A toxic mixture of organochlorine pesticides stored to some extent in body fat. It resembles chlordane and, to some extent, camphor in its physiological action. It causes diffuse stimulation of the brain and spinal cord resulting in generalized convulsions of a tonic or clonic character. Death usually results from respiratory failure. Detoxification appears to occur in the liver. The lethal ingestion dose for humans is estimated to be 2–7 g, a toxicity of about four times that of DDT. At least seven human deaths have been reported due to toxaphene, all in children. Two families have been made ill by eating vegetables containing a large residue of toxaphene. When heated to decomposition it emits toxic fumes of Cl−.
Analytical Methods:
For occupational chemical analysis use NIOSH: Chlorinated Camphene S67.
1. | skn-mam 500 mg MOD | JAMAAP JAMA, Journal of the American Medical Association. 149 (1952),1135. | ||
2. | mmo-sat 100 µg/plate | ENMUDM Environmental Mutagenesis. 8 (Suppl 7)(1986),1. | ||
3. | mma-sat 500 µg/plate | SCIEAS Science. 205 (1979),591. | ||
4. | sce-hmn:lym 10 µmol/L | ARTODN Archives of Toxicology. 52 (1983),221. | ||
5. | otr-mus:emb 12,400 µg/L | PMRSDJ Progress in Mutation Research. 5 (1985),659. | ||
6. | orl-hmn LDLo:28 mg/kg:CNS | 34ZIAG Toxicology of Drugs and Chemicals, Deichmann, W.B.,New York, NY.: Academic Press, Inc.,1969,598. | ||
7. | orl-man LDLo:29 mg/kg | CMEP** Clinical Memoranda on Economic Poisons US Dept. HEW, Public Health Service, Communicable Disease Center,Atlanta, GA.: 1956,1. | ||
8. | skn-hmn TDLo:657 mg/kg:SKN | CMEP** Clinical Memoranda on Economic Poisons US Dept. HEW, Public Health Service, Communicable Disease Center,Atlanta, GA.: 1956,1. | ||
9. | unr-man LDLo:44 mg/kg | 85DCAI Poisoning; Toxicology, Symptoms, Treatments. 2 (1970),73. | ||
10. | orl-rat LD50:50 mg/kg | & |
A toxic mixture of organochlorine pesticides stored to some extent in body fat. It resembles chlordane and, to some extent, camphor in its physiological action. It causes diffuse stimulation of the brain and spinal cord resulting in generalized convulsions of a tonic or clonic character. Death usually results from respiratory failure. Detoxification appears to occur in the liver. The lethal ingestion dose for humans is estimated to be 2–7 g, a toxicity of about four times that of DDT. At least seven human deaths have been reported due to toxaphene, all in children. Two families have been made ill by eating vegetables containing a large residue of toxaphene. When heated to decomposition it emits toxic fumes of Cl−.
Safety Information of CHLORINATED CAMPHENE(8001-35-2)
Hazard Codes T,N,Xn,F,Xi
Risk Statements 21-25-37/38-40-50/53-67-65-38-11-36/37/38-39/23/24/25-23/24/25
Safety Statements 36/37-45-60-61-62-33-16-36-26
RIDADR 2761
RTECS XW5250000
HazardClass 6.1(b)
PackingGroup III
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