Berberine hydrochloride supplier

Name
Berberine hydrochloride
EINECS 211-195-9
CAS No. 633-65-8
Article Data18
CAS DataBase
Density 1.654g/cm3
Solubility soluble in cold water
Melting Point 204-206 °C (dec.)
Formula C₂₀H₁₈NO₄.Cl
Boiling Point
Molecular Weight 371.82
Flash Point
Transport Information
Appearance yellow crystalline powder
Safety 24/25-36-26
Risk Codes 20/21/22-36/37/38
Molecular Structure
Hazard Symbols Xn
Synonyms NSC 646666;Benzo[g]-1,3-benzodioxolo[5,6-a]quinolizinium,5,6-dihydro-9,10-dimethoxy-, chloride (9CI);Berberine, chloride (6CI,7CI);Berbinium, 7,8,13,13a-tetradehydro-9,10-dimethoxy-2,3-(methylenedioxy)-,chloride (8CI);Berberinium chloride;
PSA 40.80000
LogP 0.10030

Berberine hydrochloride Chemical Properties

Product Name: Berberine hydrochloride (CAS NO.633-65-8)

Molecular Formula: C₂₀H₁₈NO₄.Cl
Molecular Weight: 371.82g/mol
Mol File: 633-65-8.mol
EINECS: 211-195-9
Appearance: yellow crystalline powder
Melting Point: 204-206 °C (dec.)
H-Bond Donor: 0
H-Bond Acceptor: 5
Structure Descriptors of Berberine hydrochloride (CAS NO.633-65-8):
Canonical SMILES: COC1=C(C2=C[N+]3=C(C=C2C=C1)C4=CC5=C(C=C4CC3)OCO5)OC.[Cl-]
InChI: InChI=1S/C20H18NO4.ClH/c1-22-17-4-3-12-7-16-14-9-19-18(24-11-25-19)8-13
(14)5-6-21(16)10-15(12)20(17)23-2;/h3-4,7-10H,5-6,11H2,1-2H3;1H/q+1;/p-1
InChIKey: VKJGBAJNNALVAV-UHFFFAOYSA-M
Product Categories: Natural Plant Extract

Berberine hydrochloride Uses

An ingredient in some commercial eyewash products.

Berberine hydrochloride Toxicity Data With Reference

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
mouse	LD50	intraperitoneal	37mg/kg (37mg/kg)	BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD BEHAVIORAL: EXCITEMENT LUNGS, THORAX, OR RESPIRATION: DYSPNEA	Journal of Pharmacology and Experimental Therapeutics. Vol. 104, Pg. 253, 1952.
mouse	LD50	oral	> 29586mg/kg (29586mg/kg)	BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)	Kiso to Rinsho. Clinical Report. Vol. 8, Pg. 654, 1974.
mouse	LD50	unreported	30mg/kg (30mg/kg)		Pharmaceutical Chemistry Journal Vol. 22, Pg. 856, 1988.
rat	LD50	intravenous	60mg/kg (60mg/kg)		Zhongguo Yaoxue Zazhi. Chinese Pharmacuetical Journal. Vol. 25, Pg. 335, 1990.
rat	LD50	oral	> 15gm/kg (15000mg/kg)	BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)	Kiso to Rinsho. Clinical Report. Vol. 8, Pg. 654, 1974.

Berberine hydrochloride Consensus Reports

Reported in EPA TSCA Inventory.

Berberine hydrochloride Safety Profile

Safety Information of Berberine hydrochloride (CAS NO.633-65-8):
Hazard Codes: Xn Harmful
Risk Statements: 20/21/22-36/37/38
R20/21/22:Harmful by inhalation, in contact with skin and if swallowed.
R36/37/38:Irritating to eyes, respiratory system and skin.
Safety Statements: 24/25-36-26
S24/25:Avoid contact with skin and eyes.
S36:Wear suitable protective clothing.
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
RIDADR: 1544
WGK Germany: 2
RTECS: DR9866400
F: 3-10
HazardClass: 6.1(b)
PackingGroup: III

Berberine hydrochloride Specification

Berberine hydrochloride , its CAS NO. is 633-65-8, the synonyms are 5,6-Dihydro-9,10-dimethoxybenzo(g)-1,3-benzodioxolo(5,6-a)quinolizinium chloride hydrate ; Benzodioxide ; Berberine chloride ; Berberinium chloride ; Benzo(g)-1,3-benzodioxolo(5,6-a)quinolizinium, 5,6-dihydro-9,10-dimethoxy-, chloride ; Berbinium, 7,8,13,13a-tetradehydro-9,10-dimethoxy-2,3-(methylenedioxy)-, chloride .

Product Name

Berberine hydrochloride