Chlorquinaldol supplier | CasNO.72-80-0

Name
5,7-Dichloro-8-hydroxyquinaldine
EINECS 200-789-3
CAS No. 72-80-0
Article Data17
CAS DataBase
Density 1.467 g/cm³
Solubility insoluble in water
Melting Point 108-112 °C (dec.)(lit.)
Formula C₁₀H₇Cl₂NO
Boiling Point 350.7 °C at 760 mmHg
Molecular Weight 228.078
Flash Point 165.9 °C
Transport Information UN 2811 6.1/PG 3
Appearance yellowish to beige-brown powder
Safety 26-36-36/37/39-45
Risk Codes 22-36/37/38-23/24/25
Molecular Structure
Hazard Symbols Xn,T
Synonyms 5,7-Dichloro-2-methyl-8-hydroxyquinoline;5,7-Dichloro-2-methyl-8-quinolinol;5,7-Dichloro-2-styrylquinoline;5,7-Dichloro-8-hydroxy-2-methylquinoline;5,7-Dichloro-8-hydroxyquinaldine;5,7-Dichloro-8-quinaldinol;Chloquinan;Chlorchinaldin;Chlorguinaldon;Florabina;Gyno-Sterosan;Gynotherax;Hydroxydichloroquinaldinol;Intensol;Quesil;Saprosan;Siogen;Siogenal;Siogene;Siogeno;Siogenon;Siosept;Siosteran;Sterosan;Steroxin;Sterozan;Vagisteran;
PSA 33.12000
LogP 3.55560

Synthetic route

: 826-81-3
2-methyl-8-quinolinol

: 72-80-0
chloroquinaldol

Conditions

Conditions	Yield
With aluminum (III) chloride; N-chloro-succinimide In dichloromethane at 35℃; for 8h; Temperature; Solvent; Darkness; Green chemistry;	98.8%
With hydrogenchloride; chlorine In water Reagent/catalyst; Inert atmosphere; Darkness;	98.9%
With hydrogenchloride; sodium hypochlorite In water at 20 - 30℃; for 4.5h; Temperature;	97.7%

: 21168-33-2
5,7-dichloro-8-hydroxyquinoline 1-oxide

: 676-58-4
methylmagnesium chloride

: 72-80-0
chloroquinaldol

Conditions

Conditions	Yield
With copper(l) chloride; magnesium chloride In diethyl ether at 23℃; for 12h; Grignard Reaction; Inert atmosphere;	63%

: 826-81-3
2-methyl-8-quinolinol

: 4369-36-2
dichlorohydantoin

: 72-80-0
chloroquinaldol

Conditions

Conditions	Yield
With acetic acid for 3h; Cooling with ice;

: 72-80-0
chloroquinaldol

: 24010-07-9
5,7-dichloro-8-hydroxy-2-quinolinecarboxaldehyde

Conditions

Conditions	Yield
With selenium(IV) oxide In 1,4-dioxane at 50 - 80℃; for 3h;	100%
With selenium(IV) oxide In 1,4-dioxane at 80℃; for 12h;	80%
With selenium(IV) oxide In 1,4-dioxane at 55 - 80℃;	2.1 g
With selenium(IV) oxide In 1,4-dioxane at 80℃; for 12h;

: 72-80-0
chloroquinaldol

: 5,7-dichloro-2-methyl-quinoline-8-oxysulfonyl fluoride

Conditions

Conditions	Yield
Stage #1: chloroquinaldol With triethylamine In acetonitrile at 20℃; for 0.166667h; Stage #2: With 1-(fluorosulfuryl)-2,3-dimethyl-1H-imidazol-3-ium trifluoromethanesulfonate In acetonitrile for 1h;	97%
Stage #1: chloroquinaldol With triethylamine In acetonitrile at 20℃; for 0.166667h; Stage #2: With 1-(fluorosulfuryl)-2,3-dimethyl-1H-imidazol-3-ium trifluoromethanesulfonate In acetonitrile for 1h; Inert atmosphere;	97%

: 72-80-0
chloroquinaldol

: 4923-85-7
tert-butylphenylphosphinic acid chloride

: 1227180-25-7
5,7-dichloro-2-methylquinolin-8-yl tert-butyl(phenyl)posphinate

Conditions

Conditions	Yield
With sodium hydride In tetrahydrofuran for 24h; Reflux; Inert atmosphere;	96%

: {Ir(mppy)2Cl}2

: 72-80-0
chloroquinaldol

: C34H26Cl2IrN3O

Conditions

Conditions	Yield
In ethanol; acetone at 85℃; for 5h; Solvent; Temperature;	95.3%

: diiodo(p-cymene)ruthenium(II) dimer

: 72-80-0
chloroquinaldol

: [(η6-p-cymene)Ru(2-methyl-5,7-dichloro-8-hydroxyquinolinato)I]

Conditions

Conditions	Yield
In methanol; dichloromethane at 65℃; for 6h; Reflux;	95.2%

: 72-80-0
chloroquinaldol

: 75992-73-3, 25794-47-2, 30729-25-0, 15274-33-6, 22840-91-1, 14568-13-9
cis-dichlorobis(dimethylsulfoxide)platinum(II)

: C12H12Cl3NO2PtS

Conditions

Conditions	Yield
In methanol; dimethyl sulfoxide at 80℃; for 12h; Solvent; Temperature;	95%

: 72-80-0
chloroquinaldol

: 74-88-4
methyl iodide

: 1053246-24-4
5,7-dichloro-8-methoxy-2-methylquinoline

Conditions

Conditions	Yield
Stage #1: chloroquinaldol With potassium tert-butylate In tetrahydrofuran for 3h; Reflux; Inert atmosphere; Stage #2: methyl iodide In tetrahydrofuran at 20℃; for 6h; Inert atmosphere;	94%
With sodium hydroxide; tetrabutylammomium bromide In tetrahydrofuran at 40℃; for 30h;	83%

: 72-80-0
chloroquinaldol

: 26153-38-8
3,5-dihydroxybenzaldehyde

: 1251918-08-7
5,7-dichloro-2-[2-(3,5-dihydroxyphenyl)vinyl]quinolin-8-ol

Conditions

Conditions	Yield
Stage #1: chloroquinaldol; 3,5-dihydroxybenzaldehyde With acetic anhydride for 24h; Reflux; Stage #2: With pyridine In water for 3h; Reflux;	93%

: 72-80-0
chloroquinaldol

: 64418-88-8
2-hydroxy-5-acetyloxybenzaldehyde

: 5,7-dichloro-2-[2-(2-hydroxy-5-acetoxyphenyl)vinyl]quinolin-8-ol

Conditions

Conditions	Yield
Stage #1: chloroquinaldol; 2-hydroxy-5-acetyloxybenzaldehyde With acetic anhydride for 24h; Reflux; Stage #2: With pyridine In water for 3h; Reflux;	93%

: 12354-84-6, 12354-85-7
bis[dichloro(pentamethylcyclopentadienyl)iridium(III)]

: 72-80-0
chloroquinaldol

: C20H21Cl3IrNO

Conditions

Conditions	Yield
With potassium carbonate In dichloromethane at 20℃; under 760.051 Torr; for 12h;	93%

: 72-80-0
chloroquinaldol

: 76143-12-9
5-acetoxy-2-nitro-benzaldehyde

: (E)-2-(5-acetoxy-2-nitrostyryl)-5,7-dichloroquinolin-8-yl acetate

Conditions

Conditions	Yield
at 150℃;	92%

: 72-80-0
chloroquinaldol

: 108-24-7
acetic anhydride

: 27039-48-1
8-acetoxy-5,7-dichloro-2-methylquinoline

Conditions

Conditions	Yield
With pyridine at 0 - 20℃; for 6h;	91%

: 72-80-0
chloroquinaldol

: 8-hydroxy-5,7-dichloro-2-(d3)methylquinoline

Conditions

Conditions	Yield
With water-d2; benzoic acid at 120℃; for 4h;	91%
With water-d2; benzoic acid at 120℃; for 16h; Inert atmosphere; Schlenk technique;

: 72-80-0
chloroquinaldol

: 552-89-6
2-nitro-benzaldehyde

: (E)-5,7-dichloro-2-(2-nitrostyryl)quinolin-8-yl acetate

Conditions

Conditions	Yield
at 150℃;	91%

: 72-80-0
chloroquinaldol

: 100-39-0
benzyl bromide

: 24010-00-2
8-(benzyloxy)-5,7-dichloro-2-methylquinoline

Conditions

Conditions	Yield
With potassium carbonate In acetone for 5h; Reflux;	91%

: 72-80-0
chloroquinaldol

: 528-75-6
2,4-dinitrobenzaldehyde

: 108-24-7
acetic anhydride

: 5,7-dichloro-2-[2-(2,4-dinitrophenyl)vinyl]quinolin-8-yl acetate

Conditions

Conditions	Yield
With acetic acid at 130℃; Inert atmosphere;	91%

...Expand

: 5394-23-0
4,7-dichloro-1,10-phenanthroline

: 72-80-0
chloroquinaldol

cobalt(II) salt: cobalt(II) salt

: C32H18Cl6CoN4O2

Conditions

Conditions	Yield
In methanol; acetonitrile at 80℃; for 24h;	90.8%

...Expand

: 72-80-0
chloroquinaldol

: 217-90-3
dipyrazine[2,3-f:2’,3’-h]quinoxaline

cobalt(II) salt: cobalt(II) salt

: C34H20Cl4CoN6O2

Conditions

Conditions	Yield
In methanol; acetonitrile at 80℃; for 24h;	90.5%

...Expand

: [iridium(III)(μ-chloro)(2-phenylpyridine)2]2

: 72-80-0
chloroquinaldol

: C32H22Cl2IrN3O

Conditions

Conditions	Yield
In ethanol; water at 70℃; for 12h; Solvent; Temperature;	90.21%

: 13755-29-8
sodium tetrafluoroborate

: [RuCl2(hexamethylbenzene)]2

: 72-80-0
chloroquinaldol

: 1202404-57-6
[(η6-hexamethylbenzene)Ru(η2-N,O-5,7-dichloro-2-methyl-8-hydroxyquinolate)(H2O)]BF4

Conditions

Conditions	Yield
With Ag2SO4 In water under inert atm.; mixt. of ((C6(CH3)6)RuCl2)2 (0.082 mmol) and Ag2SO4 (0.163 mmol) in H2O stirred for 2 h in dark at room temp., soln. filtered,NC9H3Cl2MeOH (0.163 mmol) added, stirred for 2 h in dark at room temp., pptd. by satd. aq. soln. of NaBF4; crystd. from H2O; elem. anal.;	90%

...Expand

: 72-80-0
chloroquinaldol

: 24424-99-5
di-tert-butyl dicarbonate

: tert-butyl (5,7-dichloro-2-methylquinolin-8-yl)carbonate

Conditions

Conditions	Yield
With dmap; triethylamine In tetrahydrofuran at 80℃; for 12h; Inert atmosphere;	90%
With dmap; triethylamine In tetrahydrofuran at 80℃; for 12h; Inert atmosphere;	90%

: 19535-47-8
dipyridil[3,2-a:2',3'-c]phenazine

: 72-80-0
chloroquinaldol

cobalt(II) salt: cobalt(II) salt

: C38H22Cl4CoN6O2

Conditions

Conditions	Yield
In methanol; acetonitrile at 80℃; for 24h;	89.2%

...Expand

: 1134-35-6
4,4'-dimethyl-2,2'-bipyridines

: 72-80-0
chloroquinaldol

: ytterbium(III) nitrate hexahydrate

: [Yb(4,4'-dimethyl-2,2'-bipyridyl)(ClQ)2NO3]

Conditions

Conditions	Yield
at 80℃; for 72h;	89.11%

...Expand

: 72-80-0
chloroquinaldol

: 1309272-63-6
2,4-dichloro-6-formylphenyl acetate

: 108-24-7
acetic anhydride

: 5,7-dichloro-2-[2-(2-acetoxy-3,5-dichlorophenyl)vinyl]quinolin-8-yl acetate

Conditions

Conditions	Yield
With acetic acid at 130℃; Inert atmosphere;	88%

...Expand

: 72-80-0
chloroquinaldol

: 90-02-8
salicylaldehyde

: 1415220-29-9
5,7-dichloro-2-[2-(2-hydroxyphenyl)vinyl]quinolin-8-ol

Conditions

Conditions	Yield
Stage #1: chloroquinaldol; salicylaldehyde With acetic anhydride for 24h; Reflux; Stage #2: With pyridine In water for 3h; Reflux;	87%

: 72-80-0
chloroquinaldol

: 1445-79-0
trimethyl gallium

: (5,7-dichloro-2-methyl-8-quinolinolato)dimethyl gallium

Conditions

Conditions	Yield
In toluene at 24.84℃; for 16h; Inert atmosphere;	87%

: 72-80-0
chloroquinaldol

: 63504-03-0
5,7-dichloro-8-hydroxy-2-methylquinoline 1-oxide

Conditions

Conditions	Yield
With phosphoric acid; dihydrogen peroxide; molybdenum(VI) oxide In water; acetonitrile at 50℃;	87%

: 72-80-0
chloroquinaldol

: 395-81-3
5-fluoro-2-nitrobenzaldehyde

: (E)-5,7-dichloro-2-(5-fluoro-2-nitrostyryl)quinolin-8-yl acetate

Conditions

Conditions	Yield
at 150℃;	87%

: 72-80-0
chloroquinaldol

: 20357-25-9
2-nitroveratraldehyde

: (E)-5,7-dichloro-2-(4,5-dimethoxy-2-nitrostyryl)quinolin-8-yl acetate

Conditions

Conditions	Yield
at 150℃;	87%

Chlorquinaldol Chemical Properties

The molecular formula of CHLOROQUINALDOL(72-80-0) is C₁₀H₇Cl₂NO and its formula weight is 228.07.
The density of CHLOROQUINALDOL(72-80-0) is and it has a melting point of 108-112 °C (dec.)(lit.).
The chemical synonyms of CHLOROQUINALDOL(72-80-0) are 5,7-Dichloro-2-methyl-8-hydroxyquinoline;5,7-dichloro-2-methyl-8-quinolino;8-Quinolinol, 5,7-dichloro-2-methyl-;Afungil;Chloquinan;Chlorchinaldin;Chlorchinaldol;Chlorguinaldon
The molecular structure of CHLOROQUINALDOL(72-80-0) :

Chlorquinaldol Toxicity Data With Reference

1.	orl-rat LD50:660 mg/kg	29ZVAB Handbook of Analytical Toxicology ,Sunshine, I., ed.,Cleveland, OH.: Chemical Rubber Co.,1969,33.
2.	orl-dog LD50:2250 mg/kg	29ZVAB Handbook of Analytical Toxicology ,Sunshine, I., ed.,Cleveland, OH.: Chemical Rubber Co.,1969,33.
3.	orl-rbt LD50:160 mg/kg	29ZVAB Handbook of Analytical Toxicology ,Sunshine, I., ed.,Cleveland, OH.: Chemical Rubber Co.,1969,33.

Chlorquinaldol Safety Profile

Poison by ingestion. When heated to decomposition it emits very toxic fumes of Cl⁻ and NO_x.
Hazard Codes Xn,T
Risk Statements 22-36/37/38-23/24/25
Safety Statements 26-36-36/37/39-45
RIDADR UN 2811 6.1/PG 3
WGK Germany 3
RTECS VC5600000

Product Name

5,7-Dichloro-8-hydroxyquinaldine

Synthetic route

Chlorquinaldol Chemical Properties

Chlorquinaldol Toxicity Data With Reference

Chlorquinaldol Safety Profile

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