Product Name

  • Name

    Bumetanide

  • EINECS 249-004-6
  • CAS No. 28395-03-1
  • Density 1.347 g/cm3
  • Solubility Soluble in ethanol (10 mg/ml), DMSO (25 mg/ml), acetone, benzene, methanol, propylene glycol, and water (<1 mg/ml).
  • Melting Point 230-231 °C
  • Formula C17H20N2O5S
  • Boiling Point 571.2 °C at 760 mmHg
  • Molecular Weight 364.422
  • Flash Point 299.3 °C
  • Transport Information
  • Appearance crystalline solid
  • Safety
  • Risk Codes
  • Molecular Structure Molecular Structure of 28395-03-1 (Bumetanide)
  • Hazard Symbols
  • Synonyms Benzoicacid, 3-(butylamino)-4-phenoxy-5-sulfamoyl- (8CI);3-(Aminosulfonyl)-5-(butylamino)-4-phenoxybenzoic acid;3-(Butylamino)-4-phenoxy-5-sulfamoylbenzoic acid;3-n-Butylamino-4-phenoxy-5-sulfamoylbenzoic acid;Bumex;Burinex;Fontego;Fordiuran;Lixil;Lunetoron;PF1593;Ro 10-6338;
  • PSA 127.10000
  • LogP 4.89060

Bumetanide Chemical Properties

Molecular Structure of Bumetanide (CAS NO.28395-03-1):

IUPAC Name: 3-(Butylamino)-4-phenoxy-5-sulfamoylbenzoic acid
Molecular Formula: C17H20N2O5S
Molecular Weight: 364.416100 g/mol
EINECS: 249-004-6
Melting Point: 230-231 °C
Density: 1.347 g/cm3
Flash Point: 299.3 °C
Enthalpy of Vaporization: 90.11 kJ/mol
Boiling Point: 571.2 °C at 760 mmHg
Vapour Pressure: 6.89E-14 mmHg at 25 °C
Water Solubility: 32.22 mg/L at 25 °C
Appearance: Crystalline Solid
Classification Code: Diuretic; Diuretics; Drug / Therapeutic Agent; Membrane Transport Modulators; Natriuretic Agents; Sodium Potassium Chloride Symporter Inhibitors

Bumetanide Uses

 Bumetanide (CAS NO.28395-03-1) is used to treat heart failure. It is often used in patients in whom high doses of furosemide are ineffective with the brand name Bumex.

Bumetanide Toxicity Data With Reference

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
dog LDLo intravenous > 500ug/kg (0.5mg/kg) BEHAVIORAL: TETANY

BEHAVIORAL: MUSCLE CONTRACTION OR SPASTICITY)

KIDNEY, URETER, AND BLADDER: URINE VOLUME INCREASED		 Arzneimittel-Forschung. Drug Research. Vol. 22, Pg. 66, 1972.
dog LDLo oral > 500ug/kg (0.5mg/kg) KIDNEY, URETER, AND BLADDER: URINE VOLUME INCREASED Arzneimittel-Forschung. Drug Research. Vol. 22, Pg. 66, 1972.
mammal (species unspecified) LD50 intravenous 6200ug/kg (6.2mg/kg)   Journal of Clinical Pharmacology. Vol. 21, Pg. 543, 1981.
mouse LD50 intramuscular > 25mg/kg (25mg/kg)   Yakkyoku. Pharmacy. Vol. 27, Pg. 1057, 1976.
mouse LD50 intraperitoneal 519mg/kg (519mg/kg)   Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 7, Pg. 614, 1976.
mouse LD50 intravenous > 200mg/kg (200mg/kg)   Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 7, Pg. 614, 1976.
mouse LD50 oral 4624mg/kg (4624mg/kg)   Drugs in Japan Vol. 6, Pg. 683, 1982.
mouse LD50 subcutaneous 1660mg/kg (1660mg/kg)   Drugs in Japan Vol. 6, Pg. 683, 1982.
rabbit LD50 intravenous 70mg/kg (70mg/kg)   Postgraduate Medical Journal, Supplement. Vol. 51(Suppl,
rabbit LD50 oral 350mg/kg (350mg/kg)   Postgraduate Medical Journal, Supplement. Vol. 51(Suppl,
rat LD50 intramuscular > 5mg/kg (5mg/kg)   Yakkyoku. Pharmacy. Vol. 27, Pg. 1057, 1976.
rat LD50 intraperitoneal 891mg/kg (891mg/kg)   Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 21, Pg. 775, 1979.
rat LD50 intravenous > 200mg/kg (200mg/kg)   Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 7, Pg. 614, 1976.
rat LD50 oral > 6gm/kg (6000mg/kg)   Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 7, Pg. 614, 1976.
rat LD50 subcutaneous > 2gm/kg (2000mg/kg)   Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 7, Pg. 614, 1976.

Bumetanide Safety Profile

Poison by ingestion, subcutaneous, and intravenous routes. Moderately toxic by intraperitoneal route. When heated to decomposition it emits toxic fumes of SOx and NOx.
Safety Information of Bumetanide (CAS NO.28395-03-1):
WGK Germany: 3
RTECS: DG4910000

Bumetanide Specification

 Bumetanide (CAS NO.28395-03-1), its Synonyms are Benzoicacid, 3-(butylamino)-4-phenoxy-5-sulfamoyl- (8CI) ; 3-(Aminosulfonyl)-5-(butylamino)-4-phenoxybenzoic acid ; 3-(Butylamino)-4-phenoxy-5-sulfamoylbenzoic acid ; 3-n-Butylamino-4-phenoxy-5-sulfamoylbenzoic acid ; Bufenox ; Bumex ; Burinex ; Edemex ; Fontego ; Fordiuran ; Lixil ; Lunetoron .

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