Product Name

  • Name

    D-Prolinamide

  • EINECS 613-116-7
  • CAS No. 62937-45-5
  • Article Data4
  • CAS DataBase
  • Density 1.106 g/cm3
  • Solubility Soluble in water.
  • Melting Point 95-97 °C
  • Formula C5H10N2O
  • Boiling Point 303.6 °C at 760 mmHg
  • Molecular Weight 114.147
  • Flash Point 137.4 °C
  • Transport Information
  • Appearance Crystalline
  • Safety 24/25
  • Risk Codes R34
  • Molecular Structure Molecular Structure of 62937-45-5 (D-Prolinamide)
  • Hazard Symbols C,T
  • Synonyms 2-Pyrrolidinecarboxamide,(R)-;(2R)-2-Carbamoylpyrrolidine;(R)-Prolinamide;(R)-Pyrrolidine-2-carboxamide;
  • PSA 55.12000
  • LogP 0.25280

Synthetic route

(2R)-2-carbamoyl-pyrrolidine-1-carboxylic acid benzyl ester
62937-47-7

(2R)-2-carbamoyl-pyrrolidine-1-carboxylic acid benzyl ester

(R)-prolinamide
62937-45-5

(R)-prolinamide

Conditions
ConditionsYield
With 10% palladium on carbon; hydrogen In methanol for 7h;100%
With hydrogen; palladium on activated charcoal In methanol for 9h; Ambient temperature;87.3%
D-proline ethyl ester hydrochloride

D-proline ethyl ester hydrochloride

(R)-prolinamide
62937-45-5

(R)-prolinamide

Conditions
ConditionsYield
With ammonia In ethanol at 0 - 20℃; Large scale;80%
Z-D-proline
6404-31-5

Z-D-proline

(R)-prolinamide
62937-45-5

(R)-prolinamide

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 1.) triethylamine, isobutyl chloroformate, 2.) ammonia / 1.) chloroform, 0 deg C, 2 h, 2.) chloroform, RT, overnight
2: 87.3 percent / hydrogen / 10percent palladium on carbon / methanol / 9 h / Ambient temperature
View Scheme
D-Prolin
344-25-2

D-Prolin

(R)-prolinamide
62937-45-5

(R)-prolinamide

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: sodium hydroxide / H2O / Ambient temperature
2: 1.) triethylamine, isobutyl chloroformate, 2.) ammonia / 1.) chloroform, 0 deg C, 2 h, 2.) chloroform, RT, overnight
3: 87.3 percent / hydrogen / 10percent palladium on carbon / methanol / 9 h / Ambient temperature
View Scheme
(R)-2-carbamoylpyrrolidine-1-carboxylic acid tert-butyl ester
70138-72-6

(R)-2-carbamoylpyrrolidine-1-carboxylic acid tert-butyl ester

(R)-prolinamide
62937-45-5

(R)-prolinamide

Conditions
ConditionsYield
Stage #1: (R)-2-carbamoylpyrrolidine-1-carboxylic acid tert-butyl ester With trifluoroacetic acid at 25℃;
Stage #2: With N-ethyl-N,N-diisopropylamine In dichloromethane at 25℃;
N-(4-(5-(difluoromethyl)-1,3,4-oxadiazol-2-yl)benzyl)-N-phenylethenesulfonamide

N-(4-(5-(difluoromethyl)-1,3,4-oxadiazol-2-yl)benzyl)-N-phenylethenesulfonamide

(R)-prolinamide
62937-45-5

(R)-prolinamide

(R)-1-(2-(N-(4-(5-(difluoromethyl)-1,3,4-oxadiazol-2-yl)benzyl)-N-phenylsulfamoyl)ethyl)pyrrolidine-2-carboxamide

(R)-1-(2-(N-(4-(5-(difluoromethyl)-1,3,4-oxadiazol-2-yl)benzyl)-N-phenylsulfamoyl)ethyl)pyrrolidine-2-carboxamide

Conditions
ConditionsYield
With N-ethyl-N,N-diisopropylamine In dichloromethane at 20℃; for 18h;92.9%
2-([1,1'-biphenyl]-4-yl)-4-methyl-5-(2-(methylsulfonyl)pyrimidin-4-yl)thiazole

2-([1,1'-biphenyl]-4-yl)-4-methyl-5-(2-(methylsulfonyl)pyrimidin-4-yl)thiazole

(R)-prolinamide
62937-45-5

(R)-prolinamide

(R)-1-{4-[2-((1,1'-biphenyl)-4-yl)-4-methylthiazol-5-yl]pyrimidin-2-yl}pyrrolidine-2-carboxamide

(R)-1-{4-[2-((1,1'-biphenyl)-4-yl)-4-methylthiazol-5-yl]pyrimidin-2-yl}pyrrolidine-2-carboxamide

Conditions
ConditionsYield
In N,N-dimethyl-formamide at 80℃;92%
9-bromo-10-(bromomethyl)-2,3,6,7-tetramethoxyphenanthrene
1215841-59-0

9-bromo-10-(bromomethyl)-2,3,6,7-tetramethoxyphenanthrene

(R)-prolinamide
62937-45-5

(R)-prolinamide

(R)-1-[(9-bromo-2,3,6,7-tetramethoxyphenanthren-10-yl)methyl]pyrrolidine-2-carboxamide
1394286-36-2

(R)-1-[(9-bromo-2,3,6,7-tetramethoxyphenanthren-10-yl)methyl]pyrrolidine-2-carboxamide

Conditions
ConditionsYield
With potassium carbonate In N,N-dimethyl-formamide for 8h; Reflux;91%
2-chloro-N-(1-(3,4,5-trimethoxyphenyl)-1H-imidazol-4-yl)thieno[3,2-d]pyrimidin-4-amine

2-chloro-N-(1-(3,4,5-trimethoxyphenyl)-1H-imidazol-4-yl)thieno[3,2-d]pyrimidin-4-amine

(R)-prolinamide
62937-45-5

(R)-prolinamide

(R)-1-(4-((1-(3,4,5-trimethoxyphenyl)-1H-imidazol-4-yl)amino)thieno[3,2-d]pyrimidin-2-yl)pyrrolidine-2-carboxamide hydrochloride

(R)-1-(4-((1-(3,4,5-trimethoxyphenyl)-1H-imidazol-4-yl)amino)thieno[3,2-d]pyrimidin-2-yl)pyrrolidine-2-carboxamide hydrochloride

Conditions
ConditionsYield
Stage #1: 2-chloro-N-(1-(3,4,5-trimethoxyphenyl)-1H-imidazol-4-yl)thieno[3,2-d]pyrimidin-4-amine; (R)-prolinamide With N-ethyl-N,N-diisopropylamine In 1-methyl-pyrrolidin-2-one at 130℃; for 18h; Microwave irradiation;
Stage #2: With hydrogenchloride In water; acetonitrile		90%
2-((4-(4,6-bismorpholine-1,3,5-triazin-2-yl)phenyl)amino)-1H-benzo[d]imidazole-6-carboxylic acid

2-((4-(4,6-bismorpholine-1,3,5-triazin-2-yl)phenyl)amino)-1H-benzo[d]imidazole-6-carboxylic acid

(R)-prolinamide
62937-45-5

(R)-prolinamide

(R)-1-(2-((4-(4,6-bismorpholin-1,3,5-triazin-2-yl)phenyl)amino)-1H-benzo[d]imidazole-6-carbonyl)pyrrolidine-2-carboxamide

(R)-1-(2-((4-(4,6-bismorpholin-1,3,5-triazin-2-yl)phenyl)amino)-1H-benzo[d]imidazole-6-carbonyl)pyrrolidine-2-carboxamide

Conditions
ConditionsYield
Stage #1: 2-((4-(4,6-bismorpholine-1,3,5-triazin-2-yl)phenyl)amino)-1H-benzo[d]imidazole-6-carboxylic acid With O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 20℃; for 0.666667h; Inert atmosphere;
Stage #2: (R)-prolinamide In N,N-dimethyl-formamide at 80℃; for 8h; Inert atmosphere;		88%
Ph(3-Cl)(5-OCHF2)-(R,S)CH(OH)C(O)OH
433938-41-1

Ph(3-Cl)(5-OCHF2)-(R,S)CH(OH)C(O)OH

(R)-prolinamide
62937-45-5

(R)-prolinamide

(R)-3-chloro-5-difluoro-methoxy-mandelic acid D-prolinamide salt

(R)-3-chloro-5-difluoro-methoxy-mandelic acid D-prolinamide salt

Conditions
ConditionsYield
In water; 4-methyl-2-pentanone at 20 - 100℃; for 22.5h; Purification / work up; Resolution of racemate;81.8%
In water; ethyl acetate at 0 - 75℃; for 3.16667 - 13.8333h; Product distribution / selectivity; Heating / reflux;n/a
In water; ethyl acetate at 72 - 75℃; for 0.166667 - 0.5h; Purification / work up; Resolution of racemate; Heating / reflux;n/a
2-chloro-7-isopropoxy-N-(1-(3,4,5-trimethoxyphenyl)-1H-imidazol-4-yl)quinazolin-4-amine

2-chloro-7-isopropoxy-N-(1-(3,4,5-trimethoxyphenyl)-1H-imidazol-4-yl)quinazolin-4-amine

(R)-prolinamide
62937-45-5

(R)-prolinamide

(R)-1-(7-isopropoxy-4-((1-(3,4,5-trimethoxyphenyl)-1H-imidazol-4-yl)amino)quinazolin-2-yl)pyrrolidine-2-carboxamide

(R)-1-(7-isopropoxy-4-((1-(3,4,5-trimethoxyphenyl)-1H-imidazol-4-yl)amino)quinazolin-2-yl)pyrrolidine-2-carboxamide

Conditions
ConditionsYield
With N-ethyl-N,N-diisopropylamine In 1-methyl-pyrrolidin-2-one at 150℃; for 5h; Microwave irradiation;81%
5-(4-chlorophenyl)-2-{[1-(4-chloropyridin-3-yl)-1H-1,2,4-triazol-3-yl]methyl}-4-[(2S)-3,3,3-trifluoro-2-hydroxypropyl]-2,4-dihydro-3H-1,2,4-triazol-3-one

5-(4-chlorophenyl)-2-{[1-(4-chloropyridin-3-yl)-1H-1,2,4-triazol-3-yl]methyl}-4-[(2S)-3,3,3-trifluoro-2-hydroxypropyl]-2,4-dihydro-3H-1,2,4-triazol-3-one

(R)-prolinamide
62937-45-5

(R)-prolinamide

1-{3-[3-({3-(4-chlorophenyl)-5-oxo-4-[(2S)-3,3,3-trifluoro-2-hydroxypropyl]-4,5-dihydro-1H-1,2,4-triazol-1-yl}methyl)-1H-1,2,4-triazol-1-yl]pyridin-4-yl}-D-prolinamide

1-{3-[3-({3-(4-chlorophenyl)-5-oxo-4-[(2S)-3,3,3-trifluoro-2-hydroxypropyl]-4,5-dihydro-1H-1,2,4-triazol-1-yl}methyl)-1H-1,2,4-triazol-1-yl]pyridin-4-yl}-D-prolinamide

Conditions
ConditionsYield
In ethanol Reflux;79%
5'-(cis-3-cycloheptyl-4-oxo-3,4,4a,5,8,8a-hexahydrophthalazin-1-yl)-2'-methoxy-[1,1'-biphenyl]-4-carboxylic acid

5'-(cis-3-cycloheptyl-4-oxo-3,4,4a,5,8,8a-hexahydrophthalazin-1-yl)-2'-methoxy-[1,1'-biphenyl]-4-carboxylic acid

(R)-prolinamide
62937-45-5

(R)-prolinamide

(R)-1-(5'-(cis-3-cycloheptyl-4-oxo-3,4,4a,5,8,8a-hexahydrophthalazin-1-yl)-2'-methoxy-[1,1'-biphenyl]-4-carbonyl)pyrrolidine-2-carboxamide

(R)-1-(5'-(cis-3-cycloheptyl-4-oxo-3,4,4a,5,8,8a-hexahydrophthalazin-1-yl)-2'-methoxy-[1,1'-biphenyl]-4-carbonyl)pyrrolidine-2-carboxamide

Conditions
ConditionsYield
With 1-hydroxy-7-aza-benzotriazole; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane at 20℃; for 3h; Inert atmosphere;78%
2-chloro-7-tosyl-N-(1-(3,4,5-trimethoxyphenyl)-1H-imidazol-4-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine

2-chloro-7-tosyl-N-(1-(3,4,5-trimethoxyphenyl)-1H-imidazol-4-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine

(R)-prolinamide
62937-45-5

(R)-prolinamide

(R)-1-(7-tosyl-4-((1-(3,4,5-trimethoxyphenyl)-1H-imidazol-4-yl)amino)-7H-pyrrolo[2,3-d]pyrimidin-2-yl)pyrrolidine-2-carboxamide

(R)-1-(7-tosyl-4-((1-(3,4,5-trimethoxyphenyl)-1H-imidazol-4-yl)amino)-7H-pyrrolo[2,3-d]pyrimidin-2-yl)pyrrolidine-2-carboxamide

Conditions
ConditionsYield
In isopropyl alcohol at 150℃; for 3h; Microwave irradiation;75%
(R)-prolinamide
62937-45-5

(R)-prolinamide

4-guanidinophenyl N-benzoylglycinate
288608-40-2

4-guanidinophenyl N-benzoylglycinate

Bz-Gly-D-Pro-NH2

Bz-Gly-D-Pro-NH2

Conditions
ConditionsYield
With clostripain; HEPES buffer; sodium chloride; calcium chloride at 25℃; pH=8.0;72.6%
5-(4-chlorophenyl)-2-{[1-(2-chloropyridin-3-yl)-1H-1,2,4-triazol-3-yl]methyl}-4-[(2S)-3,3,3-trifluoro-2-hydroxypropyl]-2,4-dihydro-3H-1,2,4-triazol-3-one

5-(4-chlorophenyl)-2-{[1-(2-chloropyridin-3-yl)-1H-1,2,4-triazol-3-yl]methyl}-4-[(2S)-3,3,3-trifluoro-2-hydroxypropyl]-2,4-dihydro-3H-1,2,4-triazol-3-one

(R)-prolinamide
62937-45-5

(R)-prolinamide

1-{3-[3-({3-(4-chlorophenyl)-5-oxo-4-[(2S)-3,3,3-trifluoro-2-hydroxypropyl]-4,5-dihydro-1H-1,2,4-triazol-1-yl}methyl)-1H-1,2,4-triazol-1-yl]pyridin-2-yl}-D-prolinamide

1-{3-[3-({3-(4-chlorophenyl)-5-oxo-4-[(2S)-3,3,3-trifluoro-2-hydroxypropyl]-4,5-dihydro-1H-1,2,4-triazol-1-yl}methyl)-1H-1,2,4-triazol-1-yl]pyridin-2-yl}-D-prolinamide

Conditions
ConditionsYield
In ethanol Reflux;70%
(R)-prolinamide
62937-45-5

(R)-prolinamide

allyl (5R,6S)-2-<<(methylsulfonyl)oxy>methyl>-6-<(R)-1-<(tert-butyldimethylsilyl)oxy>ethyl>penem-3-carboxylate
88585-79-9

allyl (5R,6S)-2-<<(methylsulfonyl)oxy>methyl>-6-<(R)-1-<(tert-butyldimethylsilyl)oxy>ethyl>penem-3-carboxylate

A

allyl (5R,6S)-2-<((2R)-1-prolinamido)methyl>-6-<(R)-1-<(tert-butyldimethylsilyl)oxy>ethyl>penem-3-carboxylate
166374-72-7

allyl (5R,6S)-2-<((2R)-1-prolinamido)methyl>-6-<(R)-1-<(tert-butyldimethylsilyl)oxy>ethyl>penem-3-carboxylate

B

2-[(S)-2-(tert-Butyl-dimethyl-silanyloxy)-1-((R)-2-carbamoyl-pyrrolidine-1-carbonyl)-propyl]-5-methyl-thiazole-4-carboxylic acid allyl ester

2-[(S)-2-(tert-Butyl-dimethyl-silanyloxy)-1-((R)-2-carbamoyl-pyrrolidine-1-carbonyl)-propyl]-5-methyl-thiazole-4-carboxylic acid allyl ester

Conditions
ConditionsYield
With triethylamine In dimethyl sulfoxide for 20h; Ambient temperature;A 66%
B n/a
...Expand
benzoylamino-acetic acid benzyl ester
19811-58-6

benzoylamino-acetic acid benzyl ester

(R)-prolinamide
62937-45-5

(R)-prolinamide

Bz-Gly-D-Pro-NH2

Bz-Gly-D-Pro-NH2

Conditions
ConditionsYield
With syn-benzaldehyde oxime; triethylamine; diothiothreitol In toluene at 35℃; immobilized papain;65%
(R)-prolinamide
62937-45-5

(R)-prolinamide

Bz-D-Ala-OGp

Bz-D-Ala-OGp

Bz-D-Ala-D-Pro-NH2

Bz-D-Ala-D-Pro-NH2

Conditions
ConditionsYield
With clostripain; HEPES buffer; sodium chloride; calcium chloride at 25℃; pH=8.0;60.7%
2-chloro-N-(1-(3,4,5-trimethoxyphenyl)-1H-imidazol-4-yl)-5,6,7,8-tetrahydroquinazolin-4-amine

2-chloro-N-(1-(3,4,5-trimethoxyphenyl)-1H-imidazol-4-yl)-5,6,7,8-tetrahydroquinazolin-4-amine

(R)-prolinamide
62937-45-5

(R)-prolinamide

(R)-1-(4-((1-(3,4,5-trimethoxyphenyl)-1H-imidazol-4-yl)amino)-5,6,7,8-tetrahydroquinazolin-2-yl)pyrrolidine-2-carboxamide hydrochloride

(R)-1-(4-((1-(3,4,5-trimethoxyphenyl)-1H-imidazol-4-yl)amino)-5,6,7,8-tetrahydroquinazolin-2-yl)pyrrolidine-2-carboxamide hydrochloride

Conditions
ConditionsYield
Stage #1: 2-chloro-N-(1-(3,4,5-trimethoxyphenyl)-1H-imidazol-4-yl)-5,6,7,8-tetrahydroquinazolin-4-amine; (R)-prolinamide In isopropyl alcohol at 150℃; for 3h; Microwave irradiation;
Stage #2: With hydrogenchloride In water; acetonitrile		60%
2-chloro-N-(1-(3,4,5-trimethoxyphenyl)-1H-imidazol-4-yl)quinazolin-4-amine

2-chloro-N-(1-(3,4,5-trimethoxyphenyl)-1H-imidazol-4-yl)quinazolin-4-amine

(R)-prolinamide
62937-45-5

(R)-prolinamide

(R)-1-(4-((1-(3,4,5-trimethoxyphenyl)-1H-imidazol-4-yl)amino)quinazolin-2-yl)pyrrolidine-2-carboxamide hydrochloride

(R)-1-(4-((1-(3,4,5-trimethoxyphenyl)-1H-imidazol-4-yl)amino)quinazolin-2-yl)pyrrolidine-2-carboxamide hydrochloride

Conditions
ConditionsYield
Stage #1: 2-chloro-N-(1-(3,4,5-trimethoxyphenyl)-1H-imidazol-4-yl)quinazolin-4-amine; (R)-prolinamide With N-ethyl-N,N-diisopropylamine In 1-methyl-pyrrolidin-2-one at 130℃; for 18h; Microwave irradiation;
Stage #2: With hydrogenchloride In water; acetonitrile		58%
2-[3-({3-(4-chlorophenyl)-5-oxo-4-[(2S)-3,3,3-trifluoro-2-hydroxypropyl]-4,5-dihydro-1H-1,2,4-triazol-1-yl}methyl)-1H-1,2,4-triazol-1-yl]benzoyl chloride

2-[3-({3-(4-chlorophenyl)-5-oxo-4-[(2S)-3,3,3-trifluoro-2-hydroxypropyl]-4,5-dihydro-1H-1,2,4-triazol-1-yl}methyl)-1H-1,2,4-triazol-1-yl]benzoyl chloride

(R)-prolinamide
62937-45-5

(R)-prolinamide

1-{2-[3-({3-(4-chlorophenyl)-5-oxo-4-[(2S)-3,3,3-trifluoro-2-hydroxypropyl]-4,5-dihydro-1H-1,2,4-triazol-1-yl}methyl)-1H-1,2,4-triazol-1-yl]benzoyl}-D-prolinamide

1-{2-[3-({3-(4-chlorophenyl)-5-oxo-4-[(2S)-3,3,3-trifluoro-2-hydroxypropyl]-4,5-dihydro-1H-1,2,4-triazol-1-yl}methyl)-1H-1,2,4-triazol-1-yl]benzoyl}-D-prolinamide

Conditions
ConditionsYield
With N-ethyl-N,N-diisopropylamine In tetrahydrofuran at 20℃; for 1h;57%
(R)-prolinamide
62937-45-5

(R)-prolinamide

(S)-1-nitrosopyrrolidine-2-carboxamide

(S)-1-nitrosopyrrolidine-2-carboxamide

Conditions
ConditionsYield
With tert.-butylhydroperoxide; nitromethane; potassium iodide In water at 80℃; for 6h;56%
5'-(cis-3-isopropyl-4-oxo-3,4,4a,5,8,8a-hexahydrophthalazin-1-yl)-2'-methoxy-[1,1'-biphenyl]-4-carboxylic acid

5'-(cis-3-isopropyl-4-oxo-3,4,4a,5,8,8a-hexahydrophthalazin-1-yl)-2'-methoxy-[1,1'-biphenyl]-4-carboxylic acid

(R)-prolinamide
62937-45-5

(R)-prolinamide

(R)-1-(5'-(cis-3-isopropyl-4-oxo-3,4,4a,5,8,8a-hexahydrophthalazin-1-yl)-2'-methoxy-[1,1'-biphenyl]-4-carbonyl)pyrrolidine-2-carboxamide

(R)-1-(5'-(cis-3-isopropyl-4-oxo-3,4,4a,5,8,8a-hexahydrophthalazin-1-yl)-2'-methoxy-[1,1'-biphenyl]-4-carbonyl)pyrrolidine-2-carboxamide

Conditions
ConditionsYield
With 1-hydroxy-7-aza-benzotriazole; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane at 20℃; for 3h; Inert atmosphere;56%
2-chloro-N-(1-(3,4,5-trimethoxyphenyl)-1H-imidazol-4-yl)thieno[2,3-d]pyrimidin-4-amine

2-chloro-N-(1-(3,4,5-trimethoxyphenyl)-1H-imidazol-4-yl)thieno[2,3-d]pyrimidin-4-amine

(R)-prolinamide
62937-45-5

(R)-prolinamide

(R)-1-(4-((1-(3,4,5-trimethoxyphenyl)-1H-imidazol-4-yl)amino)thieno[2,3-d]pyrimidin-2-yl)pyrrolidine-2-carboxamide hydrochloride

(R)-1-(4-((1-(3,4,5-trimethoxyphenyl)-1H-imidazol-4-yl)amino)thieno[2,3-d]pyrimidin-2-yl)pyrrolidine-2-carboxamide hydrochloride

Conditions
ConditionsYield
Stage #1: 2-chloro-N-(1-(3,4,5-trimethoxyphenyl)-1H-imidazol-4-yl)thieno[2,3-d]pyrimidin-4-amine; (R)-prolinamide With N-ethyl-N,N-diisopropylamine In 1-methyl-pyrrolidin-2-one at 130℃; for 18h; Microwave irradiation;
Stage #2: With hydrogenchloride In water; acetonitrile		56%
2-(2-(4-(tert-butyl)phenyl)-4-methylthiazol-5-yl)-5-(methylsulfonyl)-1,3,4-oxadiazole

2-(2-(4-(tert-butyl)phenyl)-4-methylthiazol-5-yl)-5-(methylsulfonyl)-1,3,4-oxadiazole

(R)-prolinamide
62937-45-5

(R)-prolinamide

(R)-1-{5-[2-(4-(tert-butyl)phenyl)-4-methylthiazol-5-yl]-1,3,4-oxadiazol-2-yl}pyrrolidine-2-carboxamide

(R)-1-{5-[2-(4-(tert-butyl)phenyl)-4-methylthiazol-5-yl]-1,3,4-oxadiazol-2-yl}pyrrolidine-2-carboxamide

Conditions
ConditionsYield
With potassium carbonate In N,N-dimethyl-formamide at 80℃;56%
2-chloro-N-(1-(3,4,5-trimethoxyphenyl)-1H-imidazol-4-yl)-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-amine

2-chloro-N-(1-(3,4,5-trimethoxyphenyl)-1H-imidazol-4-yl)-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-amine

(R)-prolinamide
62937-45-5

(R)-prolinamide

(R)-1-(4-((1-(3,4,5-trimethoxyphenyl)-1H-imidazol-4-yl)amino)-6,7-dihydro-5H-cyclopenta[d]pyrimidin-2-yl)pyrrolidine-2-carboxamide hydrochloride

(R)-1-(4-((1-(3,4,5-trimethoxyphenyl)-1H-imidazol-4-yl)amino)-6,7-dihydro-5H-cyclopenta[d]pyrimidin-2-yl)pyrrolidine-2-carboxamide hydrochloride

Conditions
ConditionsYield
Stage #1: 2-chloro-N-(1-(3,4,5-trimethoxyphenyl)-1H-imidazol-4-yl)-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-amine; (R)-prolinamide With N-ethyl-N,N-diisopropylamine In 1-methyl-pyrrolidin-2-one at 125℃; for 15h; Microwave irradiation;
Stage #2: With hydrogenchloride In water; acetonitrile		55%
(R)-prolinamide
62937-45-5

(R)-prolinamide

Bz-D-Leu-OGp

Bz-D-Leu-OGp

Bz-D-Leu-D-Pro-NH2

Bz-D-Leu-D-Pro-NH2

Conditions
ConditionsYield
With clostripain; HEPES buffer; sodium chloride; calcium chloride In N,N-dimethyl-formamide at 25℃; pH=8.0;46.2%
(R)-prolinamide
62937-45-5

(R)-prolinamide

(-)-(R)-2-aminomethylpyrrolidine
57734-57-3, 69500-64-7, 123654-27-3, 72300-69-7

(-)-(R)-2-aminomethylpyrrolidine

Conditions
ConditionsYield
With lithium aluminium tetrahydride In tetrahydrofuran for 33h; Heating;46.1%
Stage #1: (R)-prolinamide With lithium aluminium tetrahydride In tetrahydrofuran at 0℃; Reflux;
Stage #2: With water In tetrahydrofuran		30%
With lithium aluminium tetrahydride In tetrahydrofuran at 0℃; Reflux;
With lithium aluminium tetrahydride
With lithium aluminium tetrahydride In tetrahydrofuran at 0 - 75℃;
(R)-prolinamide
62937-45-5

(R)-prolinamide

Bz-D-Phe-OGp

Bz-D-Phe-OGp

Bz-D-Phe-D-Pro-NH2

Bz-D-Phe-D-Pro-NH2

Conditions
ConditionsYield
With clostripain; HEPES buffer; sodium chloride; calcium chloride In N,N-dimethyl-formamide at 25℃; pH=8.0;44%
3-{(S)-1-[4-(6-fluoro-pyridin-3-yl)-phenyl]-ethyl}-(S)-6-(2-hydroxy-2-methyl-propyl)-6-phenyl-[1,3]oxazinan-2-one
1352754-29-0

3-{(S)-1-[4-(6-fluoro-pyridin-3-yl)-phenyl]-ethyl}-(S)-6-(2-hydroxy-2-methyl-propyl)-6-phenyl-[1,3]oxazinan-2-one

(R)-prolinamide
62937-45-5

(R)-prolinamide

(R)-1-[5-(4-{(S)-1-[(S)-6-(2-hydroxy-2-methyl-propyl)-2-oxo-6-phenyl-[1,3]oxazinan-3-yl]-ethyl}-phenyl)-pyridin-2-yl]-pyrrolidine-2-carboxylic acid amide
1352753-90-2

(R)-1-[5-(4-{(S)-1-[(S)-6-(2-hydroxy-2-methyl-propyl)-2-oxo-6-phenyl-[1,3]oxazinan-3-yl]-ethyl}-phenyl)-pyridin-2-yl]-pyrrolidine-2-carboxylic acid amide

Conditions
ConditionsYield
With potassium carbonate In dimethyl sulfoxide at 100℃;43%

D-Prolinamide Chemical Properties

Molecular Structure of H-D-Pro-NH2 (CAS NO.62937-45-5):

Molecular Formula: C5H10N2O
Molecular Weight: 114.15
IUPAC Name: Dichloropalladium
CAS NO: 62937-45-5
Melting Point: 95-97°C 
Index of Refraction: 1.491
Molar Refractivity: 29.9 cm3
Molar Volume: 103.1 cm3
Surface Tension: 41.4 dyne/cm
Density: 1.106 g/cm3
Flash Point: 137.4 °C
Enthalpy of Vaporization: 54.39 kJ/mol
Boiling Point: 303.6 °C at 760 mmHg
Vapour Pressure of H-D-Pro-NH2 (CAS NO.62937-45-5): 0.000923 mmHg at 25°C
Classification Code: Amide ; Aminoacids derivatives ; Pyrrolidines ; Proline [Pro, P] ; Amino Acids and Derivatives
InChI: InChI=1/C5H10N2O/c6-5(8)4-2-1-3-7-4/h4,7H,1-3H2,(H2,6,8)/t4-/m1/s1
InChIKey: VLJNHYLEOZPXFW-SCSAIBSYBV
Std. InChI: InChI=1S/C5H10N2O/c6-5(8)4-2-1-3-7-4/h4,7H,1-3H2,(H2,6,8)/t4-/m1/s1
Std. InChIKey: VLJNHYLEOZPXFW-SCSAIBSYSA-N

D-Prolinamide Specification

   H-D-Pro-NH2 (CAS No.62937-45-5), it also can be called 2-Pyrrolidinecarboxamide, (2R)- ; D-Prolinamide ; (R)-Pyrrolidine-2-carboxylic acid amide ; (R)-Prolinamide  .

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