: 312.3663 g/mol
EINECS: 245-349-1
Product categories of Azidomorphine (22952-87-0):Toxicant
Structure of Azidomorphine (22952-87-0):
XLogP3-AA: 3.4
H-Bond Donor: 1
H-Bond Acceptor: 5
SMILES: [N-]=[N+]=N\[C@H]4[C@@H]5Oc1c2c(ccc1O)C[C@H]3N(CC[C@]25[C@H]3CC4)C
InChI: InChI=1/C17H20N4O2/c1-21-7-6-17-10-3-4-11(19-20-18)16(17)23-15-13(22)5-2-9(14(15)17)8-12(10)21/h2,5,10-12,16,22H,3-4,6-8H2,1H3/t10-,11+,12+,16-,17-/m0/s1
InChIKey: KZOKOEQTKWBKOK-XHQKLZHNBX
Std. InChI: InChI=1S/C17H20N4O2/c1-21-7-6-17-10-3-4-11(19-20-18)16(17)23-15-13(22)5-2-9(14(15)17)8-12(10)21/h2,5,10-12,16,22H,3-4,6-8H2,1H3/t10-,11+,12+,16-,17-/m0/s1
Std. InChIKey: KZOKOEQTKWBKOK-XHQKLZHNSA-N
Azidomorphine Toxicity Data With Reference
| Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
|---|---|---|---|---|---|
| mouse | LD50 | intravenous | 13mg/kg (13mg/kg) | Journal of Pharmacy and Pharmacology. Vol. 27, Pg. 99, 1975. | |
| mouse | LD50 | oral | 58mg/kg (58mg/kg) | Journal of Pharmacy and Pharmacology. Vol. 27, Pg. 99, 1975. | |
| mouse | LD50 | subcutaneous | 16mg/kg (16mg/kg) | Journal of Pharmacy and Pharmacology. Vol. 27, Pg. 99, 1975. | |
| rat | LD50 | intravenous | 8100ug/kg (8.1mg/kg) | Journal of Pharmacy and Pharmacology. Vol. 25, Pg. 929, 1973. | |
| rat | LD50 | oral | 62mg/kg (62mg/kg) | Journal of Pharmacy and Pharmacology. Vol. 25, Pg. 929, 1973. | |
| rat | LD50 | subcutaneous | 13mg/kg (13mg/kg) | Journal of Pharmacy and Pharmacology. Vol. 25, Pg. 929, 1973. | |
| rat | LD50 | unreported | 13mg/kg (13mg/kg) | BEHAVIORAL: ANALGESIA | Pharmacological Research Communications. Vol. 5, Pg. 175, 1973. |
Azidomorphine Safety Profile
Poison by ingestion, subcutaneous, and intravenous routes. When heated to decomposition it emits toxic fumes of NOx. See also AZIDES and MORPHINE HYDROCHLORIDE; MORPHINE METHOCHLORIDE; MORPHINE MONOHYDRATE; MORPHINE SULFATE.
Azidomorphine Specification
Azidomorphine (22952-87-0) is an opiate analogue that is a derivative of morphine, and also can be called -Deoxy-6-azidodihydroisomorphine ; Morphinan-3-ol, 6.beta.-azido-4,5.alpha.-epoxy-17-methyl- ;and Morphinan-3-ol, 6-azido-4,5-epoxy-17-methyl-, (5.alpha.,6.beta.)- . It has similar effects to other opioid agonists including analgesia, sedation and respiratory depression. However its addiction liability has been found to be slightly lower than that of morphine in animal studies.
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