• Name

  Cuscohygrine

• EINECS
• CAS No. 454-14-8
• Density 0.989 g/cm³
• Solubility soluble in water
• Melting Point
• Formula C₁₃H₂₄N₂O
• Boiling Point 312.4 °C at 760 mmHg
• Molecular Weight 224.346
• Flash Point 118 °C
• Transport Information
• Appearance
• Safety
• Risk Codes
• Molecular Structure
• Hazard Symbols
• Synonyms 2-Propanone,1,3-bis(1-methyl-2-pyrrolidinyl)-, (R*,S*)-;Cuscohygrine (6CI,7CI,8CI);Bellaradin;Bellaradine;Cuscohygrine, meso-;Cuskhygrin;Cuskhygrine;meso-Cuscohygrine;
• PSA 23.55000
• LogP 1.39990

Synthetic route

872-50-4

1-methyl-pyrrolidin-2-one

542-05-2

acetonedicarboxylic acid

454-14-8

cuscohygrine

Conditions

Conditions	Yield
With lithium aluminium tetrahydride anschliessende Decarboxylierung;

542-05-2

acetonedicarboxylic acid

7729-27-3

4-methylamino-butyraldehyde

454-14-8

cuscohygrine

Conditions

Conditions	Yield
With aqueous solution of pH 7 Erhitzen des Reaktionsprodukts unter vermindertem Druck;

857419-87-5

1,3-bis-(1-methyl-pyrrol-2-yl)-acetone

454-14-8

cuscohygrine

Conditions

Conditions	Yield
With palladium; acetic acid Hydrogenation;
With acetic acid; platinum Hydrogenation;

1066-30-4

chromium(lll) acetate

80408-55-5, 80408-56-6

dihydrocuscohygrine

454-14-8

cuscohygrine

Conditions

Conditions	Yield
isomer(ic) II;
isomer(ic) I;

872-50-4

1-methyl-pyrrolidin-2-one

542-05-2

acetonedicarboxylic acid

60-29-7

diethyl ether

lithium alanate

lithium alanate

A

454-14-8

cuscohygrine

B

(+-)-hygrine

(+-)-hygrine

Conditions

Conditions	Yield
in gepufferter wss. Loesung;

...Expand

454-14-8

cuscohygrine

74-88-4

methyl iodide

59884-19-4, 62209-22-7

1,1,1',1'-tetramethyl-2,2'-(2-oxo-propanediyl)-bis-pyrrolidinium; diiodide

Conditions

Conditions	Yield
With ethanol im Druckgefaess;

454-14-8

cuscohygrine

45771-52-6

(+/-)-hygrine

Conditions

Conditions	Yield
With hydrogenchloride at 180℃;
With potassium hydroxide; diethyl ether laengeres Stehen;
With potassium hydroxide 8-stdg. Kochen;

454-14-8

cuscohygrine

5370-14-9

(1-methyl-pyrrolidin-2-yl)-acetic acid ethyl ester

Conditions

Conditions	Yield
With nitrogen oxides; sodium ethanolate at 10 - 15℃;

454-14-8

cuscohygrine

A

1120-21-4

n-Undecane

B

23708-56-7

6-undecanol

Conditions

Conditions	Yield
With ethanol; sodium erschoepfende Methylierung des Reaktionsgemisches und folgende Hydrierung mit Wasserstoff und kolloidalem Platin in 50 prozentiger Essigsaeure;

454-14-8

cuscohygrine

1,3-bis-(1-methyl-pyrrolidin-2-yl)-acetone-hydrazone

Conditions

Conditions	Yield
With ethanol; hydrazine hydrate

454-14-8

cuscohygrine

68078-09-1

N-methylproline

Conditions

Conditions	Yield
With chromium(III) oxide; sulfuric acid

454-14-8

cuscohygrine

A

80408-55-5, 80408-56-6

dihydrocuscohygrine

B

α-dihydrocuscohygrine

α-dihydrocuscohygrine

Conditions

Conditions	Yield
With sodium amalgam; water isomer(ic) II;
With ethanol; sodium at 80℃; Trennung ueber das Pikrat; isomer(ic) II;

454-14-8

cuscohygrine

A

80408-55-5, 80408-56-6

dihydrocuscohygrine

B

β-dihydrocuscohygrine

β-dihydrocuscohygrine

Conditions

Conditions	Yield
With sodium amalgam; water isomer(ic) I;
With ethanol; sodium at 80℃; Trennung von der β-Form ueber das Pikrat; isomer(ic) I;

454-14-8

cuscohygrine

A

(1-methyl-pyrrolidin-2-yl)-acetone-hydrazone

B

cuscohygrine-hydrazone

cuscohygrine-hydrazone

Conditions

Conditions	Yield
With ethanol; hydrazine hydrate

454-14-8

cuscohygrine

5626-43-7, 52484-80-7

(RS)-1-methylpyrrolidine-2-acetic acid

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: nitrogen oxides; sodium ethylate / 10 - 15 °C 2: aq. barium hydroxide solution View Scheme

454-14-8

cuscohygrine

2-ethoxycarbonylmethyl-1,1-dimethyl-pyrrolidinium; iodide

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: nitrogen oxides; sodium ethylate / 10 - 15 °C 2: alcohol View Scheme

Cuscohygrine Specification