-
Name
Clobetasone butyrate
- EINECS 246-635-9
- CAS No. 25122-57-0
- Article Data3
- CAS DataBase
- Density 1.26 g/cm3
- Solubility
- Melting Point 90-100°
- Formula C26H32ClFO5
- Boiling Point 573.3 °C at 760 mmHg
- Molecular Weight 478.988
- Flash Point 181.1 °C
- Transport Information
- Appearance
- Safety 22-36
- Risk Codes 40
-
Molecular Structure
-
Hazard Symbols
Xn
- Synonyms Pregna-1,4-diene-3,11,20-trione,21-chloro-9-fluoro-17-hydroxy-16b-methyl-, butyrate (8CI);Butyric acid, ester with21-chloro-9-fluoro-17-hydroxy-16b-methylpregna-1,4-diene-3,11,20-trione (8CI);CCl 5537;Clobetasone17-butyrate;Emovate;Eumovate;GR 2/1214;Kindavate;Molivate;SN 203;
- PSA 77.51000
- LogP 4.70140
Clobetasone butyrate Chemical Properties
IUPAC Name : [(8S,9R,10S,13S,14S,16S,17R)-17-(2-chloroacetyl)-9-fluoro-10,13,16-trimethyl-3,11-dioxo-7,8,12,14,15,16-hexahydro-6H-cyclopenta[a]phenanthren-17-yl] butano (25122-57-0)
CAS: 25122-57-0
Synonyms: 11,20-Trione,21-chloro-9-fluoro-17-hydroxy-16-beta-methyl-pregna-4-diene-3 N ;21-Chloro-9-fluoro-17-hydroxy-16-beta-methylpregna-1,4-diene,3,11,20-trione ; Eumovate ; Molivate;Pregna-1,4-diene-3,11,20-trione,21-chloro-9-fluoro-16-methyl-17-(1-oxobutoxy ; Sn203 ; 21-chloro-9-fluoro-17-hydroxy-16beta-methylpregna-1,4-diene-3,11,20-trione 17-butyrate
Molecular Formula :C26H32ClFO5
Molecular Weight :478.99
EINECS: 246-635-9
MS:
Product Categories: Organics
Mol File: 25122-57-0.mol
Surface Tension: 47 dyne/cm
Density: 1.26 g/cm3
Flash Point: 181.1 °C
Enthalpy of Vaporization: 85.92 kJ/mol
Boiling Point: 573.3 °C at 760 mmHg
Vapour Pressure: 3.78E-13 mmHg at 25°C
Stability: Stable. Combustible. Incompatible with strong oxidizing agents.
Clobetasone butyrate Uses
1. Clobetasone butyrate (25122-57-0) is good for the treatment of congenital atopic dermatitis, face, neck, axilla, perineal eczema and other diseases.
2.Apply to affected area with ointment, 1, 1 ~ 3 times.
3. Clobetasone butyrate (25122-57-0) can cause local irritation, itching, acne, miliaria, white ringworm, etc. should be promptly disabled. 2. Large or long-term large-scale applications, there may be glucocorticoid side effects.
Clobetasone butyrate Toxicity Data With Reference
| Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
| mouse | LD50 | intraperitoneal | 500mg/kg (500mg/kg) | | Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 14, Pg. 838, 1983. |
| mouse | LD50 | oral | > 6gm/kg (6000mg/kg) | behavioral: somnolence (general depressed activity) | Yakkyoku. Pharmacy. Vol. 35, Pg. 1473, 1984. |
| mouse | LD50 | subcutaneous | > 3600mg/kg (3600mg/kg) | behavioral: somnolence (general depressed activity) | Yakkyoku. Pharmacy. Vol. 35, Pg. 1473, 1984. |
| rat | LD50 | intraperitoneal | 1510mg/kg (1510mg/kg) | endocrine: other changes | Journal of Toxicological Sciences. Vol. 5, Pg. 45, 1980. |
| rat | LD50 | oral | > 6gm/kg (6000mg/kg) | behavioral: somnolence (general depressed activity) | Yakkyoku. Pharmacy. Vol. 35, Pg. 1473, 1984. |
| rat | LD50 | subcutaneous | > 2600mg/kg (2600mg/kg) | behavioral: somnolence (general depressed activity) | Yakkyoku. Pharmacy. Vol. 35, Pg. 1473, 1984. |
Clobetasone butyrate Safety Profile
Hazard Codes: Xn .gif){kind=small}
Risk Statements: 40
40: Limited evidence of a carcinogenic effect
Safety Statements: 22-36
22: Do not breathe dust
36: Clobetasone butyrate (25122-57-0) used,please wear suitable protective clothing .
RTECS : TU4154083
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