• Name

  Cilnidipine

• EINECS 634-350-6
• CAS No. 132203-70-4
• Article Data4
• CAS DataBase
• Density 1.24 g/cm³
• Solubility
• Melting Point 97-99 °C
• Formula C₂₇H₂₈N₂O₇
• Boiling Point 652.6 °C at 760 mmHg
• Molecular Weight 492.529
• Flash Point 348.5 °C
• Transport Information
• Appearance yellow crystalline solid
• Safety 26-39
• Risk Codes 41
• Molecular Structure
• Hazard Symbols Xi
• Synonyms Cinalong;2-methoxyethyl cinnamyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate;Atelec;Cilnidipine (JAN);3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-, 2-methoxyethyl 3-phenyl-2-propenyl ester, (E)-(+-)-;Clinidipine (+-)-;(+-)-(E)-Cinnamyl 2-methoxyethyl 1,4-dihydro-2,6-dimethyl-4-(m-nitrophenyl)-3,5-pyridinedicarboxylate;Siscard;Atelec (TN);FRC 8653;Choriogonadotropin [alpha-subunit];
• PSA 119.68000
• LogP 5.12780

Synthetic route

3-amino-2-butenoic acid cinnamyl ester

39562-22-6

(E/Z)-2-methoxyethyl 2-(3-nitrobenzylidene)-acetoacetate

132203-70-4

cilnidipine

Conditions

Conditions	Yield
Stage #1: 3-amino-2-butenoic acid cinnamyl ester; (E/Z)-2-methoxyethyl 2-(3-nitrobenzylidene)-acetoacetate In ethanol for 1h; Reflux; Stage #2: With hydrogenchloride In ethanol; water for 1h; Solvent; Reagent/catalyst; Reflux;	91.5%
In ethanol for 22h; Reflux; Large scale;

3-amino-2-butenoic acid cinnamyl ester

C14H17NO6

132203-70-4

cilnidipine

Conditions

Conditions	Yield
In ethanol at 50℃; Solvent; Temperature;	91.4%

132203-70-4

cilnidipine

3-(2-methoxyethyl) 5-[(2E)-3-phenyl-2-propen-1-yl] 2,6-dimethyl-4-(3-nitrophenyl)pyridine-3,5-dicarboxylate

Conditions

Conditions	Yield
With 2,3-dicyano-5,6-dichloro-p-benzoquinone In dichloromethane at 20℃; for 2h;	89%
With 1,10-Phenanthroline; cerium(IV) sulphate; sulfuric acid In acetic acid

132203-70-4

cilnidipine

3-(2-methoxyethyl) 5-[(2E)-3-phenyl-2-propen-1-yl] 4-(3-aminophenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate

Conditions

Conditions	Yield
With iron; acetic acid at 100℃; for 0.25h;	78%

128446-35-5

heptakis-(2,3,6-tris-(2-hydroxypropyl))-β-cyclodextrin

132203-70-4

cilnidipine

C105H196O56*C27H28N2O7

Conditions

Conditions	Yield
In water at 20℃; for 24h;

Cilnidipine Chemical Properties

Cilnidipine Uses

Cilnidipine Toxicity Data With Reference