Product Name

  • Name

    CUCURBITACIN B

  • EINECS
  • CAS No. 6199-67-3
  • Density 1.23 g/cm3
  • Solubility
  • Melting Point 184-186oC
  • Formula C32H46O8
  • Boiling Point 699.3 °C at 760 mmHg
  • Molecular Weight 558.712
  • Flash Point 218.7 °C
  • Transport Information
  • Appearance White powder
  • Safety 45-24/25
  • Risk Codes 25
  • Molecular Structure Molecular Structure of 6199-67-3 (CUCURBITACIN B)
  • Hazard Symbols T
  • Synonyms 19-Nor-9b,10a-lanosta-5,23-diene-3,11,22-trione, 2b,16a,20,25-tetrahydroxy-9-methyl-, 25-acetate (7CI,8CI);(+)-Cucurbitacin B;Amarine;Cucurbitacine B;NSC 144154;NSC49451;Cucurbitacin B;[(E,6R)-6-[(2S,8S,9R,10R,13R,14S,16R,17R)-2,16-dihydroxy-4,4,9,13,14-pentamethyl-3,11-dioxo-2,7,8,10,12,15,16,17-octahydro-1H-cyclopenta[a]phenanthren-17-yl]-6-hydroxy-2-methyl-5-oxohept-3-en-2-yl] acetate;Cucurbitacin B hydrate;
  • PSA 138.20000
  • LogP 3.49930

CUCURBITACIN B Chemical Properties

CUCURBITACIN B's Molecular formula: C32H46O8
CUCURBITACIN B's Molar mass: 558.7
Synonyms: (2beta,9beta,10alpha,16alpha,23e)-thyl;19-nor-9-beta,10-alpha-lanosta-5,23-diene-3,11,22-trione,2-beta,16-alpha,20,25;19-nor-9beta,10alpha-lanosta-5,23-diene-3,11,22-trione,2beta,16alpha,20,25-tet;19-norlanosta-5,23-diene-3,11,22-trione,25-(acetyloxy)-2,16,20-trihydroxy-9-me;25-(acetyloxy)-2,16,20-trihydroxy-9-methyl-19-norlanosta-5,23-diene-3,11,22-tr;cucurbitacineb;AMARINE;1,2-DIHYDRO-ALPHA-ELATERIN

CUCURBITACIN B Toxicity Data With Reference

1.    

orl-mus LD50:14 mg/kg

     CTYAD8    Zhongcaoyao. Chinese Herbal Medicine. 23 (1992),605.
2.    

scu-mus LD50:1 mg/kg

     CTYAD8    Zhongcaoyao. Chinese Herbal Medicine. 23 (1992),605.
3.    

ims-mus LD50:2730 µg/kg

     CTYAD8    Zhongcaoyao. Chinese Herbal Medicine. 23 (1992),605.

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intramuscular 2730ug/kg (2.73mg/kg)   Zhongcaoyao. Chinese Traditional and Herbal Medicine. Vol. 23, Pg. 605, 1992.
mouse LD50 oral 14mg/kg (14mg/kg)   Zhongcaoyao. Chinese Traditional and Herbal Medicine. Vol. 23, Pg. 605, 1992.
mouse LD50 subcutaneous 1mg/kg (1mg/kg)   Zhongcaoyao. Chinese Traditional and Herbal Medicine. Vol. 23, Pg. 605, 1992.

CUCURBITACIN B Safety Profile

A poison by ingestion, subcutaneous, and intramuscular routes. When heated to decomposition it emits acrid smoke and irritating vapors.

Safety Info
Symbol:
GHS06
Sign: Danger
hazard declaration: H300
hazard declaration add:  
waring notice: P264; P301 + P310

 

CUCURBITACIN B Specification

Cucurbitacin B is a tetracyclic triterpenoid, which can induce apoptosis in human hepatoma cells. It can also induce DNA damage and autophagy in MCF-7 breast cancer cells. In the wild, watermelons, cucumbers, and muskmelons produce bitter Cucurbitacins to defend against preditors. Humans have bred these fruits to eliminate these compounds thereby yielding fruits that are more appealing to our palate.

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