Product Name

  • Name

    Chloramphenicol hemisuccinate

  • EINECS 222-590-0
  • CAS No. 3544-94-3
  • Article Data8
  • CAS DataBase
  • Density 1.536g/cm3
  • Solubility
  • Melting Point 127 °C
  • Formula C15H16 Cl2 N2 O8
  • Boiling Point 716.3°Cat760mmHg
  • Molecular Weight 423.207
  • Flash Point 387°C
  • Transport Information
  • Appearance
  • Safety Moderately toxic by subcutaneous, intravenous, and intraperitoneal routes. Experimental reproductive effects. When heated to decomposition it emits toxic fumes of Cl− and NOx. See also other chloramphenicol entries.
  • Risk Codes
  • Molecular Structure Molecular Structure of 3544-94-3 (Chloramphenicol hemisuccinate)
  • Hazard Symbols
  • Synonyms Butanedioicacid, mono[2-[(dichloroacetyl)amino]-3-hydroxy-3-(4-nitrophenyl)propyl] ester,[R-(R*,R*)]-; Succinic acid, ester with chloramphenicol (6CI); Succinic acid, a-monoester withD-threo-(-)-2,2-dichloro-N-[b-hydroxy-a-(hydroxymethyl)-p-nitrophenethyl]acetamide(8CI); Acetamide, 2,2-dichloro-N-[b-hydroxy-a-(hydroxymethyl)-p-nitrophenethyl]-,a-(hydrogen succinate),D-(-)-threo- (8CI); Chloramphenicol 3-monosuccinate; Chloramphenicol acidsuccinate; Chloramphenicol hemisuccinate; Chloramphenicol hydrogen succinate;Chloramphenicol monosuccinate; Chloramphenicol succinate; Chloromycetinsuccinate; Chronicin foam; Kemicetine succinate; Levomycetin hemisuccinate;Levomycetin succinate; Paraxin succinate
  • PSA 162.24000
  • LogP 2.68820

Chloramphenicol hemisuccinate Chemical Properties

IUPAC Name: 4-[2-[(2,2-Dichloroacetyl)amino]-3-hydroxy-3-(4-nitrophenyl)propoxy]-4-oxobutanoic acid
Synonyms of Chloramphenicol succinate (CAS NO.3544-94-3) : (2-((Dichloroacetyl)amino)-3-hydroxy-3-(4-nitrophenyl)propyl) hydrogen (R-(R*,R*))-succinate ; Chloramphenicol acid succinate ; Chloramphenicol hydrogen succinate ; Chloramphenicol monosuccinate
CAS NO:3544-94-3
Molecular Formula:C15H16Cl2N2O8
Molecular Weight :423.2021
Molecular Structure :
EINECS: 222-590-0
Index of Refraction: 1.589
Surface Tension: 65.7 dyne/cm
Density: 1.536 g/cm3
Flash Point: 387 °C
Enthalpy of Vaporization: 109.91 kJ/mol
Boiling Point: 716.3 °C at 760 mmHg
Vapour Pressure: 1.56E-21 mmHg at 25°C

Chloramphenicol hemisuccinate Uses

 Chloramphenicol succinate (CAS NO.3544-94-3) is used as  intermediate in organic synthesis.

Chloramphenicol hemisuccinate Toxicity Data With Reference

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
guinea pig LD50 intravenous 1gm/kg (1000mg/kg)   Farmaco, Edizione Scientifica. Vol. 9, Pg. 21, 1954.
mouse LD50 intraperitoneal 1400mg/kg (1400mg/kg)   Farmaco, Edizione Scientifica. Vol. 9, Pg. 21, 1954.
mouse LD50 intravenous 1500mg/kg (1500mg/kg)   Farmaco, Edizione Scientifica. Vol. 9, Pg. 21, 1954.
mouse LD50 oral 11gm/kg (11000mg/kg)   Kiso to Rinsho. Clinical Report. Vol. 4, Pg. 135, 1970.
mouse LD50 subcutaneous 4200mg/kg (4200mg/kg)   Kiso to Rinsho. Clinical Report. Vol. 4, Pg. 135, 1970.
rat LD50 intravenous 1720mg/kg (1720mg/kg)   Therapie. Vol. 22, Pg. 1405, 1967.
rat LD50 oral 8300mg/kg (8300mg/kg)   Kiso to Rinsho. Clinical Report. Vol. 4, Pg. 135, 1970.
rat LD50 subcutaneous 2400mg/kg (2400mg/kg)   Therapie. Vol. 22, Pg. 1405, 1967.

Chloramphenicol hemisuccinate Consensus Reports

EPA Genetic Toxicology Program.

Chloramphenicol hemisuccinate Safety Profile

Moderately toxic by subcutaneous, intravenous, and intraperitoneal routes. Experimental reproductive effects. When Chloramphenicol succinate (CAS NO.3544-94-3) is heated to decomposition, it emits toxic fumes of Cl− and NOx. See also other chloramphenicol entries.

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