Product Name

  • Name

    Basic Red 1

  • EINECS 213-584-9
  • CAS No. 989-38-8
  • Density 1.15g/cm3
  • Solubility Insoluble in water
  • Melting Point 290 °C
  • Formula C28H31N2O3.Cl
  • Boiling Point <200ºC
  • Molecular Weight 479.019
  • Flash Point 318.6ºC
  • Transport Information
  • Appearance dark reddish purple, brown or black crystalline solid
  • Safety 36/37/39-26
  • Risk Codes 22
  • Molecular Structure Molecular Structure of 989-38-8 (Basic Red 1)
  • Hazard Symbols HarmfulXn
  • Synonyms Benzoicacid, o-[6-(ethylamino)-3-(ethylimino)-2,7-dimethyl-3H-xanthen-9-yl]-, ethylester, monohydrochloride (8CI);Rhodamine 6GCP (6CI);Xanthylium,9-[2-(ethoxycarbonyl)phenyl]-3,6-bis(ethylamino)-2,7-dimethyl-, chloride (9CI);Aizen Rhodamine 6GCP;Basonyl Red 482;Basonyl Red 483;C.I.45160;C.I. Basic Red 1;Calcozine Red 6G;Calcozine Rhodamine 6GX;Eljon PinkToner;Exciton 590;Fanal Pink B;Fanal Pink GFK;Fanal Red 25532;Flexo Red482;Heliostable Brilliant Pink B extra;Mitsui Rhodamine 6GCP;NSC 36345;NycoLiquid Red GF;R 634;R 6G;Rh 6G;Rhodamin 6G;Rhodamine 4GD;Rhodamine 4GH;Rhodamine 590 Chloride;Rhodamine 5GDN;Rhodamine 5GDN Extra;Rhodamine 5GL;Rhodamine 6G;Rhodamine 6G Extra;Rhodamine 6Gchloride;Rhodamine 6GBN;Rhodamine 6GDN;Rhodamine 6GDN Extra;Rhodamine 6GH;Rhodamine 6GO;Rhodamine 6GX;Rhodamine 6JH;Rhodamine 6JH-SA;Rhodamine 6JH-SA Extra 1150;Rhodamine 6Zh-DN;Rhodamine F 5GL;Rhodamine GDN;Rhodamine GDNExtra;Rhodamine Y 20-7425;Rhodamine Zh;Silosuper Pink B;Vali Fast Red 1308;
  • PSA 63.83000
  • LogP 7.22550

Synthetic route

N,N'-diethyl-2,7-dimethyl-rhodamine hydrochloride

N,N'-diethyl-2,7-dimethyl-rhodamine hydrochloride

rhodamine 6G
989-38-8

rhodamine 6G

Conditions
ConditionsYield
With ethanol; sulfuric acid
C20H12O5*C16H11N

C20H12O5*C16H11N

rhodamine 6G
989-38-8

rhodamine 6G

C20H12O5*C16H11N*C28H30N2O3

C20H12O5*C16H11N*C28H30N2O3

Conditions
ConditionsYield
In dichloromethane for 48h; pH=7.4;89%
rhodamine 6G
989-38-8

rhodamine 6G

ethylenediamine
107-15-3

ethylenediamine

N-(rhodamine-6G)lactam-ethylenediamine
440666-99-9

N-(rhodamine-6G)lactam-ethylenediamine

Conditions
ConditionsYield
With ammonium hydroxide In N,N-dimethyl-formamide at 20℃; for 24h;88%
In methanol for 3h; Reflux;78.4%
In ethanol at 70℃; for 12h;75%
rhodamine 6G
989-38-8

rhodamine 6G

rhodamine 19
41382-37-0

rhodamine 19

Conditions
ConditionsYield
at 265 - 275℃; for 5h; vacuum;86%
rhodamine 6G
989-38-8

rhodamine 6G

1,5-diamino-3-azapentane
111-40-0

1,5-diamino-3-azapentane

C30H37N5O2

C30H37N5O2

Conditions
ConditionsYield
In ethanol at 90℃; Inert atmosphere;83%
In ethanol Reflux;
rhodamine 6G
989-38-8

rhodamine 6G

rhodamine hydrazide
932013-08-6

rhodamine hydrazide

Conditions
ConditionsYield
With hydrazine hydrate In ethanol Reflux;79%
Stage #1: rhodamine 6G With hydrazine hydrate In ethanol for 12h; Reflux;
Stage #2: With sodium hydroxide In dichloromethane; water		74%
With hydrazine hydrate In ethanol Reflux; Sonication;73%
rhodamine 6G
989-38-8

rhodamine 6G

3',6'-bis(ethylamino)-2',7'-dimethyl-2,3-dihydrospiro[isoindole-1,9'-xanthene]-3-one

3',6'-bis(ethylamino)-2',7'-dimethyl-2,3-dihydrospiro[isoindole-1,9'-xanthene]-3-one

Conditions
ConditionsYield
With ammonium hydroxide In N,N-dimethyl-formamide at 20℃; for 24h;79%
rhodamine 6G
989-38-8

rhodamine 6G

C26H30N4O2

C26H30N4O2

Conditions
ConditionsYield
With hydrazine hydrate In ethanol for 2h; Reflux;78%
2,2',2''-triaminotriethylamine
4097-89-6

2,2',2''-triaminotriethylamine

rhodamine 6G
989-38-8

rhodamine 6G

C32H42N6O2

C32H42N6O2

Conditions
ConditionsYield
With ammonium hydroxide In N,N-dimethyl-formamide at 20℃; for 24h;76%
rhodamine 6G
989-38-8

rhodamine 6G

benzylamine
100-46-9

benzylamine

C33H33N3O2

C33H33N3O2

Conditions
ConditionsYield
In ethanol for 10h; Reflux;75%
potassium trifluoromethansulfonate
2926-27-4

potassium trifluoromethansulfonate

rhodamine 6G
989-38-8

rhodamine 6G

C28H31N2O3(1+)*CF3O3S(1-)

C28H31N2O3(1+)*CF3O3S(1-)

Conditions
ConditionsYield
In chloroform; water at 20℃; for 7h;72%
propylamine
107-10-8

propylamine

rhodamine 6G
989-38-8

rhodamine 6G

rhodamine 6G ethylamine
1422430-50-9

rhodamine 6G ethylamine

Conditions
ConditionsYield
In ethanol for 12h; Reflux;70%
C55H51NO12

C55H51NO12

rhodamine 6G
989-38-8

rhodamine 6G

C66H65N3O12

C66H65N3O12

Conditions
ConditionsYield
With piperidine In N,N-dimethyl-formamide at 90℃; for 0.5h; Microwave irradiation; Inert atmosphere;68%
rhodamine 6G
989-38-8

rhodamine 6G

1-aminooctadecane
124-30-1

1-aminooctadecane

C44H63N3O2
1422430-49-6

C44H63N3O2

Conditions
ConditionsYield
In ethanol for 24h; Reflux;67%
rhodamine 6G
989-38-8

rhodamine 6G

2-(4-(ethylamino)-2-hydroxy-5-methylbenzoyl)benzoic acid

2-(4-(ethylamino)-2-hydroxy-5-methylbenzoyl)benzoic acid

Conditions
ConditionsYield
With sodium hydroxide at 165℃; for 57h;65%
piperazine
110-85-0

piperazine

rhodamine 6G
989-38-8

rhodamine 6G

C30H37N5O2

C30H37N5O2

Conditions
ConditionsYield
With ammonium hydroxide In N,N-dimethyl-formamide at 20℃; for 24h;60%
rhodamine 6G
989-38-8

rhodamine 6G

rhodamine 19 hydrochloride salt

rhodamine 19 hydrochloride salt

Conditions
ConditionsYield
With lithium hydroxide In tetrahydrofuran for 4h; Heating;
rhodamine 6G
989-38-8

rhodamine 6G

N-acetyl-rhodamine

N-acetyl-rhodamine

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 86 percent / 5 h / 265 - 275 °C / vacuum
2: 21 percent / Et3N; DMAP / CH2Cl2 / Heating
View Scheme
rhodamine 6G
989-38-8

rhodamine 6G

N-acetyl-N'-benzyloxycarbonyl-rhodamine

N-acetyl-N'-benzyloxycarbonyl-rhodamine

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: 86 percent / 5 h / 265 - 275 °C / vacuum
2: 21 percent / Et3N; DMAP / CH2Cl2 / Heating
3: 85 percent / NaH / tetrahydrofuran / 3 h / Heating
View Scheme
rhodamine 6G
989-38-8

rhodamine 6G

rhodamine 19 hydroxycarbonylmethyl ester bromide

rhodamine 19 hydroxycarbonylmethyl ester bromide

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: 86 percent / 5 h / 265 - 275 °C / vacuum
2: 77 percent / NaI; i-Pr2NEt / acetonitrile / 2.5 h / Heating
3: 79 percent / H2 / Pd/C / ethanol / 24 h / 20 °C
View Scheme
rhodamine 6G
989-38-8

rhodamine 6G

rhodamine 19 ethoxycarbonylmethyl ester bromide

rhodamine 19 ethoxycarbonylmethyl ester bromide

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: LiOH*H2O / tetrahydrofuran / 4 h / Heating
2: 221 mg / NaI; i-Pr2NEt / acetonitrile / 20 h / Heating
View Scheme
Multi-step reaction with 2 steps
1: 86 percent / 5 h / 265 - 275 °C / vacuum
2: 80 percent / NaI; i-Pr2NEt / acetonitrile / 24 h / Heating
View Scheme
rhodamine 6G
989-38-8

rhodamine 6G

rhodamine 19 benzyl ester bromide

rhodamine 19 benzyl ester bromide

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 86 percent / 5 h / 265 - 275 °C / vacuum
2: 66 percent / NaI; i-Pr2NEt / acetonitrile / 4 h / Heating
View Scheme
rhodamine 6G
989-38-8

rhodamine 6G

rhodamine 19 4-chloromethyl-1-phenylmethyl ester chloride

rhodamine 19 4-chloromethyl-1-phenylmethyl ester chloride

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 86 percent / 5 h / 265 - 275 °C / vacuum
2: 88 percent / NaI; i-Pr2NEt / acetonitrile / 2.5 h / Heating
View Scheme
rhodamine 6G
989-38-8

rhodamine 6G

rhodamine 19 benzyloxycarbonylmethyl ester bromide

rhodamine 19 benzyloxycarbonylmethyl ester bromide

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 86 percent / 5 h / 265 - 275 °C / vacuum
2: 77 percent / NaI; i-Pr2NEt / acetonitrile / 2.5 h / Heating
View Scheme
rhodamine 6G
989-38-8

rhodamine 6G

rhodamine 19 4-(2'-methyl-propionyl)-oxymethyl-1-phenylmethyl ester iodide

rhodamine 19 4-(2'-methyl-propionyl)-oxymethyl-1-phenylmethyl ester iodide

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: 86 percent / 5 h / 265 - 275 °C / vacuum
2.1: 88 percent / NaI; i-Pr2NEt / acetonitrile / 2.5 h / Heating
3.1: Cs2CO3 / dimethylformamide / 1 h / 20 °C
3.2: 79 percent / NaI / dimethylformamide / 24 h / 20 °C
View Scheme
rhodamine 6G
989-38-8

rhodamine 6G

rhodamine 19 (L-methyl-phenylalaninyl)-carbonylmethyl ester bromide

rhodamine 19 (L-methyl-phenylalaninyl)-carbonylmethyl ester bromide

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1.1: 86 percent / 5 h / 265 - 275 °C / vacuum
2.1: 77 percent / NaI; i-Pr2NEt / acetonitrile / 2.5 h / Heating
3.1: 79 percent / H2 / Pd/C / ethanol / 24 h / 20 °C
4.1: N-hydroxysuccinimide; 1,3-dicyclohexylcarbodiimide / dimethylformamide / 0.5 h / 20 °C
4.2: 69 percent / dimethylformamide / 20 °C
View Scheme
rhodamine 6G
989-38-8

rhodamine 6G

rhodamine 19 4-(N-t-butoxycarbonyl-glycinyl-oxymethyl)-1-phenylmethyl ester iodide

rhodamine 19 4-(N-t-butoxycarbonyl-glycinyl-oxymethyl)-1-phenylmethyl ester iodide

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: 86 percent / 5 h / 265 - 275 °C / vacuum
2.1: 88 percent / NaI; i-Pr2NEt / acetonitrile / 2.5 h / Heating
3.1: Cs2CO3 / dimethylformamide / 1 h / 20 °C
3.2: 88 percent / NaI / dimethylformamide / 24 h / 20 °C
View Scheme
rhodamine 6G
989-38-8

rhodamine 6G

rhodamine 19 4-(N-t-butoxycarbonyl-L-valinyl-oxymethyl)-1-phenylmethyl ester iodide

rhodamine 19 4-(N-t-butoxycarbonyl-L-valinyl-oxymethyl)-1-phenylmethyl ester iodide

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: 86 percent / 5 h / 265 - 275 °C / vacuum
2.1: 88 percent / NaI; i-Pr2NEt / acetonitrile / 2.5 h / Heating
3.1: Cs2CO3 / dimethylformamide / 1 h / 20 °C
3.2: 84 percent / NaI / dimethylformamide / 24 h / 20 °C
View Scheme
rhodamine 6G
989-38-8

rhodamine 6G

rhodamine 19 4-(N-benzyloxycarbonyl-L-phenylalaninyl-oxymethyl)-1-phenylmethyl ester iodide

rhodamine 19 4-(N-benzyloxycarbonyl-L-phenylalaninyl-oxymethyl)-1-phenylmethyl ester iodide

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: 86 percent / 5 h / 265 - 275 °C / vacuum
2.1: 88 percent / NaI; i-Pr2NEt / acetonitrile / 2.5 h / Heating
3.1: Cs2CO3 / dimethylformamide / 1 h / 20 °C
3.2: 84 percent / NaI / dimethylformamide / 24 h / 20 °C
View Scheme
rhodamine 6G
989-38-8

rhodamine 6G

rhodamine 19 4-(N-t-butoxycarbonyl-L-isoleucinyl-glycinyl-oxymethyl)-1-phenylmethyl ester iodide

rhodamine 19 4-(N-t-butoxycarbonyl-L-isoleucinyl-glycinyl-oxymethyl)-1-phenylmethyl ester iodide

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: 86 percent / 5 h / 265 - 275 °C / vacuum
2.1: 88 percent / NaI; i-Pr2NEt / acetonitrile / 2.5 h / Heating
3.1: Cs2CO3 / dimethylformamide / 1 h / 20 °C
3.2: 76 percent / NaI / dimethylformamide / 24 h / 20 °C
View Scheme

Basic Red 1 Consensus Reports

IARC Cancer Review: Group 3 IMEMDT    IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man . 7 ,1987,p. 56.(World Health Organization, Internation Agency for Research on Cancer,Lyon, France.: ) (Single copies can be ordered from WHO Publications Centre U.S.A., 49 Sheridan Avenue, Albany, NY 12210) ; Animal Limited Evidence IMEMDT    IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man . 16 ,1978,p. 233.(World Health Organization, Internation Agency for Research on Cancer,Lyon, France.: ) (Single copies can be ordered from WHO Publications Centre U.S.A., 49 Sheridan Avenue, Albany, NY 12210) ; Human No Adequate Data IMEMDT    IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man . 16 ,1978,p. 233.(World Health Organization, Internation Agency for Research on Cancer,Lyon, France.: ) (Single copies can be ordered from WHO Publications Centre U.S.A., 49 Sheridan Avenue, Albany, NY 12210) . Reported in EPA TSCA Inventory. Community Right-To-Know List.

Basic Red 1 Specification

The IUPAC name of Rhodamine 6G Extra Base is [9-(2-ethoxycarbonylphenyl)-6-(ethylamino)-2,7-dimethylxanthen-3-ylidene]-ethylazanium chloride. With the CAS registry number 989-38-8, it is also named as Benzoic acid, 2-(6-(ethylamino)-3-(ethylimino)-2,7-dimethyl-3H-xanthen-9-yl)-, ethyl ester, monohydrochloride; Basic Rhodamine Yellow. The product's categories are analytical chemistry; ion association. It is bright bluish-pink crystals or reddish purple powder which is stable and incompatible with strong oxidizing agents. When heated to decomposition this chemical emits very toxic fumes. The following are the solubility of Rhodamine 6G Extra Base: Butanol (40 g/l), Ethanol (80), Methanol (400), Propanol (15), MEG (50), DEG ( 100), TEG (100), Isopropanol (15), Ethoxyethanol (25), Methoxyethanol (50), Dipropylene glycol (30), PEG (20).

The other characteristics of this product can be summarized as: (1)#H bond acceptors: 5; (2)#H bond donors: 2; (3)#Freely Rotating Bonds: 8; (4)Rotatable Bond Count: 7; (5)Tautomer Count: 2; (6)Exact Mass: 478.202321; (7)MonoIsotopic Mass: 478.202321; (8)Topological Polar Surface Area: 61.5; (9)Heavy Atom Count: 34; (10)Complexity: 823.

Preparation of Rhodamine 6G Extra Base: Using p-cresol, 3-ethylamino and phthalic anhydride as raw materials. First, condensating the two raw materials, and then esterification with ethanol to get the product. 

Uses of Rhodamine 6G Extra Base: It is applied to print silk and silk fabrics directly. It also can be used for coloring of leather and paper and for the preparation of organic pigments. In addition, this chemical can react with phosphorus tungsten molybdenum to get paint of high-class ink.

When you are using this chemical, please be cautious about it as the following:
It is harmful if swallowed. In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. If you want to contact this product, you must wear suitable protective clothing, gloves and eye/face protection.

People can use the following data to convert to the molecule structure. 
1. SMILES: [Cl-].CCOC(=O)c4ccccc4c1c3cc(C)c(NCC)cc3[o+]c2cc(NCC)c(C)cc12;
2. InChI: InChI=1/C28H31N2O3.ClH/c1-6-29-23-15-25-21(13-17(23)4)27(19-11-9-10-12-20(19)28(31)32-8-3)22-14-18(5)24(30-7-2)16-26(22)33-25;/h9-16,29-30H,6-8H2,1-5H3;1H/q+1;/p-1.

The following are the toxicity data which has been tested.

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intraperitoneal 6150ug/kg (6.15mg/kg)   Toxicology Letters. Vol. 51, Pg. 35, 1990.
 
mouse LDLo oral 50mg/kg (50mg/kg) CARDIAC: OTHER CHANGES

LIVER: OTHER CHANGES

BLOOD: OTHER HEMOLYSIS WITH OR WITHOUT ANEMIA		 Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. Vol. 7(2), Pg. 34, 1963.
rat LDLo oral 125mg/kg (125mg/kg)   National Toxicology Program Technical Report Series. Vol. NTP-TR-364, Pg. 1989,

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