Cytochalasin B (CAS No.:14930-96-2) is a cell-permeable mycotoxin. It inhibits cytoplasmic division by blocking the formation of contractile microfilaments. It inhibits cell movement and induces nuclear extrusion. Cytochalasin B shortens actin filaments by blocking monomer addition at the fast-growing end of polymers. Cytochalasin B inhibits glucose transport and platelet aggregation. It blocks adenosine-induced apoptotic body formation without affecting activation of endogenous ADP-ribosylation in leukemia HL-60 cells. It is also used in cloning through nuclear transfer. Here enucleated recipient cells are treated with Hoechst stain containing cytochalsin B. Cytochalasin B makes the walls of the oocytes smoother and makes it easy for micro-manipulation so that the zona pellucida is not so rigid and can be easily pierced by the micro-needles.
Chemical Name: Cytochalasin B
CAS No.: 14930-96-2
EINECS: 239-000-2
RTECS: RO0205000
Molecular Formula: C29H37NO5
Molecular Weight: 479.61 g/mol
Melting Point: 218-223 °C
Density: 1.2 g/cm3
Flash Point: 401.7 °C
Boiling Point: 740.6 °C at 760 mmHg
Storage temp.: -20°C
Following is the structure of Cytochalasin B (CAS No.:14930-96-2):
1. | dni-hmn:oth 1 mg/L | CNREA8 Cancer Research. 45 (1985),311. | ||
2. | dni-hmn:hla 1 µmol/L | MUREAV Mutation Research. 92 (1982),427. | ||
3. | cyt-hmn:fbr 1 mg/L | JCLBA3 Journal of Cell Biology. 89 (1981),194. | ||
4. | cyt-hmn:oth 1 mg/L | JNCIAM Journal of the National Cancer Institute. 52 (1974),653. | ||
5. | cyt-mus:mmr 1 mg/L | ITCSAF In Vitro. 19 (1983),58. | ||
6. | ipr-ham TDLo:5 mg/kg (female 8D post):TER | TJADAB Teratology, A Journal of Abnormal Development. 22 (1980),59. | ||
7. | ipr-rat LD50:11 mg/kg | TOXIA6 Toxicon. 17 (1979),137. | ||
8. | ipr-mus LD50:30 mg/kg | FEPRA7 Federation Proceedings, Federation of American Societies for Experimental Biology. 38 (1979),438. |
EPA Genetic Toxicology Program.
Poison by intraperitoneal route. An experimental teratogen. Human mutation data reported. When heated to decomposition it emits toxic fumes of NOx.
Hazard Codes:
T+: Very toxic
T: Toxic
Risk Statements about Cytochalasin B (CAS No.:14930-96-2):
R63 Possible risk of harm to the unborn child.
R23/24/25: Toxic by inhalation, in contact with skin and if swallowed.
R26/27/28: Very toxic by inhalation, in contact with skin and if swallowed.
Safety Statements about Cytochalasin B (CAS No.:14930-96-2):
S28 After contact with skin, wash immediately with plenty of soap-suds.
S45 In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)
S36/37: Wear suitable protective clothing and gloves.
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