• Name

  CLOPERASTINE

• EINECS
• CAS No. 3703-76-2
• Article Data2
• CAS DataBase
• Density 1.12g/cm³
• Solubility
• Melting Point
• Formula C20H24 Cl N O
• Boiling Point 423.9°Cat760mmHg
• Molecular Weight 329.87
• Flash Point 210.2°C
• Transport Information
• Appearance
• Safety Poison by intraperitoneal route. Moderately toxic by ingestion. When heated to decomposition it emits toxic fumes of Cl⁻ and NO_x.
• Risk Codes
• Molecular Structure
• Hazard Symbols
• Synonyms Piperidine,1-[2-[(p-chloro-a-phenylbenzyl)oxy]ethyl]-(6CI,7CI,8CI); (?à)-Cloperastine;1-[2-[(p-Chloro-a-phenylbenzyl)oxy]ethyl]piperidine;Cloperastine; p-Chlorobenzhydryl 2-(1-piperidyl)ethyl ether
• PSA 12.47000
• LogP 4.86980

Synthetic route

110-89-4

piperidine

5321-46-0, 132301-88-3

(4-chlorophenyl)phenylmethyl 2-chloroethyl ether

3703-76-2

Cloperastine

Conditions

Conditions	Yield
With sodium carbonate at 95℃; for 14h;	80.7%

119-56-2

(4-chlorophenyl)phenylmethanol

3703-76-2

Cloperastine

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: sulfuric acid / toluene / 5 h / Reflux 2: sodium carbonate / 14 h / 95 °C View Scheme

3703-76-2

Cloperastine

84627-04-3

2-<(2'-hydroxy-5'-biphenylyl)carbonyl>benzoic acid

levocloperastine fendizoate

Conditions

Conditions	Yield
In water; acetone for 2h; Solvent; Reflux;	96.2%

745783-97-5

triethyl(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)silane

3703-76-2

Cloperastine

1-(2-(phenyl(4-(triethylsilyl)phenyl)methoxy)ethyl)piperidine

Conditions

Conditions	Yield
With 3,4,7,8-Tetramethyl-o-phenanthrolin; ferrous iodide; sodium t-butanolate In tetrahydrofuran at 120℃; for 12h; Schlenk technique; Glovebox; Inert atmosphere;	88%

3703-76-2

Cloperastine

2-[[[(1,1-dimethylethoxy)carbonyl]amino]methyl]-3-methylbutanoic acid chloromethyl ester

1-[2-[(4-chlorophenyl)phenylmethoxy]ethyl]-1-[[2-[[[(1,1-dimethylethoxy)carbonyl]amino]methyl]-3-methyl-1-oxobutoxy]methyl]piperidinium chloride

Conditions

Conditions	Yield
In dichloromethane at 70℃; for 1h;	85%

3703-76-2

Cloperastine

C20H13(2)H11ClNO*ClH

Conditions

Conditions	Yield
Stage #1: Cloperastine With water-d2; lithium carbonate; triisopropylsilanethiol In 1-methyl-pyrrolidin-2-one at 20℃; Irradiation; Stage #2: With hydrogenchloride In 1-methyl-pyrrolidin-2-one	78%

3703-76-2

Cloperastine

3-[[(1,1-dimethylethoxy)carbonyl]amino]-2,2-dimethylpropanoic acid iodomethyl ester

1-[2-[(4-chlorophenyl)phenylmethoxy]ethyl]-1-[[3-[[(1,1-dimethylethoxy)carbonyl]amino]-2,2-dimethyl-1-oxopropoxy]methyl]piperidinium iodide

Conditions

Conditions	Yield
In dichloromethane at 70℃; for 3h;	78%

3703-76-2

Cloperastine

sodium trimethylsilyldimethylsilanolate

1-(2-(phenyl(4-trimethylsilylphenyl)methoxy)ethyl)piperidine

Conditions

Conditions	Yield
With bis(1,5-cyclooctadiene)nickel (0); Dimethyl(phenyl)phosphine In toluene at 70℃; for 18h; Schlenk technique; Sealed tube;	59%

3703-76-2

Cloperastine

levocloperastine

Conditions

Conditions	Yield
With di-p-anisoyl-L-tartaric acid In ethanol at 60℃; for 2h;

3703-76-2

Cloperastine

C20H13(3)H11ClNO

Conditions

Conditions	Yield
With tritium oxide In 1-methyl-pyrrolidin-2-one at 20℃; Irradiation;

3703-76-2

Cloperastine

(E)-1-ethyl-5,5-dimethyl-2-(4,4,4-trifluorobut-2-enoyl)pyrazolidin-3-one

A

2-((3S)-3-(1-(2-((4-chlorophenyl)(phenyl)methoxy)ethyl)-1,4,5,6-tetrahydropyridin-3-yl)-4,4,4-trifluorobutanoyl)-1-ethyl-5,5-dimethylpyrazolidin-3-one

B

2-(3-(1-(2-((4-chlorophenyl)(phenyl)methoxy)ethyl)-1,4,5,6-tetrahydropyridin-3-yl)-4,4,4-trifluorobutanoyl)-1-ethyl-5,5-dimethylpyrazolidin-3-one

Conditions

Conditions	Yield
With tris(pentafluorophenyl)borate; scandium tris(trifluoromethanesulfonate); 2,6-bis[(4S,6S)-sec-butyl-2-oxazolin-2-yl]pyridine In dichloromethane at 80℃; for 24h; Inert atmosphere; stereoselective reaction;	A n/a B n/a

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CLOPERASTINE Chemical Properties

CLOPERASTINE Toxicity Data With Reference

CLOPERASTINE Safety Profile

CLOPERASTINE Specification