Molecular structure of Bupropion hydrochloride (CAS NO.31677-93-7) is:
Product Name: Bupropion hydrochloride
CAS Registry Number: 31677-93-7
IUPAC Name: 2-(tert-butylamino)-1-(3-chlorophenyl)propan-1-one Hydrochloride
Molecular Weight: 276.20206 [g/mol]
Molecular Formula: C13H18ClNO.HCl
H-Bond Donor: 2
H-Bond Acceptor: 2
EINECS: 250-759-9
Melting Point: 233-234 °C
Flash Point: 178.4 °C
Enthalpy of Vaporization: 63.05 kJ/mol
Boiling Point: 371.4 °C at 760 mmHg
Vapour Pressure: 7.09E-06 mmHg at 25°C
Solubility ethanol: 193 mg/mL solutions may be stored for several days at 4 °C.
Product Categories: Aromatics Compounds;Aromatics;Intermediates & Fine Chemicals;Pharmaceuticals;Adrenoceptor
Bupropion hydrochloride (CAS NO.31677-93-7) is a selective inhibitor of dopamine uptake, it is an antidepressant of the aminoketone class. It is also used to aid in smoking cessation.
Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
---|---|---|---|---|---|
man | LDLo | oral | 329mg/kg (329mg/kg) | BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD CARDIAC: PULSE RATE CARDIAC: OTHER CHANGES | Journal of Toxicology, Clinical Toxicology. Vol. 35, Pg. 321, 1997. |
man | TDLo | oral | 2143ug/kg/2D- (2.143mg/kg) | BEHAVIORAL: "HALLUCINATIONS, DISTORTED PERCEPTIONS" BEHAVIORAL: MUSCLE WEAKNESS SKIN AND APPENDAGES (SKIN): "DERMATITIS, OTHER: AFTER SYSTEMIC EXPOSURE" | Annals of Pharmacotherpy. Vol. 33, Pg. 931, 1999. |
man | TDLo | oral | 64mg/kg (64mg/kg) | BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD CARDIAC: EKG CHANGES NOT DIAGNOSTIC OF ABOVE CARDIAC: PULSE RATE INCREASE WITHOUT FALL IN BP | Journal of Toxicology, Clinical Toxicology. Vol. 37, Pg. 634, 1999. |
mouse | LD50 | intraperitoneal | 230mg/kg (230mg/kg) | BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY) BEHAVIORAL: ANALGESIA | Journal of Pharmacy and Pharmacology. Vol. 29, Pg. 767, 1977. |
mouse | LD50 | oral | 544mg/kg (544mg/kg) | BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD LUNGS, THORAX, OR RESPIRATION: DYSPNEA BEHAVIORAL: ATAXIA | Pharmacological and Biochemical Properties of Drug Substances. Vol. 3, Pg. 1, 1981. |
rat | LD50 | intraperitoneal | 210mg/kg (210mg/kg) | BEHAVIORAL: TREMOR BEHAVIORAL: MUSCLE CONTRACTION OR SPASTICITY) | Journal of Pharmacy and Pharmacology. Vol. 29, Pg. 767, 1977. |
rat | LD50 | oral | 482mg/kg (482mg/kg) | BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD BEHAVIORAL: ATAXIA LUNGS, THORAX, OR RESPIRATION: DYSPNEA | Pharmacological and Biochemical Properties of Drug Substances. Vol. 3, Pg. 1, 1981. |
women | TDLo | oral | 2mg/kg (2mg/kg) | BEHAVIORAL: "HALLUCINATIONS, DISTORTED PERCEPTIONS" GASTROINTESTINAL: NAUSEA OR VOMITING BEHAVIORAL: FOOD INTAKE (ANIMAL) | American Journal of Psychiatry. Vol. 142, Pg. 1459, 1985. |
women | TDLo | oral | 20mg/kg (20mg/kg) | BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD | Journal of Clinical Psychiatry. Vol. 54, Pg. 162, 1993. |
women | TDLo | oral | 90mg/kg (90mg/kg) | CARDIAC: EKG CHANGES NOT DIAGNOSTIC OF ABOVE CARDIAC: PULSE RATE INCREASE WITHOUT FALL IN BP | Journal of Toxicology, Clinical Toxicology. Vol. 37, Pg. 634, 1999. |
women | TDLo | oral | 180mg/kg (180mg/kg) | BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD | Journal of Toxicology, Clinical Toxicology. Vol. 37, Pg. 634, 1999. |
women | TDLo | oral | 180mg/kg (180mg/kg) | BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD CARDIAC: PULSE RATE INCREASE WITHOUT FALL IN BP | American Journal of Emergency Medicine. Vol. 12, Pg. 183, 1994. |
Poison by intraperitoneal route. Moderately toxic by ingestion. When heated to decomposition it emits toxic fumes of NOx and Cl−.
Hazard Codes: Xi,Xn
Risk Statements: 22
R22:Harmful if swallowed.
Safety Statements: 36
S36:Wear suitable protective clothing.
WGK Germany: 3
RTECS: UG8858000
Bupropion hydrochloride , its cas register number is 31677-93-7. It also can be called Amfebutamone hydrochloride ; 1-(3-Chlorophenyl)-2-[(1,1-dimethylethyl)amino]-1-propanone hydrochloride ; 2-tert-Butylamino-1-(3-chlorophenyl)-propan-1-one hydrochloride .It is a white crystalline powder.
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