Cefprozil supplier | CasNO.92665-29-7

Name
Cefprozil
EINECS 618-870-0
CAS No. 92665-29-7
Article Data4
CAS DataBase
Density 1.53 g/cm³
Solubility Soluble in DMSO at 10mg/ml. Insoluble in water.
Melting Point 76°C
Formula C₁₈H₁₉N₃O₅S
Boiling Point 803.1 °C at 760 mmHg
Molecular Weight 389.432
Flash Point 439.5 °C
Transport Information
Appearance white powder
Safety
Risk Codes R22; R41; R43
Molecular Structure
Hazard Symbols Xn
Synonyms 5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2- carboxylic acid,7-[[(2R)-amino(4-hydroxyphenyl) acetyl]amino]-8-oxo-3-(1-propenyl)-,(6R,7R)-;5-Thia-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylic acid, 7-((amino(4-hydroxyphenyl)acetyl)amino)-8-oxo-3-(1-propenyl)-, (6R-(6alpha,7beta(R*)))-;Cefprozilum [INN-Latin];Cefzil (TN);Cefprozil (USP);BMY 28100;(6R,7R)-7-[[(2R)-2-amino-2-(4-hydroxyphenyl)acetyl]amino]-8-oxo-3-[(E)-prop-1-enyl]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid;Cronocef;Cefprozilo [INN-Spanish];CFPZ;Serozil;Brisoral;5-Thia-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylic acid, 7-(((2R)-amino(4-hydroxyphenyl)acetyl)amino)-8-oxo-3-(1-propenyl)-, (6R,7R)-;Cefprozil anhydrous;Cefzil;(6R,7R)-7-[(2R)-2-Amino-2-(4-hydroxyphenyl) acetylamino]-8-oxo-3-(1-pro-penyl)-5-thia-1-azabicylo [4.2.0]oct-2-ene-2-carboxylic acid;
PSA 158.26000
LogP 1.73580

Cefprozil Specification

The Cefprozil, with the CAS registry number 92665-29-7, has the IUPAC name of (6R,7R)-7-[[(2R)-2-amino-2-(4-hydroxyphenyl)acetyl]amino]-8-oxo-3-[(E)-prop-1-enyl]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid. This is usually applied as the cephalosporin type antibiotic and could be used to treat bronchitis, ear infections, skin infections, and other bacterial infections. Besides, its product categories are including Intermediates & Fine Chemicals; Pharmaceuticals.

The physical properties of this chemical are as follows: (1)ACD/LogP: 0.06; (2)# of Rule of 5 Violations: 1; (3)ACD/LogD (pH 5.5): -2.44; (4)ACD/LogD (pH 7.4): -3.23; (5)ACD/BCF (pH 5.5): 1; (6)ACD/BCF (pH 7.4): 1; (7)ACD/KOC (pH 5.5): 1; (8)ACD/KOC (pH 7.4): 1; (9)#H bond acceptors: 8; (10)#H bond donors: 5; (11)#Freely Rotating Bonds: 7; (12)Polar Surface Area: 104.69; (13)Index of Refraction: 1.718; (14)Molar Refractivity: 100.11 cm³; (15)Molar Volume: 253.8 cm³; (16)Polarizability: 39.68 ×10^-24 cm³; (17)Surface Tension: 85.2 dyne/cm; (18)Density: 1.53 g/cm³; (19)Flash Point: 439.5 °C; (20)Enthalpy of Vaporization: 122.44 kJ/mol; (21)Boiling Point: 803.1 °C at 760 mmHg; (22)Vapour Pressure: 3.18E-27 mmHg at 25°C; (23)Exact Mass: 389.104541; (24)MonoIsotopic Mass: 389.104541; (25)Topological Polar Surface Area: 158; (26)Heavy Atom Count: 27; (27)Complexity: 699.

In addition, you could convert the following datas into the molecular structure:
(1)Canonical SMILES: CC=CC1=C(N2C(C(C2=O)NC(=O)C(C3=CC=C(C=C3)O)N)SC1)C(=O)O
(2)Isomeric SMILES: C/C=C/C1=C(N2[C@@H]([C@@H](C2=O)NC(=O)[C@@H](C3=CC=C(C=C3)O)N)SC1)C(=O)O
(3)InChI: InChI=1S/C18H19N3O5S/c1-2-3-10-8-27-17-13(16(24)21(17)14(10)18(25)26)20-15(23)12(19)9-4-6-11(22)7-5-9/h2-7,12-13,17,22H,8,19H2,1H3,(H,20,23)(H,25,26)/b3-2+/t12-,13-,17-/m1/s1
(4)InChIKey: WDLWHQDACQUCJR-ZAMMOSSLSA-N

Below are the toxicity information of this chemical:

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
child	TDLo	oral	7500ug/kg/5D- (7.5mg/kg)	LUNGS, THORAX, OR RESPIRATION: CHRONIC PULMONARY EDEMA MUSCULOSKELETAL: JOINTS	Journal of Pediatrics. Vol. 125, Pg. 325, 1994.
dog	LD	oral	> 2gm/kg (2000mg/kg)		Japanese Journal of Antibiotics. Vol. 43, Pg. 1238, 1990.
rat	LD	oral	> 2gm/kg (2000mg/kg)		Japanese Journal of Antibiotics. Vol. 43, Pg. 1238, 1990.
women	TDLo	oral	100mg/kg/5D-I (100mg/kg)	MUSCULOSKELETAL: JOINTS SKIN AND APPENDAGES (SKIN): "DERMATITIS, OTHER: AFTER SYSTEMIC EXPOSURE"	Journal of Pediatrics. Vol. 125, Pg. 325, 1994.

Product Name

Cefprozil

Cefprozil Specification

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