Product Name

  • Name

    Carbidopa

  • EINECS 642-905-9
  • CAS No. 38821-49-7
  • Article Data3
  • CAS DataBase
  • Density 1.42 g/cm3
  • Solubility
  • Melting Point
  • Formula C10H16N2O5
  • Boiling Point 528.7 °C at 760 mmHg
  • Molecular Weight 244.247
  • Flash Point 273.5 °C
  • Transport Information
  • Appearance
  • Safety
  • Risk Codes
  • Molecular Structure Molecular Structure of 38821-49-7 (Carbidopa)
  • Hazard Symbols
  • Synonyms Benzenepropanoicacid, a-hydrazino-3,4-dihydroxy-a-methyl-, monohydrate, (S)-;Benzenepropanoic acid, a-hydrazino-3,4-dihydroxy-a-methyl-, monohydrate, (aS)- (9CI);Carbidopa monohydrate;
  • PSA 125.04000
  • LogP 0.97380

Carbidopa Chemical Properties

Molecular Structure of Benzenepropanoic acid, a-hydrazinyl-3,4-dihydroxy-a-methyl-, hydrate (1:1), (aS)- (CAS NO.38821-49-7):

IUPAC Name: (2S)-3-(3,4-Dihydroxyphenyl)-2-hydrazinyl-2-methylpropanoic acid hydrate 
Molecular Weight: 244.24444 [g/mol]
Molecular Formula: C10H16N2O5
H-Bond Donor: 6
H-Bond Acceptor: 7 
Density: 1.42 g/cm3
Flash Point: 273.5 °C
Enthalpy of Vaporization: 84.58 kJ/mol
Boiling Point: 528.7 °C at 760 mmHg
Vapour Pressure: 5.27E-12 mmHg at 25 °C
Classification Code: Anti-Dyskinesia Agents; Antiparkinson agents; Central Nervous System Agents; Dopamine agents; Drug / Therapeutic Agent; Enzyme inhibitors; Inhibitor [decarboxylase]; Neurotransmitter Agents
SMILES: O=C(O)C(NN)(Cc1cc(O)c(O)cc1)C.O
InChI: InChI=1/C10H14N2O4.H2O/c1-10(12-11,9(15)16)5-6-2-3-7(13)8(14)4-6;/h2-4,12-14H,5,11H2,1H3,(H,15,16);1H2
InChIKey: QTAOMKOIBXZKND-UHFFFAOYAT

Carbidopa Toxicity Data With Reference

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intraperitoneal 148mg/kg (148mg/kg) SENSE ORGANS AND SPECIAL SENSES: PTOSIS: EYE

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

BEHAVIORAL: ATAXIA		 Toxicology and Applied Pharmacology. Vol. 29, Pg. 181, 1974.
mouse LD50 intravenous 519mg/kg (519mg/kg) SENSE ORGANS AND SPECIAL SENSES: PTOSIS: EYE

BEHAVIORAL: ATAXIA

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)		 Toxicology and Applied Pharmacology. Vol. 29, Pg. 181, 1974.
mouse LD50 oral 1750mg/kg (1750mg/kg) SENSE ORGANS AND SPECIAL SENSES: PTOSIS: EYE

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

BEHAVIORAL: ATAXIA		 Toxicology and Applied Pharmacology. Vol. 29, Pg. 181, 1974.
mouse LD50 subcutaneous 4955mg/kg (4955mg/kg) SENSE ORGANS AND SPECIAL SENSES: PTOSIS: EYE

BEHAVIORAL: ATAXIA

SKIN AND APPENDAGES (SKIN): HAIR: OTHER		 Sankyo Kenkyusho Nempo. Annual Report of Sankyo Research Laboratories. Vol. 28, Pg. 116, 1976.
rabbit LD intravenous > 600mg/kg (600mg/kg) BEHAVIORAL: ATAXIA

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION

KIDNEY, URETER, AND BLADDER: HEMATURIA		 Toxicology and Applied Pharmacology. Vol. 29, Pg. 181, 1974.
rat LD50 intraperitoneal 352mg/kg (352mg/kg) SENSE ORGANS AND SPECIAL SENSES: PTOSIS: EYE

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

BEHAVIORAL: ATAXIA		 Toxicology and Applied Pharmacology. Vol. 29, Pg. 181, 1974.
rat LD50 oral 4810mg/kg (4810mg/kg) SENSE ORGANS AND SPECIAL SENSES: PTOSIS: EYE

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

BEHAVIORAL: ATAXIA		 Toxicology and Applied Pharmacology. Vol. 29, Pg. 181, 1974.
rat LD50 subcutaneous 3428mg/kg (3428mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES

SKIN AND APPENDAGES (SKIN): HAIR: OTHER		 Sankyo Kenkyusho Nempo. Annual Report of Sankyo Research Laboratories. Vol. 28, Pg. 116, 1976

Carbidopa Specification

 Benzenepropanoic acid, a-hydrazinyl-3,4-dihydroxy-a-methyl-, hydrate (1:1), (aS)- (CAS NO.38821-49-7), its Synonyms are (-)-L-alpha-Hydrazino-3,4-dihydroxy-alpha-methylhydrocinnamic acid monohydrate ; Benzenepropanoic acid, alpha-hydrazino-3,4-dihydroxy-alpha-methyl-, monohydrate, (S)- ; Carbidopa hydrate ; Carbidopa-1-wasser ; Lodosyn ; S(-)-alpha-Hydrazino-3,4-dihydroxy-alpha-methylhydrocinnamic acid monohydrate ; Hydrocinnamic acid, (-)-L-alpha-hydrazino-3,4-dihydroxy-alpha-methyl-, monohydrate .

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