Bis(methanesulfonyl)-D-mannitol supplier

Name
MANNITOL,1,6-DIMETHYLSULPHONATE,D-
EINECS
CAS No. 1187-00-4
Density 1.635g/cm³
Solubility
Melting Point 134-136 °C(Solv: ethanol (64-17-5))
Formula C8H18 O10 S2
Boiling Point 721.3°C at 760 mmHg
Molecular Weight 338.357
Flash Point 390°C
Transport Information
Appearance
Safety Poison by intravenous route. Moderately toxic by intraperitoneal route. Mildly toxic by ingestion. Questionable carcinogen with experimental neoplastigenic data. Mutation data reported. When heated to decomposition it emits toxic fumes of SO_x.
Risk Codes
Molecular Structure
Hazard Symbols
Synonyms Mannitol,1,6-dimethanesulfonate, D- (8CI);1,6-Bis(methanesulfonyl)-D-mannitol;1,6-Dimesyl-D-mannitol;1,6-Dimethanesulfonyl-D-mannitol;CB 2511;1,6-Dimethanesulfonyloxy-1,6-dideoxy-D-mannitol;Busulfan mannitol;D-Mannitol busulfan;D-Mannitol busulphan;MM;Mannitol Myleran;Mannitolbusulfan;Mannogranol;NSC 37538;
PSA 184.42000
LogP -1.45600

Bis(methanesulfonyl)-D-mannitol Chemical Properties

IUPAC Name: (2,3,4,5-tetrahydroxy-6-methylsulfonyloxyhexyl) methanesulfonate
Synonyms of Bis(methanesulfonyl)-D-mannitol (CAS NO.1187-00-4): 1,6-Bis(O-methylsulfonyl)-D-mannitol ; 1,6-Bis(methanesulfonyl)-D-mannitol ; 1,6-Bis-0-methylsulfonyl-D-mannitol ; 1,6-Dimesyl-D-mannitol ; 1,6-Dimethane-sulfonoxy-D-mannitol ; 1,6-Dimethanesulfonate-D-mannitol ; 1,6-Dimethanesulfonoxy-1,6-dideoxy-D-mannitol ; 1,6-Dimethanesulfonyloxy-1,6-dideoxy-D-mannitol ; 1,6-Dimethanesulphonoxy-1,6-dideoxy-D-mannitol ;  2511 C. B. ; AI3-51861 ; Busulfan mannitol ; CB 2511 ; D-Mannitol busulfan ; D-Mannitol busulphan ; D-Mannitol, 1,6-dimethanesulfonoxy-1,6-dideoxy- ; D-Mannitol, 1,6-dimethanesulphonoxy-1,6-dideoxy- ; D-Mannitolbusulphan ; DSM ; Di(methylsulfonoxy)1-6-mannitol ; MM (VAN) ; Mannit-myleran ; Mannitol myleran ; Mannitolbusulfan ; Mannograno ; Mannogranol ; NSC-37538
CAS NO: 1187-00-4
Molecular Formula of Bis(methanesulfonyl)-D-mannitol (CAS NO.1187-00-4): C₈H₁₈O₁₀S₂
Molecular Weight of Bis(methanesulfonyl)-D-mannitol (CAS NO.1187-00-4): 338.3525
H bond acceptors: 10
H bond donors: 4
Freely Rotating Bonds: 13
Polar Surface Area: 140.42 Å²
Index of Refraction: 1.553
Molar Refractivity: 66.25 cm³
Molar Volume: 206.9 cm³
Surface Tension: 76.8 dyne/cm
Density: 1.635 g/cm³
Flash Point: 390 °C
Enthalpy of Vaporization: 120.35 kJ/mol
Boiling Point: 721.3 °C at 760 mmHg
Vapour Pressure: 5.01E-24 mmHg at 25°C
Molecular Structure:

Bis(methanesulfonyl)-D-mannitol Toxicity Data With Reference

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
dog	LDLo	intravenous	135mg/kg (135mg/kg)	BLOOD: LEUKOPENIA BLOOD: AGRANULOCYTOSIS BLOOD: OTHER CHANGES	Cancer Chemotherapy Reports, Part 2. Vol. 2, Pg. 203, 1965.
monkey	LDLo	intravenous	135mg/kg (135mg/kg)	BLOOD: LEUKOPENIA BLOOD: AGRANULOCYTOSIS BLOOD: OTHER CHANGES	Cancer Chemotherapy Reports, Part 2. Vol. 2, Pg. 203, 1965.
mouse	LD50	intraperitoneal	2500mg/kg (2500mg/kg)		Arzneimittel-Forschung. Drug Research. Vol. 17, Pg. 145, 1967.
mouse	LD50	oral	6gm/kg (6000mg/kg)		Arzneimittel-Forschung. Drug Research. Vol. 17, Pg. 145, 1967.
rat	LD50	intraperitoneal	2gm/kg (2000mg/kg)	BLOOD: NORMOCYTIC ANEMIA BLOOD: THROMBOCYTOPENIA	European Journal of Cancer. Vol. 4, Pg. 617, 1968.

Bis(methanesulfonyl)-D-mannitol Consensus Reports

EPA Genetic Toxicology Program.

Bis(methanesulfonyl)-D-mannitol Safety Profile

Poison by intravenous route. Moderately toxic by intraperitoneal route. Mildly toxic by ingestion. Questionable carcinogen with experimental neoplastigenic data. Mutation data reported. When heated to decomposition it emits toxic fumes of SO_x.

Product Name

MANNITOL,1,6-DIMETHYLSULPHONATE,D-

Bis(methanesulfonyl)-D-mannitol Chemical Properties

Bis(methanesulfonyl)-D-mannitol Toxicity Data With Reference

Bis(methanesulfonyl)-D-mannitol Consensus Reports

Bis(methanesulfonyl)-D-mannitol Safety Profile

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