• Name

  derquantel

• EINECS
• CAS No. 187865-22-1
• Article Data1
• CAS DataBase
• Density 1.34
• Solubility
• Melting Point
• Formula C₂₈H₃₇N₃O₄
• Boiling Point 641.3±55.0 °C(Predicted)
• Molecular Weight 479.619
• Flash Point
• Transport Information
• Appearance
• Safety
• Risk Codes
• Molecular Structure
• Hazard Symbols
• Synonyms Spiro[4H,8H-[1,4]dioxepino[2,3-g]indole-8,7'(8'H)-[5H,6H-5a,9a](iminomethano)[1H]cyclopent[f]indolizin]-10'-one,2',3',8'a,9,9',10-hexahydro-1'-hydroxy-1',4,4,8',8',11'-hexamethyl-, [1'R-(1'a,5'ab,7'b,8'ab,9'ab)]-;2-Deoxoparaherquamide;2-Deoxoparaherquamide A;2-Desoxoparaherquamide A;Derquantel;PF 00520904;PNU 141962;
• PSA 74.27000
• LogP 3.28330

Synthetic route

187865-16-3

C28H35N3O4

187865-22-1

Derquantel

Conditions

Conditions	Yield
With sodium tetrahydroborate In methanol at 0℃;	80%

77392-58-6

Paraherquamide

187865-22-1

Derquantel

Conditions

Conditions	Yield
With lithium borohydride

187865-97-0

C43H47N3O7

187865-22-1

Derquantel

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: piperidine / tetrahydrofuran 2: 80 percent / NaBH4 / methanol / 0 °C View Scheme

187865-22-1

Derquantel

512848-25-8

14,17-anhydro-2-desoxoparaherquamide A

Conditions

Conditions	Yield
With dmap; diethylamino-sulfur trifluoride In dichloromethane at 20℃; for 1h;	50%

187865-22-1

Derquantel

512848-29-2

14-oxo-2-desoxo-1,2-anhydro-17-norparaherquamide A

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1: 50 percent / DMAP; (diethylamino)sulfurtrifluoride / CH2Cl2 / 1 h / 20 °C 2: 12 percent / osmium tetroxide; 4-methylmorpholine N-oxide / tetrahydrofuran; H2O; 2-methyl-propan-2-ol / 18 h / 5 °C 3: 41 percent / sodium periodate / tetrahydrofuran; H2O / 16 h / 5 °C View Scheme

187865-22-1

Derquantel

512848-28-1

14-oxo-2-desoxo-17-norparaherquamide A

Conditions

Conditions	Yield
Multi-step reaction with 4 steps 1: 50 percent / DMAP; (diethylamino)sulfurtrifluoride / CH2Cl2 / 1 h / 20 °C 2: 12 percent / osmium tetroxide; 4-methylmorpholine N-oxide / tetrahydrofuran; H2O; 2-methyl-propan-2-ol / 18 h / 5 °C 3: 41 percent / sodium periodate / tetrahydrofuran; H2O / 16 h / 5 °C 4: 50 percent / NaBH3CN / methanol / 0.5 h / 0 °C View Scheme
Multi-step reaction with 3 steps 1: 50 percent / DMAP; (diethylamino)sulfurtrifluoride / CH2Cl2 / 1 h / 20 °C 2: 25 percent / osmium tetroxide; 4-methylmorpholine N-oxide / tetrahydrofuran; H2O; 2-methyl-propan-2-ol / 18 h / 5 °C 3: 58 percent / sodium periodate / tetrahydrofuran; H2O / 16 h / 5 °C View Scheme

187865-22-1

Derquantel

512848-27-0

17-hydroxy-2-desoxo-1,2-anhydroparaherquamide A

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: 50 percent / DMAP; (diethylamino)sulfurtrifluoride / CH2Cl2 / 1 h / 20 °C 2: 12 percent / osmium tetroxide; 4-methylmorpholine N-oxide / tetrahydrofuran; H2O; 2-methyl-propan-2-ol / 18 h / 5 °C View Scheme

187865-22-1

Derquantel

512848-26-9

17-hydroxy-2-desoxoparaherquamide A

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: 50 percent / DMAP; (diethylamino)sulfurtrifluoride / CH2Cl2 / 1 h / 20 °C 2: 25 percent / osmium tetroxide; 4-methylmorpholine N-oxide / tetrahydrofuran; H2O; 2-methyl-propan-2-ol / 18 h / 5 °C View Scheme

187865-22-1

Derquantel

[17-D3]-2-desoxoparaherquamide A

Conditions

Conditions	Yield
Multi-step reaction with 4 steps 1.1: 50 percent / DMAP; (diethylamino)sulfurtrifluoride / CH2Cl2 / 1 h / 20 °C 2.1: 12 percent / osmium tetroxide; 4-methylmorpholine N-oxide / tetrahydrofuran; H2O; 2-methyl-propan-2-ol / 18 h / 5 °C 3.1: 41 percent / sodium periodate / tetrahydrofuran; H2O / 16 h / 5 °C 4.1: tetrahydrofuran / 1 h / -78 - 0 °C 4.2: 50 percent / NaBH3CN / methanol / 0.5 h / 0 °C View Scheme
Multi-step reaction with 5 steps 1.1: 50 percent / DMAP; (diethylamino)sulfurtrifluoride / CH2Cl2 / 1 h / 20 °C 2.1: 12 percent / osmium tetroxide; 4-methylmorpholine N-oxide / tetrahydrofuran; H2O; 2-methyl-propan-2-ol / 18 h / 5 °C 3.1: 41 percent / sodium periodate / tetrahydrofuran; H2O / 16 h / 5 °C 4.1: 50 percent / NaBH3CN / methanol / 0.5 h / 0 °C 5.1: tetrahydrofuran / 1 h / -78 - 0 °C 5.2: 20 percent / NaBH3CN / methanol / 0.5 h / 0 °C View Scheme
Multi-step reaction with 4 steps 1.1: 50 percent / DMAP; (diethylamino)sulfurtrifluoride / CH2Cl2 / 1 h / 20 °C 2.1: 25 percent / osmium tetroxide; 4-methylmorpholine N-oxide / tetrahydrofuran; H2O; 2-methyl-propan-2-ol / 18 h / 5 °C 3.1: 58 percent / sodium periodate / tetrahydrofuran; H2O / 16 h / 5 °C 4.1: tetrahydrofuran / 1 h / -78 - 0 °C 4.2: 20 percent / NaBH3CN / methanol / 0.5 h / 0 °C View Scheme

Derquantel Specification