Product Name

  • Name

    FLURAZEPAM DIHYDROCHLORIDE

  • EINECS
  • CAS No. 1172-18-5
  • Density g/cm3
  • Solubility
  • Melting Point 190-220°
  • Formula C21H23 Cl F N3 O . 2 Cl H
  • Boiling Point 551.4°Cat760mmHg
  • Molecular Weight 460.806
  • Flash Point 287.2°C
  • Transport Information
  • Appearance
  • Safety Poison by intravenous and intraperitoneal routes. Moderately toxic by ingestion and subcutaneous routes. Habituating and possibly addictive. An hypnotic and sedative. When heated to decomposition it emits very toxic fumes of F−, NOx, and Cl−.
  • Risk Codes 22-33
  • Molecular Structure Molecular Structure of 1172-18-5 (FLURAZEPAM DIHYDROCHLORIDE)
  • Hazard Symbols
  • Synonyms 2H-1,4-Benzodiazepin-2-one,7-chloro-1-[2-(diethylamino)ethyl]-5-(2-fluorophenyl)-1,3-dihydro-,dihydrochloride (9CI); 2H-1,4-Benzodiazepin-2-one,7-chloro-1-[2-(diethylamino)ethyl]-5-(o-fluorophenyl)-1,3-dihydro-,dihydrochloride (7CI,8CI); 7-Chloro-1-(2-diethylaminoethyl)-5-(2-fluorophenyl)-1,3-dihydro-2H-1,4-benzodiazepin-2-onedihydrochloride;7-Chloro-1-[2-(diethylamino)ethyl]-5-(o-fluorophenyl)-1,3-dihydro-2H-1,4-benzodiazepin-2-onedihydrochloride; Benozil; Dalmadorm; Dalmane; Dalmate; Dormodor; Felson;Flurazepam dihydrochloride; Flurazepam hydrochloride; ID 480; Insumin; Lunipax;NSC 78559; Ro 5-6901; Somlan
  • PSA 35.91000
  • LogP 5.10950

DALMANE Chemical Properties

Product Name: Dalmane (CAS NO.1172-18-5)


Molecular Formula: C21H25Cl3FN3O
Molecular Weight: 460.8g/mol
Mol File: 1172-18-5.mol
Einecs: 214-630-0
Appearance: Odorless off-white to yellow crystalline powder
Boiling point: 551.4 °C at 760 mmHg
Storage Temperature: 2-8°C
Flash Point: 287.2 °C
Solubility: 45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: <6 mg/mL
Enthalpy of Vaporization: 83.17 kJ/mol
Vapour Pressure: 3.34E-12 mmHg at 25°C
XLogP3-AA:
H-Bond Donor: 2
H-Bond Acceptor: 4
Product Categories: Organics

DALMANE Toxicity Data With Reference

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intraperitoneal 186mg/kg (186mg/kg)   Yakkyoku. Pharmacy. Vol. 26, Pg. 741, 1975.
mouse LD50 intravenous 59100ug/kg (59.1mg/kg)   Yakkyoku. Pharmacy. Vol. 26, Pg. 741, 1975.
mouse LD50 oral 596mg/kg (596mg/kg)   Yakkyoku. Pharmacy. Vol. 26, Pg. 741, 1975.
mouse LD50 subcutaneous 440mg/kg (440mg/kg) BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)

BEHAVIORAL: ATAXIA

BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY)		 Oyo Yakuri. Pharmacometrics. Vol. 14, Pg. 637, 1977.
rabbit LD50 oral 568mg/kg (568mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION		 Archives Internationales de Pharmacodynamie et de Therapie. Vol. 178, Pg. 216, 1969.
rat LD50 intraperitoneal 152mg/kg (152mg/kg)   Yakkyoku. Pharmacy. Vol. 26, Pg. 741, 1975.
rat LD50 intravenous 38700ug/kg (38.7mg/kg)   Yakkyoku. Pharmacy. Vol. 26, Pg. 741, 1975.
rat LD50 oral 879mg/kg (879mg/kg)   Yakkyoku. Pharmacy. Vol. 26, Pg. 741, 1975.
rat LD50 subcutaneous 859mg/kg (859mg/kg)   Drugs in Japan Vol. 6, Pg. 706, 1982.

DALMANE Safety Profile

Poison by intravenous and intraperitoneal routes. Moderately toxic by ingestion and subcutaneous routes. Habituating and possibly addictive. An hypnotic and sedative. When heated to decomposition it emits very toxic fumes of F−, NOx, and Cl−.
Safety Information of Dalmane (CAS NO.1172-18-5):
Hazard Codes: Xn
Risk Statements: 22-33 
22:  Harmful if swallowed
33:  Danger of cumulative effects
Safety Statements: 1/2-22-36-36/37/39
1:  Keep locked up 
2:  Keep out of the reach of children
22:  Do not breathe dust
36:  Wear suitable protective clothing  
37:  Wear suitable gloves  
39:  Wear eye/face protection 

DALMANE Specification

 Dalmane ,its CAS NO. is 1172-18-5,the synonyms is 1,3-Dihydro-l)dihydrochloride ; 2H-1,4-benzodiazepin-2-one,7-chloro-1-(2-(diethylamino)ethyl)-5-(o-fluoropheny ; Benozil ; Dalmadorm ; Dalmadormhydrochloride ; Dormodor .

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