Product Name

  • Name

    Cefapirin sodium

  • EINECS 246-194-2
  • CAS No. 24356-60-3
  • Article Data1
  • CAS DataBase
  • Density
  • Solubility
  • Melting Point
  • Formula C17H17N3O6S·2Na
  • Boiling Point 783.9 °C at 760 mmHg
  • Molecular Weight 445.452
  • Flash Point 427.9 °C
  • Transport Information
  • Appearance
  • Safety 26-36
  • Risk Codes 36/37/38-42/43
  • Molecular Structure Molecular Structure of 24356-60-3 (Cefapirin sodium)
  • Hazard Symbols HarmfulXn
  • Synonyms 5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylicacid, 3-(hydroxymethyl)-8-oxo-7-[2-(4-pyridylthio)acetamido]-, acetate (ester),monosodium salt (8CI);5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid,3-[(acetyloxy)methyl]-8-oxo-7-[[(4-pyridinylthio)acetyl]amino]-, monosodiumsalt, (6R,7R)- (9CI);5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid,3-[(acetyloxy)methyl]-8-oxo-7-[[(4-pyridinylthio)acetyl]amino]-, monosodiumsalt, (6R-trans)-;Ambrocef;BLP1322;Brisfirina;Cef-Lak;Cefadyl;Cefaloject;Cefatrexyl;Cephapirin sodium;Cephatrexil;NSC179171;Piricef;Sodium cefapirin;Sodium cephapirin;
  • PSA 179.33000
  • LogP -0.53050

Cefapirin sodium Specification

The Temocillin disodium salt, with the CAS registry number 24356-60-3, is also known as 5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid,3-[(acetyloxy)methyl]-8-oxo-7-[[(4-pyridinylthio)acetyl]amino]-, monosodiumsalt, (6R,7R)- (9CI). Its EINECS number is 246-194-2. This chemical's molecular formula is C17H17N3O6S·2Na and molecular weight is 446.48. What's more, its systematic name is Sodium (6R,7R)-3-(acetoxymethyl)-8-oxo-7-{[(4-pyridinylsulfanyl)acetyl]amino}-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate. Its classification codes are: (1)Antibacterial; (2)Drug / Therapeutic Agent; (3)Human Data; (4)Reproductive Effect. This chemical is a cephalosporin antibiotic, partly plasma-bound, that is effective against gram-negative and gram-positive organisms. 

Physical properties of Temocillin disodium salt are: (1)ACD/LogP: 0.792; (2)# of Rule of 5 Violations: 0; (3)#H bond acceptors: 9; (4)#H bond donors: 2; (5)#Freely Rotating Bonds: 8; (6)Polar Surface Area: 167.71 Å2; (7)Flash Point: 427.9 °C; (8)Enthalpy of Vaporization: 119.63 kJ/mol; (9)Boiling Point: 783.9 °C at 760 mmHg; (10)Vapour Pressure: 6.98E-26 mmHg at 25°C.

When you are using this chemical, please be cautious about it as the following:
This chemical is irritating to eyes, respiratory system and skin. It may cause sensitisation by inhalation and skin contact. In case of contact with eyes, you should rinse immediately with plenty of water and seek medical advice. When using it, you need wear suitable protective clothing.

You can still convert the following datas into molecular structure:
(1)SMILES: [Na+].O=C2N1/C(=C(\CS[C@@H]1[C@@H]2NC(=O)CSc3ccncc3)COC(=O)C)C([O-])=O
(2)Std. InChI: InChI=1S/C17H17N3O6S2.Na/c1-9(21)26-6-10-7-28-16-13(15(23)20(16)14(10)17(24)25)19-12(22)8-27-11-2-4-18-5-3-11;/h2-5,13,16H,6-8H2,1H3,(H,19,22)(H,24,25);/q;+1/p-1/t13-,16-;/m1./s1
(3)Std. InChIKey: VGEOUKPOQQEQSX-OALZAMAHSA-M

The toxicity data is as follows:

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
dog LD50 intravenous 2500mg/kg (2500mg/kg)   Arzneimittel-Forschung. Drug Research. Vol. 29, Pg. 424, 1979.
man TDLo intramuscular 350mg/kg/6D (350mg/kg) BLOOD: AGRANULOCYTOSIS Antimicrobial Agents and Chemotherapy. Vol. 1, Pg. 174, 1972.
man TDLo intravenous 7429ug/kg/8W- (7.429mg/kg) KIDNEY, URETER, AND BLADDER: INTERSTITIAL NEPHRITIS Drug Intelligence and Clinical Pharmacy. Vol. 21, Pg. 380, 1987.
mouse LD50 intraperitoneal 8899mg/kg (8899mg/kg)   Drugs in Japan Vol. 6, Pg. 405, 1982.
mouse LD50 intravenous 4600mg/kg (4600mg/kg)   Arzneimittel-Forschung. Drug Research. Vol. 29, Pg. 424, 1979.
mouse LD50 oral 26088mg/kg (26088mg/kg)   Drugs in Japan Vol. 6, Pg. 405, 1982.
mouse LD50 subcutaneous 13556mg/kg (13556mg/kg)   Drugs in Japan Vol. 6, Pg. 405, 1982.
rabbit LD50 intravenous 3gm/kg (3000mg/kg)   Arzneimittel-Forschung. Drug Research. Vol. 29, Pg. 424, 1979.
rat LD50 intraperitoneal 7850mg/kg (7850mg/kg)   Drugs in Japan Vol. 6, Pg. 405, 1982.
rat LD50 intravenous 4580mg/kg (4580mg/kg)   Arzneimittel-Forschung. Drug Research. Vol. 29, Pg. 424, 1979.
rat LD50 oral 16356mg/kg (16356mg/kg)   Drugs in Japan Vol. 6, Pg. 405, 1982.
rat LD50 subcutaneous > 14400mg/kg (14400mg/kg)   Drugs in Japan Vol. 6, Pg. 405, 1982.

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