Product Name

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  • Name

    DL-Norephedrine hydrochloride

  • EINECS 205-826-7
  • CAS No. 154-41-6
  • Article Data9
  • CAS DataBase
  • Density 1.071g/cm3
  • Solubility >=10 g/100 mL at 21 C
  • Melting Point 194-196 °C(lit.)
  • Formula C9H13NO.HCl
  • Boiling Point 288.1 °C at 760 mmHg
  • Molecular Weight 187.669
  • Flash Point 128.1 °C
  • Transport Information UN 2811
  • Appearance white crystalline powder
  • Safety 22-36/37/39-45
  • Risk Codes 22
  • Molecular Structure Molecular Structure of 154-41-6 (DL-Norephedrine hydrochloride)
  • Hazard Symbols HarmfulXn
  • Synonyms Benzenemethanol, a-[(1R)-1-aminoethyl]-,hydrochloride, (aS)-rel-(9CI);Acutrim;Benzenemethanol, a-(1-aminoethyl)-, hydrochloride, (R*,S*)-;Dexatrim;Flurest;IP 58064;Mydriatin;NSC 23798;Norephedrine hydrochloride;Obestat;Permathene 16;Phenylpropanolaminehydrochloride;Propadrine hydrochloride;Thinz-Span;dl-Norephedrinehydrochloride;dl-Phenylpropanolamine hydrochloride;erythro-Norephedrinehydrochloride;
  • PSA 46.25000
  • LogP 2.56950

DL-Norephedrine hydrochloride Chemical Properties

The Molecular formula of PROPADRINE HYDROCHLORIDE(154-41-6):C9H14ClNO  
The Molecular Weight of PROPADRINE HYDROCHLORIDE(154-41-6):187.67 
The Molecular Structure of PROPADRINE HYDROCHLORIDE(154-41-6) is:
Melting point:194-196 °C(lit.)
Boiling point:288.1 °C at 760 mmHg
Flash point:128.1 °C   
Solubility in water:soluble
Merck:13,7391
Enthalpy of Vaporization:55.7 kJ/mol  
Vapour Pressure:0.0011 mmHg at 25°C
Appearance:odorless white to creamy-white crystalline powder. 
IUPAC Name:2-amino-1-phenylpropan-1-ol hydrochloride
Synonyms::[R*,S*]-[+/-]-ALPHA-[AMINOETHYL]BENZENEMETHANOL HYDROCHLORIDE;NOREPHEDRINE HCL;[+/-]-NOREPHEDRINE HYDROCHLORIDE;NOREPHEDRINE HYDROCHLORIDE;PHENYLPROPANOLAMINE HCL;(+/-)-PHENYLPROPANOLAMINE HYDROCHLORIDE;PHENYLPROPANOLAMINE HYDROCHLORIDE;(+/-)-NOREPHEDRINE HYDROCHLORIDE
Reactivity Profile:DL-Norephedrine hydrochloride is incompatible with strong oxidizing agents.

DL-Norephedrine hydrochloride Uses

This product is nasal decongestants, anorectics agent.

DL-Norephedrine hydrochloride Toxicity Data With Reference

1.   

orl-rat LD50:1490 mg/kg

   TXAPA9    Toxicology and Applied Pharmacology. 18 (1971),185.
2.   

ipr-rat LD50:160 mg/kg

   JPETAB    Journal of Pharmacology and Experimental Therapeutics. 86 (1946),284.
3.   

scu-rat LDLo:80 mg/kg

   JPETAB    Journal of Pharmacology and Experimental Therapeutics. 71 (1941),62.
4.   

orl-mus LD50:150 mg/kg

   THERAP    Therapie. 20 (1965),297.
5.   

ipr-mus LD50:428 mg/kg

   JPETAB    Journal of Pharmacology and Experimental Therapeutics. 92 (1948),207.
6.   

scu-mus LD50:600 mg/kg

   JPETAB    Journal of Pharmacology and Experimental Therapeutics. 86 (1946),280.
7.   

ivn-mus LDLo:275 mg/kg

   QJPPAL    Quarterly Journal of Pharmacy and Pharmacology. 9 (1936),203.
8.   

scu-rbt LD50:255 mg/kg

   JPETAB    Journal of Pharmacology and Experimental Therapeutics. 86 (1946),284.
9.   

ivn-rbt LD50:50 mg/kg

   JPETAB    Journal of Pharmacology and Experimental Therapeutics. 86 (1946),284.
10.   

ims-rbt LD50:320 mg/kg

   JPETAB    Journal of Pharmacology and Experimental Therapeutics. 86 (1946)

DL-Norephedrine hydrochloride Consensus Reports

Reported in EPA TSCA Inventory.

DL-Norephedrine hydrochloride Safety Profile

Poison by ingestion, subcutaneous, intravenous, intraperitoneal, and intramuscular routes. An experimental teratogen. When heated to decomposition it emits very toxic fumes of HCl and NOx. Used as a raw material in cold and diet tablets.
Hazard Codes:Xn
Xn:Harmful
Risk Statements
Harmful if swallowed.
Safety Statements
S22:Do not breathe dust .
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection .
S45:In case of accident or if you feel unwell, seek medical advice immediately (show label where possible) .
RIDADR:UN 2811
WGK Germany:3
RTECS:DN4200000
 

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