CONVALLATOXIN supplier | CasNO.508-75-8

Name
CONVALLATOXIN
EINECS 208-086-3
CAS No. 508-75-8
Article Data4
CAS DataBase
Density 1.41 g/cm³
Solubility
Melting Point 238-239℃ (water )
Formula C29H42 O10
Boiling Point 757.3 °C at 760 mmHg
Molecular Weight 550.646
Flash Point 247.1 °C
Transport Information
Appearance
Safety Poison by subcutaneous, intravenous, intraduodenal, intraperitoneal, and possibly other routes. When heated to decomposition it emits acrid smoke and fumes.
Risk Codes
Molecular Structure
Hazard Symbols
Synonyms Convallatoxin(6CI,7CI,8CI); Convallaotoxin; Convallaton; Convallatoxine; Convallatoxoside;Convallotoxin; Corglycon; Corglycone; Corglykon; Korglykon; NSC 407808;Strophanthidin a-L-rhamnoside
PSA 162.98000
LogP 0.75000

CONVALLATOXIN Chemical Properties

Product Name: Convallatoxin (CAS NO.508-75-8)

Molecular Formula: C₂₉H₄₂O₁₀
Molecular Weight: 550.64g/mol
Mol File: 508-75-8.mol
Einecs: 208-086-3
Boiling point: 757.3 °C at 760 mmHg
Flash Point: 247.1 °C
Density: 1.41 g/cm³
Surface Tension: 70.3 dyne/cm
Enthalpy of Vaporization: 125.86 kJ/mol
Vapour Pressure: 1.8E-26 mmHg at 25°C
XLogP3: -0.7
H-Bond Donor: 5
H-Bond Acceptor: 10

CONVALLATOXIN Uses

Convallatoxin (CAS NO.508-75-8) is a cardiac drug, similar to digitalis. It is mainly used for acute and chronic heart failure.

CONVALLATOXIN Production

Lily of the valley on the grass part of the whole meal with benzene - ethanol mixture solvent extraction, extract concentration and then with chloroform - ethanol solution of concentrated liquid extract, in turn extracts concentrated, the concentrated solution of water extraction. Concentrated aqueous solution obtained after the cooling, crystallization of a lily of the valley poisoning glycosides crude, crude product recrystallized with methanol that was finished, the lily of the valley-wide grass meal, total yield of 0.01%.

CONVALLATOXIN Toxicity Data With Reference

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
cat	LD50	intraduodenal	2100ug/kg (2.1mg/kg)		Arzneimittel-Forschung. Drug Research. Vol. 8, Pg. 557, 1958.
cat	LD50	intraperitoneal	180ug/kg (0.18mg/kg)		Acta Biologica et Medica Germanica. Vol. 12, Pg. 434, 1964.
cat	LD50	intravenous	74ug/kg (0.074mg/kg)		Journal of Pharmacology and Experimental Therapeutics. Vol. 74, Pg. 223, 1942.
cat	LD50	oral	3650ug/kg (3.65mg/kg)		Arzneimittel-Forschung. Drug Research. Vol. 8, Pg. 557, 1958.
cat	LDLo	unreported	50ug/kg (0.05mg/kg)		Archives Internationales de Pharmacodynamie et de Therapie. Vol. 148, Pg. 471, 1964.
frog	LD50	subcutaneous	440ug/kg (0.44mg/kg)		Arzneimittel-Forschung. Drug Research. Vol. 8, Pg. 557, 1958.
frog	LDLo	intravenous	300ug/kg (0.3mg/kg)		Merck Index. Vol. 10, Pg. 357, 1983.
guinea pig	LD50	intraperitoneal	200ug/kg (0.2mg/kg)		Acta Biologica et Medica Germanica. Vol. 12, Pg. 434, 1964.
guinea pig	LD50	intravenous	185ug/kg (0.185mg/kg)		Arzneimittel-Forschung. Drug Research. Vol. 8, Pg. 557, 1958.
guinea pig	LD50	oral	> 50mg/kg (50mg/kg)		Arzneimittel-Forschung. Drug Research. Vol. 8, Pg. 557, 1958.
guinea pig	LD95	intraduodenal	10490ug/kg (10.49mg/kg)		Arzneimittel-Forschung. Drug Research. Vol. 8, Pg. 557, 1958.
monkey	LDLo	intravenous	90ug/kg (0.09mg/kg)		Arzneimittel-Forschung. Drug Research. Vol. 13, Pg. 412, 1963.
mouse	LD50	intraperitoneal	10mg/kg (10mg/kg)		Archives Internationales de Pharmacodynamie et de Therapie. Vol. 155, Pg. 165, 1965.
mouse	LD50	intravenous	1mg/kg (1mg/kg)		U.S. Army Armament Research & Development Command, Chemical Systems Laboratory, NIOSH Exchange Chemicals. Vol. NX#00462,
mouse	LD50	oral	> 2gm/kg (2000mg/kg)		Arzneimittel-Forschung. Drug Research. Vol. 8, Pg. 557, 1958.
mouse	LD50	subcutaneous	15mg/kg (15mg/kg)		Farmakologiya i Toksikologiya Vol. 44, Pg. 342, 1981.
pig	LDLo	intraduodenal	3170ug/kg (3.17mg/kg)		Arzneimittel-Forschung. Drug Research. Vol. 20, Pg. 229, 1970.
pig	LDLo	intravenous	50ug/kg (0.05mg/kg)		Arzneimittel-Forschung. Drug Research. Vol. 20, Pg. 229, 1970.
pigeon	LDLo	intravenous	248ug/kg (0.248mg/kg)		Arzneimittel-Forschung. Drug Research. Vol. 13, Pg. 412, 1963.
rat	LD50	intravenous	15200ug/kg (15.2mg/kg)	BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD	Arzneimittel-Forschung. Drug Research. Vol. 11, Pg. 848, 1961.

CONVALLATOXIN Safety Profile

Poison by subcutaneous, intravenous, intraduodenal, intraperitoneal, and possibly other routes. When heated to decomposition it emits acrid smoke and fumes.

CONVALLATOXIN Specification

Convallatoxin ,its CAS NO. is 508-75-8,the synonyms is Strophanthin 3alpha-1-rhamnoside ; Strophanthidin alpha-l-rhamnopyranoside ; Strophanthidin a-l-rhamnopyranoside ; Corglykon ; Convallatoxin;20(22),5beta-cardenolid-19-al-3beta,5beta,14beta-triol-3beta-d-[a-1-rhamnopyranoside] ; 5Beta,20[22]-cardenolide-19-one-3beta,5alpha,14-triol-3-[6-deoxy-alpha-l-mannopyranosyl] ; 3Beta,5alpha,14-trihydroxy-19-oxo-5beta,20[22]-cardenolide-3-[6-deoxy-alpha-l-mannopyranosyl] .

Product Name

CONVALLATOXIN