Cefazolin sodium salt supplier

Name
Cefazolin sodium salt
EINECS 248-278-4
CAS No. 27164-46-1
Article Data6
CAS DataBase
Density
Solubility 50 mg/mL in water
Melting Point 190 °C
Formula C₁₄H₁₄N₈O₄S₃. Na
Boiling Point
Molecular Weight 476.496
Flash Point
Transport Information
Appearance White to off-white powder
Safety 22-36/37
Risk Codes 20/21/22-36/37/38-42/43
Molecular Structure
Hazard Symbols Xi, Xn
Synonyms 5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylicacid,3-[[(5-methyl-1,3,4-thiadiazol-2-yl)thio]methyl]-8-oxo-7-[(1H-tetrazol-1-ylacetyl)amino]-,monosodium salt, (6R,7R)- (9CI);5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylicacid, 3-[[(5-methyl-1,3,4-thiadiazol-2-yl)thio]methyl]-8-oxo-7-[2-(1H-tetrazol-1-yl)acetamido]-,monosodium salt (8CI);3-[[(5-Methyl-1,3,4-thiadiazol-2-yl)thio]methyl]-8-oxo-7-[2-(1H-tetrazol-1-yl)acetamido]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylicacid sodium salt;Acef;Ancef;Atirin;Biazolina;Bor-Cefazol;Cefacidal;Cefazil;Cefazoliin;Cefazolin sodium;Cefazoline sodium;Cephazolin sodium;Cephazolin sodiumsalt;Firmacef;Gramaxin;Kefzol;Lampocef;Liviclina;Monosodium cafazolin;Reflin;SKF 41558;Sodium cefazolin;Sodium cephazolin;Totacef;Zolicef;Cefazolin sodium salt;
PSA 237.76000
LogP -1.64200

Cefazolin sodium salt Specification

1. Introduction of Cefazolin sodium salt
Cefazolin sodium salt is one kind of white or almost white powder. For being a kind of white to off-white powder, it is stable chemically but is incompatible with strong oxidizing agents. The IUPAC name of it is sodium 3-[(5-methyl-1,3,4-thiadiazol-2-yl)sulfanylmethyl]-8-oxo-7-[[2-(tetrazol-1-yl)acetyl]amino]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate. In addition, its product categories are including Active Pharmaceutical Ingredients; API; Antibiotics for Research and Experimental Use; beta-Lactams (Antibiotics for Research and Experimental Use); Biochemistry; Antibiotic Explorer; Intermediates & Fine Chemicals; Pharmaceuticals; Sulfur & Selenium Compounds; A - KResearch Essentials. The Classification Code of it is Antibacterial [systemic]; Antibiotics; Drug / Therapeutic Agent; Human Data; Reproductive Effect.

2. Properties of Cefazolin sodium salt
Physical properties about Cefazolin sodium salt are:
(1)ACD/LogP: 1.13; (2)# of Rule of 5 Violations: 1; (3)#H bond acceptors: 12; (4)#H bond donors: 2; (5)#Freely Rotating Bonds: 7; (6)Polar Surface Area: 226.14; (7)Exact Mass: 476.011958; (8)MonoIsotopic Mass: 476.011958.

3. Structure Descriptors of Cefazolin sodium salt
(1)Canonical SMILES: CC1=NN=C(S1)SCC2=C(N3C(C(C3=O)NC(=O)CN4C=NN=N4)SC2)C(=O)[O-].[Na+]
(2)InChI: InChI=1S/C14H14N8O4S3.Na/c1-6-17-18-14(29-6)28-4-7-3-27-12-9(11(24)22(12)10(7)13(25)26)16-8(23)2-21-5-15-19-20-21;/h5,9,12H,2-4H2,1H3,(H,16,23)(H,25,26);/q;+1/p-1
(3)InChIKey: FLKYBGKDCCEQQM-UHFFFAOYSA-M

4. Toxicity of Cefazolin sodium salt
Below are the toxicity information of this chemical:

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
dog	LD50	intravenous	2200mg/kg (2200mg/kg)		Arzneimittel-Forschung. Drug Research. Vol. 29, Pg. 424, 1979.
dog	LD50	subcutaneous	4gm/kg (4000mg/kg)	GASTROINTESTINAL: CHANGES IN STRUCTURE OR FUNCTION OF SALIVARY GLANDS GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA" GASTROINTESTINAL: NAUSEA OR VOMITING	Chemotherapy Vol. 18, Pg. 528, 1970.
human	TDLo	intramuscular	14mg/kg/D (14mg/kg)	GASTROINTESTINAL: CHANGES IN STRUCTURE OR FUNCTION OF SALIVARY GLANDS GASTROINTESTINAL: NAUSEA OR VOMITING SKIN AND APPENDAGES (SKIN): "DERMATITIS, ALLERGIC: AFTER SYSTEMIC EXPOSURE"	Japan Medical Gazette. Vol. 8(8), Pg. 10, 1971.
mouse	LD50	intraperitoneal	6200mg/kg (6200mg/kg)		Drugs in Japan Vol. 6, Pg. 404, 1982.
mouse	LD50	intravenous	3900mg/kg (3900mg/kg)		Journal of Infectious Diseases. Vol. 128, Pg. S379, 1973.
mouse	LD50	oral	> 11gm/kg (11000mg/kg)		Chemotherapy Vol. 18, Pg. 528, 1970.
mouse	LD50	subcutaneous	7600mg/kg (7600mg/kg)		Journal of Infectious Diseases. Vol. 128, Pg. S379, 1973.
rabbit	LD50	intravenous	2500mg/kg (2500mg/kg)		Arzneimittel-Forschung. Drug Research. Vol. 29, Pg. 424, 1979.
rabbit	LD50	subcutaneous	> 6gm/kg (6000mg/kg)		Chemotherapy Vol. 18, Pg. 528, 1970.
rat	LD50	intraperitoneal	7400mg/kg (7400mg/kg)		Drugs in Japan Vol. 6, Pg. 404, 1982.
rat	LD50	intravenous	2760mg/kg (2760mg/kg)	BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD BEHAVIORAL: ATAXIA LUNGS, THORAX, OR RESPIRATION: DYSPNEA	Chemotherapy Vol. 35(Suppl,
rat	LD50	oral	> 11gm/kg (11000mg/kg)		Chemotherapy Vol. 18, Pg. 528, 1970.
rat	LD50	subcutaneous	10gm/kg (10000mg/kg)	BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"	Japan Medical Gazette. Vol. 8(8), Pg. 10, 1971.
women	TDLo	intravenous	660mg/kg/11D- (660mg/kg)	BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD	Nephron. Vol. 45, Pg. 72, 1987.

5. Safety information of Cefazolin sodium salt
For one thing, it is irritant to eyes, respiratory system and skin, which may also cause inflammation to the skin or other mucous membranes. For another thing, it is harmful which may cause damage to health. If by inhalation, in contact with skin and if swallowed, it will be very dangerous. Besides, this chemical may cause sensitisation by inhalation and skin contact. Therefore, you should wear suitable protective clothing and gloves. If in case of contact with eyes, rinse immediately with plenty of water and seek medical advice and then remember not to breathe dust.

6. Uses of Cefazolin sodium salt
As to its usage, it is usually used as the semi-synthetic antibiotic derived from 7-amino-cepphalosporanic acid. It also used as an antibacterial. It is one kind of first-generation cephalosporins.

Product Name

Cefazolin sodium salt

Cefazolin sodium salt Specification

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