IUPAC Name: 6-[(1E,3E,5E,7E)-8-[(2S,3R,4R,5R)-3,4-Dihydroxy-2,4,5-trimethyloxolan-2-yl]-7-methylocta-1,3,5,7-tetraenyl]-4-methoxy-5-methylpyran-2-one
Synonyms of Citreoviridin (CAS NO.25425-12-1) : 2H-Pyran-2-one, 4-methoxy-5-methyl-6-(7-methyl-8-(tetrahydro-3,4-dihydroxy-2,4,5-trimethyl-2-furanyl)-1,3,5,7-octatetraenyl)- ; 4-Methoxy-5-methyl-6-(7-methyl-8-(tetrahydro-3,4-dihydroxy-2,4,5-trimethyl-2-furyl)-1,3,5,7-octatetraenyl)-2H-pyran-2-one ; Citreoviridin A
CAS NO:25425-12-1
Molecular Formula:C23H30O6
Molecular Weight :402.4807
Molecular Structure :
Index of Refraction: 1.569
Surface Tension: 47.4 dyne/cm
Density: 1.18 g/cm3
Flash Point: 197.7 °C
Enthalpy of Vaporization: 100.35 kJ/mol
Boiling Point: 585.1 °C at 760 mmHg
Vapour Pressure: 3.97E-16 mmHg at 25°C
Appearance:Orange-yellow powder
Solubility:Citreoviridin is soluble in benzene, ethanol, chloroform, ether, dichloromethane.
Water solubility: Citreoviridin (CAS NO.25425-12-1) is hardly soluble in water (enough to give it yellow color) and hexane
As other Aurovertin group members, Citreoviridin binds to and inhibit mitochondrial ATPase, thereby uncoupling oxidative phosphorylation. Citreoviridin (CAS NO.25425-12-1) are used as biochemical tools.
Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
---|---|---|---|---|---|
mouse | LD50 | intraperitoneal | 7200ug/kg (7.2mg/kg) | PERIPHERAL NERVE AND SENSATION: FLACCID PARALYSIS WITHOUT ANESTHESIA (USUALLY NEUROMUSCULAR BLOCKAGE) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES | Japanese Journal of Experimental Medicine. Vol. 42, Pg. 91, 1972. |
mouse | LD50 | oral | 29mg/kg (29mg/kg) | PERIPHERAL NERVE AND SENSATION: FLACCID PARALYSIS WITHOUT ANESTHESIA (USUALLY NEUROMUSCULAR BLOCKAGE) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES | Japanese Journal of Experimental Medicine. Vol. 42, Pg. 91, 1972. |
mouse | LD50 | subcutaneous | 9600ug/kg (9.6mg/kg) | BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY) LUNGS, THORAX, OR RESPIRATION: DYSPNEA | Research Communications in Chemical Pathology and Pharmacology. Vol. 59, Pg. 31, 1988. |
rabbit | LD50 | intraperitoneal | > 40mg/kg (40mg/kg) | Research Communications in Chemical Pathology and Pharmacology. Vol. 59, Pg. 31, 1988. | |
rabbit | LD50 | intravenous | 5mg/kg (5mg/kg) | Research Communications in Chemical Pathology and Pharmacology. Vol. 59, Pg. 31, 1988. | |
rat | LD50 | subcutaneous | 3600ug/kg (3.6mg/kg) | PERIPHERAL NERVE AND SENSATION: FLACCID PARALYSIS WITHOUT ANESTHESIA (USUALLY NEUROMUSCULAR BLOCKAGE) LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES | Japanese Journal of Experimental Medicine. Vol. 42, Pg. 91, 1972. |
rat | LDLo | intraperitoneal | 4100ug/kg (4.1mg/kg) | Japanese Journal of Experimental Medicine. Vol. 42, Pg. 91, 1972. | |
rat | LDLo | oral | 8mg/kg (8mg/kg) | Japanese Journal of Experimental Medicine. Vol. 42, Pg. 91, 1972. |
EPA Genetic Toxicology Program.
Poison by ingestion, subcutaneous, and intraperitoneal routes. When Citreoviridin (CAS NO.25425-12-1) is heated to decomposition it emits acrid smoke and irritating fumes.
RIDADR 3172
HazardClass 6.1(a)
PackingGroup II
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