Chlorodifluoroacetamide

The Chlorodifluoroacetamide, with the CAS registry number 354-28-9, is also known as Acetamide,2-chloro-2,2-difluoro-. Its EINECS number is 206-555-7. This chemical's molecular formula is C₂H₂ClF₂NO and molecular weight is 129.49. What's more, its systematic name is 2-chloro-2,2-difluoroacetamide.

Physical properties of Chlorodifluoroacetamide are: (1)ACD/LogP: 0.57; (2)# of Rule of 5 Violations: 0; (3)ACD/LogD (pH 5.5): 0.57; (4)ACD/BCF (pH 5.5): 1.59; (5)ACD/KOC (pH 5.5): 48.49; (6)ACD/KOC (pH 7.4): 48.48; (7)#H bond acceptors: 2; (8)#H bond donors: 2; (9)#Freely Rotating Bonds: 1; (10)Polar Surface Area: 20.31 Å²; (11)Index of Refraction: 1.388; (12)Molar Refractivity: 20.02 cm³; (13)Molar Volume: 84.6 cm³; (14)Surface Tension: 30.1 dyne/cm; (15)Density: 1.529 g/cm³; (16)Flash Point: 67.9 °C; (17)Enthalpy of Vaporization: 42.49 kJ/mol; (18)Boiling Point: 188.7 °C at 760 mmHg; (19)Vapour Pressure: 0.591 mmHg at 25°C.

Uses of Chlorodifluoroacetamide: it can be used to produce 2-chloro-N-[(2-chloro-2,2-difluoro-acetylamino)-phenyl-methyl]-2,2-difluoro-acetamide at the temperature of 5 °C. It will need reagent CF₃SO₃H and solvent CH₂Cl₂ with the reaction time of 24 hours. The yield is about 84%.

When you are using this chemical, please be cautious about it as the following:
It is harmful by inhalation, in contact with skin and if swallowed. It is irritating to eyes, respiratory system and skin. In case of contacting with eyes, you should rinse immediately with plenty of water and seek medical advice. When using it, you need wear suitable protective clothing.

You can still convert the following datas into molecular structure:
(1)Canonical SMILES: C(=O)(C(F)(F)Cl)N
(2)InChI: InChI=1S/C2H2ClF2NO/c3-2(4,5)1(6)7/h(H2,6,7)
(3)InChIKey: PSAKKOKLSDIKEK-UHFFFAOYSA-N