Product Name

Clobutinol Chemical Properties

IUPAC Name: 1-(4-chlorophenyl)-4-(dimethylamino)-2,3-dimethylbutan-2-ol
Synonyms of Clobutinol (CAS NO.14860-49-2) : 1-(4-Chlorophenyl)-4-(dimethylamino)-2,3-dimethylbutan-2-ol  ; 1-p-Chlorophenyl-2,3-dimethyl-4-dimethylamino-2-butanol  ; 4-Chloro-a-[2-(dimethylamino)-1-methylethyl]-a-methylbenzeneethanol ; Biotertussin
CAS NO:14860-49-2
Molecular Formula:C14H22ClNO
Molecular Weight :255.7836
Molecular Structure :
EINECS: 238-926-4
Index of Refraction: 1.53
Surface Tension: 38.3 dyne/cm
Density: 1.072 g/cm3
Flash Point: 169.6 °C
Enthalpy of Vaporization: 63.54 kJ/mol
Boiling Point: 356.8 °C at 760 mmHg
Vapour Pressure: 1.04E-05 mmHg at 25°C

Clobutinol Uses

 Clobutinol (CAS NO.14860-49-2) is a cough suppressant.

Clobutinol Toxicity Data With Reference

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
dog LD50 intravenous 45300ug/kg (45.3mg/kg)   Oyo Yakuri. Pharmacometrics. Vol. 8, Pg. 1067, 1974.
mouse LD50 intraperitoneal 128mg/kg (128mg/kg)   Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 6, Pg. 119, 1975.
mouse LD50 intravenous 53mg/kg (53mg/kg)   Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 6, Pg. 119, 1975.
mouse LD50 oral 334mg/kg (334mg/kg)   Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 6, Pg. 119, 1975.
mouse LD50 subcutaneous 262mg/kg (262mg/kg)   Oyo Yakuri. Pharmacometrics. Vol. 8, Pg. 1067, 1974.
rat LD50 intraperitoneal 165mg/kg (165mg/kg)   Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 6, Pg. 119, 1975.
rat LD50 intravenous 63mg/kg (63mg/kg)   Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 6, Pg. 119, 1975.
rat LD50 oral 802mg/kg (802mg/kg)   Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 6, Pg. 119, 1975.
rat LD50 subcutaneous 775mg/kg (775mg/kg)   Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 6, Pg. 119, 1975.

Clobutinol Safety Profile

Poison by ingestion, subcutaneous, intravenous, and intraperitoneal routes. When heated to decomposition it emits very toxic fumes of Cl− and NOx. See also ALCOHOL, DENATURED; ALCOHOLS, C6-12; ALCOHOLS, C9-11; ALCOHOLS, C12-13, ETHOXYLATED; ALCOHOLS, C12-15, ETHOXYLATED; ALCOHOLS, C12-16, ETHOXYLATED; ALCOHOLS, C14-15, ETHOXYLATED; ALCOHOLS, C16-18, ETHOXYLATED; ALCOHOLS, C8-10, ETHOXYLATED PROPOXYLATED; ALCOHOLS, C12-15, ETHOXYLATED PROPOXYLATED; ALCOHOLS, N.O.S..

Clobutinol Specification

 Clobutinol (CAS NO.14860-49-2) was recently determined to cause cardiac arrhythmia in some patients.Recent studies have indicated that clobutinol has the potential to prolong the QT interval.Boehringer Ingelheim products containing clobutinol were withdrawn from sale in Germany, and the rest of the world, on August 31, 2007

Related Products

Hot Products

Post buying leads

About|Contact|Cas|Product Name|Molecular|Country|Encyclopedia

Message|New Cas|MSDS|Service|Advertisement|CAS DataBase|Article Data|Manufacturers | Chemical Catalog

©2008 LookChem.com,License: ICP

NO.:Zhejiang16009103

complaints:service@lookchem.com Desktop View