Bosutinib supplier | CasNO.380843-75-4

Name
Bosutinib
EINECS 700-455-1
CAS No. 380843-75-4
Article Data17
CAS DataBase
Density 1.36 g/cm³
Solubility
Melting Point 116-120 °C
Formula C₂₆H₂₉Cl₂N₅O₃
Boiling Point 649.7 °C at 760 mmHg
Molecular Weight 530.454
Flash Point 346.7 °C
Transport Information
Appearance white powder
Safety 26
Risk Codes 36
Molecular Structure
Hazard Symbols Xi
Synonyms 4-[(2,4-dichloro-5-methoxy-phenyl)amino]-6-methoxy-7-[3-(4-methylpiperazin-1-yl)propoxy]quinoline-3-carbonitrile;3-Quinolinecarbonitrile, 4-((2,4-dichloro-5-methoxyphenyl)amino)-6-methoxy-7-(3-(4-methyl-1-piperazinyl)propoxy)-;Bosutinib [USAN];4-((2,4-dichloro-5-methoxyphenyl)amino)-6-methoxy-7-(3-(4-methylpiperazin-1-yl)propoxy)quinoline-3-carbonitrile;SKI-606;Bosutinib(TINIBS );
PSA 82.88000
LogP 5.13918

Bosutinib Specification

1. Introduction of Bosutinib
Bosutinib is one kind of white powder. The IUPAC Name of it is 4-(2,4-Dichloro-5-methoxyanilino)-6-methoxy-7-[3-(4-methylpiperazin-1-yl)propoxy]quinoline-3-carbonitrile. It belongs to API;Aromatics Compounds. It may in EP Standard or Standard Enterprise. The Classification Code of it is Antineoplastic (Src kinase inhibitor); Antineoplastic Agents; Antineoplastic [Src kinase inhibitor].

2. Properties of Bosutinib
Physical properties about Bosutinib are:
(1)Index of Refraction: 1.651; (2)Density: 1.36 g/cm³; (3)Flash Point: 346.7 °C; (4)Melting point: 116-120 °C; (5)Enthalpy of Vaporization: 95.77 kJ/mol; (6)Boiling Point: 649.7 °C at 760 mmHg; (7)Vapour Pressure: 9.15E-17 mmHg at 25 °C.

3. Structure Descriptors of Bosutinib
(1)InChI: InChI=1S/C26H29Cl2N5O3/c1-32-6-8-33(9-7-32)5-4-10-36-25-13-21-18(11-24(25)35-3)26(17(15-29)16-30-21)31-22-14-23(34-2)20(28)12-19(22)27/h11-14,16H,4-10H2,1-3H3,(H,30,31)
(2)InChIKey: InChIKey=UBPYILGKFZZVDX-UHFFFAOYSA-N
(3)Smiles: c1(cc2ncc(C#N)c(Nc3cc(OC)c(Cl)cc3Cl)c2cc1OC)OCCCN1CCN(CC1)C

4. Uses of Bosutinib
Bosutinib (CAS NO.380843-75-4) has been used for API. It is a tyrosine kinase inhibitor undergoing research for use in the treatment of CML. It is also used in the treatment of cancer use in the treatment of cancer. Some commercial stocks of bosutinib have recently been found to have the incorrect chemical structure, calling the biological results obtained with them into doubt.

Product Name

Bosutinib

Bosutinib Specification

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