-
Name
colchiceine
- EINECS 207-512-5
- CAS No. 477-27-0
- Article Data24
- CAS DataBase
- Density 1.31g/cm3
- Solubility
- Melting Point 172-1740C
- Formula C21H23 N O6
- Boiling Point 731.5°Cat760mmHg
- Molecular Weight 385.417
- Flash Point 396.2°C
- Transport Information
- Appearance
- Safety A deadly human poison by ingestion. An experimental poison by intravenous, intraperitoneal and possibly other routes. Mutation data reported. When heated to decomposition it emits toxic fumes of NOx. See also COLCHICINE.
- Risk Codes
-
Molecular Structure
- Hazard Symbols
- Synonyms Acetamide,N-(5,6,7,9-tetrahydro-10-hydroxy-1,2,3-trimethoxy-9-oxobenzo[a]heptalen-7-yl)-,(S)-; Colchiceine (6CI,7CI,8CI); Benzo[a]heptalene, acetamide deriv.; NSC33411; O10-Demethylcolchicine
- PSA 94.09000
- LogP 2.95950
Colchiceine Chemical Properties
Product Name: Colchiceine (CAS NO.477-27-0)
Molecular Formula: C21H23NO6
Molecular Weight: 385.45g/mol
Mol File: 477-27-0.mol
Einecs: 207-512-5
Appearance: Off- White to Pale Yellow Solid
Boiling point: 731.5 °C at 760 mmHg
Flash Point: 396.2 °C
Density: 1.31 g/cm3
Surface Tension: 56.7 dyne/cm
Enthalpy of Vaporization: 112.07 kJ/mol
Vapour Pressure: 1.83E-22 mmHg at 25°C
XLogP3-AA: 1.2
H-Bond Donor: 2
H-Bond Acceptor: 6
Structure Descriptors of Colchiceine (CAS NO.477-27-0):
IUPAC Name: N-[(7S)-10-hydroxy-1,2,3-trimethoxy-9-oxo-6,7-dihydro-5H-benzo[a]heptalen-7-yl]acetamide
Canonical SMILES: CC(=O)NC1CCC2=CC(=C(C(=C2C3=CC=C(C(=O)C=C13)O)OC)OC)OC
Isomeric SMILES: CC(=O)N[C@H]1CCC2=CC(=C(C(=C2C3=CC=C(C(=O)C=C13)O)OC)OC)OC
InChI: InChI=1S/C21H23NO6/c1-11(23)22-15-7-5-12-9-18(26-2)20(27-3)21(28-4)19(12)13-6-8-16(24)17(25)10-14(13)15/h6,8-10,15H,5,7H2,1-4H3,(H,22,23)(H,24,25)/t15-/m0/s1
InChIKey: PRGILOMAMBLWNG-HNNXBMFYSA-N
Product Categories: Various Metabolites and Impurities; Intermediates & Fine Chemicals; Metabolites & Impurities; Pharmaceuticals
Colchiceine Toxicity Data With Reference
| Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
|---|---|---|---|---|---|
| human | LDLo | oral | 43ug/kg (0.043mg/kg) | Pesticide Chemicals Official Compendium, Association of the American Pesticide Control Officials, Inc., 1966. Vol. -, Pg. 250, 1966. | |
| man | LDLo | oral | 714mg/kg (714mg/kg) | LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION KIDNEY, URETER, AND BLADDER: RENAL FUNCTION TESTS DEPRESSED BLOOD: CHANGES IN BONE MARROW NOT INCLUDED ABOVE | Medical Journal of Australia. Vol. 158, Pg. 28, 1993. |
| mouse | LD50 | intraperitoneal | 84mg/kg (84mg/kg) | BLOOD: HEMORRHAGE | Cancer Vol. 3, Pg. 124, 1950. |
| mouse | LD50 | intravenous | 1mg/kg (1mg/kg) | Comptes Rendus Hebdomadaires des Seances, Academie des Sciences. Vol. 241, Pg. 1889, 1955. | |
| rat | LD50 | intravenous | 2500ug/kg (2.5mg/kg) | BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: MUSCLE WEAKNESS GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA" | Pharmacology and Toxicology. English translation of FATOAO. Vol. 20, Pg. 284, 1957. |
| rat | LDLo | subcutaneous | 75mg/kg (75mg/kg) | Helvetica Chimica Acta. Vol. 33, Pg. 1606, 1950. | |
| rat | LDLo | unreported | 30mg/kg (30mg/kg) | Cancer Vol. 3, Pg. 124, 1950. |
Colchiceine Safety Profile
A deadly human poison by ingestion. An experimental poison by intravenous, intraperitoneal and possibly other routes. Mutation data reported. When heated to decomposition it emits toxic fumes of NOx. See also COLCHICINE.
Colchiceine Specification
Colchiceine ,its CAS NO. is 477-27-0,the synonyms is 4-14-00-00943 (Beilstein Handbook Reference) ; 7-Acetamido-10-hydroxy-1,2,3-trimethoxy-6,7-dihydrobenzo(a)heptalen-9(5H)-one ; BRN 2824078 ; Benzo(a)heptalen-10(5H)-one, 7-acetamido-6,7-dihydro-9-hydroxy-1,2,3-trimethoxy- ; Benzo(a)heptalen-9(5H)-one, 7-acetamido-6,7-dihydro-10-hydroxy-1,2,3-trimethoxy- ; EINECS 207-512-5 ; N-Acetyl trimethylcolchicinic acid ; NSC 123396 ; NSC 33411 ; O(sup 10)-Demethylcolchicine ; O10-Demethylcolchicine ; Acetamide, N-(5,6,7,9-tetrahydro-10-hydroxy-1,2,3-trimethoxy-9-oxobenzo(a)heptalen-7-yl)-, (S)- (9CI) .
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