Cyclopenthiazide supplier | CasNO.742-20-1

Name
Cyclopenthiazide
EINECS 212-012-5
CAS No. 742-20-1
Density 1.471 g/cm³
Solubility soluble in alcohol, ether, acetone, chloroform-soluble
Melting Point 238-242ºC
Formula C13H18 Cl N3 O4 S2
Boiling Point 605.6 °C at 760 mmHg
Molecular Weight 379.889
Flash Point 320.1 °C
Transport Information
Appearance crystals
Safety Poison by intravenous route. An antihypertensive agent. When heated to decomposition it emits very toxic fumes of SO_x, NO_x, and Cl⁻.
Risk Codes
Molecular Structure
Hazard Symbols
Synonyms 6-Chloro-3-(cyclopentylmethyl)-3,4-dihydro-2H-1,2,4-benzothiadiazine-7-sulfonamide1,1-dioxide;6-Chloro-3-(cyclopentylmethyl)-3,4-dihydro-7-sulfamyl-2H-1,2,4-benzothiadiazine1,1-dioxide;6-Chloro-3-cyclopentylmethyl-7-sulfamoyl-3,4-dihydro-1,2,4-benzothiadiazine1,1-dioxide; Benesal; Ciba 8341-Su; Cyclomethiazide; Cyclometiazid;Cyclopenthiazide; Cyclopentiazid; NSC 107679; Navidreks; Navidrex; Navidrix;Salimed; Salimid; Salurilo-C; Su 8341; Tsiklometiazid; Ultra-Minzil
PSA 135.12000
LogP 4.92630

Cyclopenthiazide Chemical Properties

Molecular Formula: C₁₃H₁₈ClN₃O₄S₂
Molar mass: 379.88 g/mol
EINECS: 212-012-5
Density: 1.471 g/cm³
Flash Point: 320.1 °C
Index of Refraction: 1.6
Boiling Point: 605.6 °C at 760 mmHg
Vapour Pressure: 1.29E-14 mmHg at 25 °C
Appearance: White powder, odorless, almost tasteless
Solubility: Soluble in Ethanol , Ethyl ether , Acetone ; slightly soluble in Chloroform ; insoluble in water
Product categories of Cyclopenthiazide (CAS NO.742-20-1): Active Pharmaceutical Ingredients
Structure of Cyclopenthiazide (CAS NO.742-20-1):

XLogP3-AA: 1.3
H-Bond Donor: 3
H-Bond Acceptor: 7
IUPAC Name: 6-Chloro-3-(cyclopentylmethyl)-1,1-dioxo-3,4-dihydro-2H-benzo[e][1,2,
4]thiadiazine-7-sulfonamide
Canonical SMILES: C1CCC(C1)CC2NC3=CC(=C(C=C3S(=O)(=O)N2)S(=O)(=O)N)Cl
InChI: InChI=1S/C13H18ClN3O4S2/c14-9-6-10-12(7-11(9)22(15,18)19)23(20,
21)17-13(16-10)5-8-3-1-2-4-8/h6-8,13,16-17H,1-5H2,(H2,15,18,19)
InChIKey: BKYKPTRYDKTTJY-UHFFFAOYSA-N

Cyclopenthiazide Uses

Cyclopenthiazide (CAS NO.742-20-1) has been used for the treatment of edema and hypertension.

Cyclopenthiazide Production

Cyclopenthiazide (CAS NO.742-20-1) has been derived the cyclization of Acetaldehyde and 4,6-Cyclopentyl - 2-sulfonamide -3 - chloroaniline .

Cyclopenthiazide Toxicity Data With Reference

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Source
mouse	LD50	intravenous	232mg/kg (232mg/kg)	Archives Internationales de Pharmacodynamie et de Therapie. Vol. 131, Pg. 325, 1961.
mouse	LD50	oral	> 1gm/kg (1000mg/kg)	Drugs in Japan Vol. 6, Pg. 314, 1982.
rat	LD50	intravenous	142mg/kg (142mg/kg)	Archives Internationales de Pharmacodynamie et de Therapie. Vol. 131, Pg. 325, 1961.
rat	LD50	oral	1gm/kg (1000mg/kg)	Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 21, Pg. 775, 1979.

Cyclopenthiazide Safety Profile

Poison by intravenous route. An antihypertensive agent. When heated to decomposition it emits very toxic fumes of SO_x, NO_x, and Cl⁻.

Cyclopenthiazide Specification

Cyclopenthiazide ,its cas register number is 742-20-1. It also can be called Tsiklometiazid ; Benesal ; 2H-1,2,4-Benzothiadiazine-7-sulfonamide, 6-chloro-3-(cyclopentylmethyl)-3,4-dihydro-, 1,1-dioxide ; 3-Cyclopentylmethyl-6-chloro-7-sulfamyl-3,4-dihydro-1,2,4-benzothiadiazine 1,1-Dioxide ; 6-Chloro-3-cyclopentylmethyl-3,4-dihydro-7-sulfamoyl-2H-1,2,4-benzothiadiazine 1,1-Dioxide and 6-Chloro-3-(cyclopentylmethyl)-1,1-dioxo-3,4-dihydro-2H-benzo[e][1,2,4]thiadiazine-7-sulfonamide .

Product Name

Cyclopenthiazide