-
Name
CITRININ
- EINECS
- CAS No. 518-75-2
- Article Data12
- CAS DataBase
- Density 1.37g/cm3
- Solubility
- Melting Point 175°C (dec.)
- Formula C13H14 O5
- Boiling Point 440.6°Cat760mmHg
- Molecular Weight 250.251
- Flash Point 170.2°C
- Transport Information
- Appearance yellow crystalline powder or flakes
- Safety Poison by ingestion and other routes. An experimental teratogen. Other experimental reproductive effects. A severe skin irritant. Questionable carcinogen with experimental neoplastigenic and tumorigenic data. Mutation data reported. When heated to decomposition it emits acrid smoke and irritating fumes.
- Risk Codes 23/24/25-40-36/37/38
-
Molecular Structure
- Hazard Symbols T
- Synonyms 3H-2-Benzopyran-7-carboxylicacid, 4,6-dihydro-8-hydroxy-3,4,5-trimethyl-6-oxo-, (3R-trans)-; Citrinin(6CI); (-)-Citrinin;4,6-Dihydro-8-hydroxy-3,4,5-trimethyl-6-oxo-3H-2-benzopyran-7-carboxylic acid;NSC 186
- PSA 83.83000
- LogP 1.72100
CITRININ Chemical Properties
Product Name: Citrinin (CAS NO.518-75-2)
Molecular Formula: C13H14O5
Molecular Weight: 250.25g/mol
Mol File: 518-75-2.mol
Einecs: 208-257-2
Appearance: Yellow crystalline powder or flakes
Melting Point: 175°C (dec.)
Boiling point: 409.8 °C at 760 mmHg
Storage Temperature: 2-8°C
Flash Point: 156.6 °C
Density: 1.37 g/cm3
Surface Tension: 55.9 dyne/cm
Enthalpy of Vaporization: 76.5 kJ/mol
Vapour Pressure: 1.99E-08 mmHg at 25°C
Product Categories: Active Pharmaceutical Ingredients
CITRININ Toxicity Data With Reference
| Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
|---|---|---|---|---|---|
| guinea pig | LD50 | subcutaneous | 37mg/kg (37mg/kg) | LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION | Journal of Pharmacology and Experimental Therapeutics. Vol. 88, Pg. 173, 1946. |
| hamster | LD50 | intraperitoneal | 66mg/kg (66mg/kg) | Food and Cosmetics Toxicology. Vol. 16, Pg. 355, 1978. | |
| hamster | LD50 | oral | 75mg/kg (75mg/kg) | Food and Cosmetics Toxicology. Vol. 16, Pg. 355, 1978. | |
| mouse | LD50 | intraperitoneal | 35mg/kg (35mg/kg) | LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION | Journal of Pharmacology and Experimental Therapeutics. Vol. 88, Pg. 173, 1946. |
| mouse | LD50 | oral | 112mg/kg (112mg/kg) | Toxicology and Applied Pharmacology. Vol. 37, Pg. 139, 1976. | |
| mouse | LD50 | subcutaneous | 73mg/kg (73mg/kg) | Food and Cosmetics Toxicology. Vol. 15, Pg. 29, 1977. | |
| rabbit | LD50 | intraperitoneal | 50mg/kg (50mg/kg) | BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) KIDNEY, URETER, AND BLADDER: "CHANGES IN TUBULES (INCLUDING ACUTE RENAL FAILURE, ACUTE TUBULAR NECROSIS)" | Food and Chemical Toxicology. Vol. 21, Pg. 487, 1983. |
| rabbit | LD50 | intravenous | 19mg/kg (19mg/kg) | SENSE ORGANS AND SPECIAL SENSES: MIOSIS (PUPILLARY CONSTRICTION): EYE GASTROINTESTINAL: CHANGES IN STRUCTURE OR FUNCTION OF SALIVARY GLANDS LUNGS, THORAX, OR RESPIRATION: DYSPNEA | Journal of Pharmacology and Experimental Therapeutics. Vol. 88, Pg. 173, 1946. |
| rabbit | LD50 | oral | 134mg/kg (134mg/kg) | BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA" KIDNEY, URETER, AND BLADDER: "CHANGES IN TUBULES (INCLUDING ACUTE RENAL FAILURE, ACUTE TUBULAR NECROSIS)" | Food and Chemical Toxicology. Vol. 21, Pg. 487, 1983. |
| rat | LD50 | intraperitoneal | 50mg/kg (50mg/kg) | Pharmaceutical Bulletin. Vol. 3, Pg. 337, 1955. | |
| rat | LD50 | subcutaneous | 67mg/kg (67mg/kg) | LUNGS, THORAX, OR RESPIRATION: DYSPNEA LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION BLOOD: OTHER CHANGES | Journal of Pharmacology and Experimental Therapeutics. Vol. 88, Pg. 173, 1946. |
CITRININ Consensus Reports
IARC Cancer Review: Group 3 IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man . 7 , 1987,p. 56.(World Health Organization, Internation Agency for Research on Cancer,Lyon, France.: ) (Single copies can be ordered from WHO Publications Centre U.S.A., 49 Sheridan Avenue, Albany, NY 12210) , Animal Limited Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man . 40 , 1986,p. 67.(World Health Organization, Internation Agency for Research on Cancer,Lyon, France.: ) (Single copies can be ordered from WHO Publications Centre U.S.A., 49 Sheridan Avenue, Albany, NY 12210)
CITRININ Safety Profile
Poison by ingestion and other routes. An experimental teratogen. Other experimental reproductive effects. A severe skin irritant. Questionable carcinogen with experimental neoplastigenic and tumorigenic data. Mutation data reported. When heated to decomposition it emits acrid smoke and irritating fumes.
Safety Information of Citrinin (CAS NO.518-75-2):
Hazard Codes: T.gif){kind=small}
Risk Statements: 23/24/25-40-36/37/38
23: Toxic by inhalation
24: Toxic in contact with skin
25: Toxic if swallowed
36: Irritating to the eyes
37: Irritating to the respiratory system
38: Irritating to the skin
40: Limited evidence of a carcinogenic effect
Safety Statements: 26-36/37/39-45-22-7/9
7: Keep container tightly closed
9: Keep container in a well-ventilated place
22: Do not breathe dust
26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice
36: Wear suitable protective clothing
37: Wear suitable gloves
39: Wear eye/face protection
45: In case of accident or if you feel unwell, seek medical advice immediately (show label where possible)
CITRININ Specification
Citrinin ,its CAS NO. is 518-75-2,the synonyms is Antimycin ; Cit ; Citrinin, penicillium citrinum ; 4,6-Dihydro-8-hydroxy-3,4,5-trimethyl-6-oxo-3h-2-benzopyran-7-carboxylic ; 4,6-Dihydro-8-hydroxy-3,4,5-trimethyl-6-oxo-3h-2-benzopyran-7-carboxylic acid ; (3r,4s)-4,6-Dihydro-8-hydroxy-3,4,5-trimethyl-6-oxo-3h-2-benzopyran-7-carbox ; (3r,4s)-4,6-Dihydro-8-hydroxy-3,4,5-trimethyl-6-oxo-3h-2-benzopyran-7-carboxylic acid .
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