Product Name

  • Name

    Cefpodoxime proxetil

  • EINECS 1308068-626-2
  • CAS No. 87239-81-4
  • Article Data10
  • CAS DataBase
  • Density 1.58 g/cm3
  • Solubility
  • Melting Point 111-113 °C
  • Formula C21H27N5O9S2
  • Boiling Point
  • Molecular Weight 557.605
  • Flash Point
  • Transport Information
  • Appearance pale yellow solid
  • Safety 22-26-36/37/39
  • Risk Codes 36/37/38-42/43
  • Molecular Structure Molecular Structure of 87239-81-4 (Cefpodoxime proxetil)
  • Hazard Symbols IrritantXi
  • Synonyms 5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylicacid,7-[[(2-amino-4-thiazolyl)(methoxyimino)acetyl]amino]-3-(methoxymethyl)-8-oxo-,1-[[(1-methylethoxy)carbonyl]oxy]ethyl ester, [6R-[6a,7b(Z)]]-;5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid,7-[[(2Z)-(2-amino-4-thiazolyl)(methoxyimino)acetyl]amino]-3-(methoxymethyl)-8-oxo-,1-[[(1-methylethoxy)carbonyl]oxy]ethyl ester, (6R,7R)- (9CI);(RS)-1-(Isopropoxycarbonyloxy)ethyl (+)-(6R,7R)-7-[2-(2-amino-4-thiazolyl)-2-[(Z)-(methoxyimino]acetamido]-3-methoxymethyl-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate;Antibiotic CS 807;Banan;CS 807;CS 807 (pharmaceutical);Cefodox;Cefoprox;Cepodem;Orelox;Otreon;RU 51807;U 76252;Vantin;Cefpodoxime proxetil;
  • PSA 234.51000
  • LogP 1.73700

Cefpodoxime proxetil Specification

 The Cefpodoxime proxetil, with the CAS registry number 87239-81-4,is also known as Vantin; (RS)-1(Isopropoxycarbonyloxy)ethyl (+)-(6R,7R)-7-[2-(2-amino-4-thiazolyl)-2-[(Z)methoxyimino]acetamido]-3-methoxymethyl-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate. It belongs to the product categories of Isotope Labeled Compounds;Metabolites & Impurities;Cefpodoxime. This chemical's molecular formula is C21H27N5O9S2 and molecular weight is 557.59. What's more,Its systematic name is Cefpodoxime proxetil.It is a Pale Yellow Solid which is an antibacterial. A broad spectrum, orally absorbed third generation cephalosporin, ester prodrug of the active free acid metabolite, Cefpodoxime

Physical properties about Cefpodoxime proxetil  are:
(1)ACD/LogP:  2.946; (2)# of Rule of 5 Violations:  2; (3)ACD/LogD (pH 5.5):  2.95; (4)ACD/LogD (pH 7.4):  2.86; (5)ACD/BCF (pH 5.5):  101.75; (6)ACD/BCF (pH 7.4):  84.38; (7)ACD/KOC (pH 5.5):  951.20; (8)ACD/KOC (pH 7.4):  788.76; (9)#H bond acceptors:  14; (10)#H bond donors:  3; (11)#Freely Rotating Bonds:  13; (12)Index of Refraction:  1.671; (13)Molar Refractivity:  131.765 cm3; (14)Molar Volume:  352.527 cm3; (15)Polarizability:  52.236 10-24cm3 ; (16)Surface Tension:  60.0359992980957 dyne/cm; (17)Density:  1.582 g/cm3.

You can still convert the following datas into molecular structure:
(1)SMILES:O=C2N1/C(=C(\CS[C@@H]1[C@@H]2NC(=O)C(=N\OC)/c3nc(sc3)N)COC)C(=O)OC(OC(=O)OC(C)C)C;
(2)Std. InChI:InChI=1S/C21H27N5O9S2/c1-9(2)33-21(30)35-10(3)34-19(29)15-11(6-31-4)7-36-18-14(17(28)26(15)18)24-16(27)13(25-32-5)12-8-37-20(22)23-12/h8-10,14,18H,6-7H2,1-5H3,(H2,22,23)(H,24,27)/b25-13-/t10?,14-,18-/m1/s1;
(3)Std. InChIKey:LTINZAODLRIQIX-FBXRGJNPSA-N.

Safety Information of Cefpodoxime proxetil :
The Cefpodoxime proxetil is irritating to eyes, respiratory system and skin. And it may cause sensitization by inhalation and skin contact. When you use it ,please do not breathe dust and wear suitable protective clothing, gloves and eye/face protection.In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.

The toxicity data of Cefpodoxime proxetil are as follows:

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
dog LD50 oral > 800mg/kg (800mg/kg)   Chemotherapy Vol. 36(Suppl,
mouse LD50 intraperitoneal 2535mg/kg (2535mg/kg) BLOOD: CHANGES IN SPLEEN

LUNGS, THORAX, OR RESPIRATION: DYSPNEA

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)		 Chemotherapy Vol. 36(Suppl,
mouse LD50 oral > 8gm/kg (8000mg/kg)   Chemotherapy Vol. 36(Suppl,
mouse LD50 subcutaneous > 10gm/kg (10000mg/kg) SKIN AND APPENDAGES (SKIN): "DERMATITIS, OTHER: AFTER SYSTEMIC EXPOSURE"

LUNGS, THORAX, OR RESPIRATION: DYSPNEA

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)		 Chemotherapy Vol. 36(Suppl,
rat LD50 intraperitoneal > 4gm/kg (4000mg/kg) BLOOD: CHANGES IN SPLEEN

LUNGS, THORAX, OR RESPIRATION: DYSPNEA

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)		 Chemotherapy Vol. 36(Suppl,
rat LD50 oral > 4gm/kg (4000mg/kg)   Chemotherapy Vol. 36(Suppl,
rat LD50 subcutaneous > 2gm/kg (2000mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

SKIN AND APPENDAGES (SKIN): "DERMATITIS, OTHER: AFTER SYSTEMIC EXPOSURE"

LUNGS, THORAX, OR RESPIRATION: DYSPNEA		 Chemotherapy Vol. 36(Suppl,

Related Products

Hot Products

Post buying leads

About|Contact|Cas|Product Name|Molecular|Country|Encyclopedia

Message|New Cas|MSDS|Service|Advertisement|CAS DataBase|Article Data|Manufacturers | Chemical Catalog

©2008 LookChem.com,License: ICP

NO.:Zhejiang16009103

complaints:service@lookchem.com Desktop View