Product Name

  • Name

    8,8'-[carbonylbis[imino-3,1-phenylenecarbonylimino(4-methyl-3,1-phenylene)carbonylimino]]bisnaphthalene-1,3,5-trisulphonic acid

  • EINECS
  • CAS No. 145-63-1
  • Density g/cm3
  • Solubility
  • Melting Point 128 °C(Solv: ethyl ether (60-29-7))
  • Formula C51H40 N6 O23 S6
  • Boiling Point °Cat760mmHg
  • Molecular Weight 1297.3
  • Flash Point °C
  • Transport Information
  • Appearance
  • Safety Moderately toxic by intravenous route. Human systemic effects by intravenous route: eye effects. An experimental teratogen. Other experimental reproductive effects. When heated to decomposition it emits very toxic fumes of SOx and NOx.
  • Risk Codes
  • Molecular Structure Molecular Structure of 145-63-1 (8,8'-[carbonylbis[imino-3,1-phenylenecarbonylimino(4-methyl-3,1-phenylene)carbonylimino]]bisnaphthalene-1,3,5-trisulphonic acid)
  • Hazard Symbols
  • Synonyms 1,3,5-Naphthalenetrisulfonicacid,8,8'-[ureylenebis[m-phenylenecarbonylimino(4-methyl-m-phenylene)carbonylimino]]di-(8CI);8,8'-[Ureylenebis[m-phenylenecarbonylimino(4-methyl-m-phenylene)carbonylimino]]di-1,3,5-naphthalenetrisulfonicacid; Farma; Farma 939; Fourneau; Metaret; Naganol; Suramin; Suramine
  • PSA 534.03000
  • LogP 13.66600

Synthetic route

suramin
145-63-1

suramin

3'-azido-2',3'-deoxythymidine
30516-87-1

3'-azido-2',3'-deoxythymidine

suramin-3’-azido-2’,3’-dideoxythymidine

suramin-3’-azido-2’,3’-dideoxythymidine

Conditions
ConditionsYield
With phosphorus pentoxide In N,N-dimethyl-formamide

Bayer 205 Chemical Properties

Following is the structure of Bayer 205 (CAS No.145-63-1):


Molecular Formula: C51H40N6O23S6
Molecular Weight: 1297.28 g/mol
IUPAC NAME: 8-[[4-methyl-3-[[3-[[3-[[2-methyl-5-[(4,6,8-trisulfonaphthalen-1-yl)carbamoyl]phenyl]carbamoyl]phenyl]carbamoylamino]benzoyl]amino]benzoyl]amino]naphthalene-1,3,5-trisulfonic acid 
The chemical synonymous of Bayer 205 (CAS No.145-63-1) are 8,8'-[Carbonylbis[Imino-3,1-Phenylenecarbonylimino(4-Methyl-3,1-Phenylene)Carbonylimino]]Bisnaphthalene-1,3,5-Trisulphonic Acid ; Farma 939 ; Fourneau ; Naphuride ; Suramine
CAS No.: 145-63-1
EINECS: 205-658-4
Density: 1.794 g/cm3 
Index of Refraction: 1.777
Molar Refractivity: 302.38 cm3
Molar Volume: 722.7 cm3
Surface Tension: 105.6 dyne/cm
Classification Code of Bayer 205 (CAS No.145-63-1):  Anthelmintics ; Anti-Infective Agents ; Antinematodal agents ; Antineoplastic agents ; Antiparasitic Agents ; Antiprotozoal Agents ; Drug / Therapeutic Agent ; Human Data ; Reproductive Effect ; Trypanocidal agents

Bayer 205 Toxicity Data With Reference

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
man TDLo intravenous 46mg/kg/5W-I (46mg/kg) SENSE ORGANS AND SPECIAL SENSES: OTHER: EYE New England Journal of Medicine. Vol. 314, Pg. 1455, 1986.
mouse LD50 intravenous 620mg/kg (620mg/kg) KIDNEY, URETER, AND BLADDER: "CHANGES IN TUBULES (INCLUDING ACUTE RENAL FAILURE, ACUTE TUBULAR NECROSIS)" Advances in Pharmacology and Chemotherapy. Vol. 15, Pg. 289, 1978.

Bayer 205 Safety Profile

Moderately toxic by intravenous route. Human systemic effects by intravenous route: eye effects. An experimental teratogen. Other experimental reproductive effects. When heated to decomposition it emits very toxic fumes of SOx and NOx.

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