Dibucaine Hydrochloride supplier

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Name
Dibucaine Hydrochloride
EINECS 200-498-1
CAS No. 61-12-1
Density 1.071g/cm3
Solubility Freely soluble in water, alcohol, acetone, or chloroform
Melting Point 99-101 °C(lit.)
Formula C₂₀H₃₀ClN₃O₂
Boiling Point 496.3 °C at 760 mmHg
Molecular Weight 379.98
Flash Point 254 °C
Transport Information
Appearance white powder
Safety 26-39
Risk Codes 22-41
Molecular Structure
Hazard Symbols Xn
Synonyms 4-Quinolinecarboxamide,2-butoxy-N-[2-(diethylamino)ethyl]-, monohydrochloride (9CI);Cinchoninamide,2-butoxy-N-[2-(diethylamino)ethyl]-, monohydrochloride (8CI);2-Butoxy-N-(2-diethylaminoethyl)cinchoninamide hydrochloride;2-Butoxy-N-(2-diethylaminoethyl)cinchoninic acid amide hydrochloride;2-n-Butoxy-N-(2-diethylaminoethyl)cinchoninamide hydrochloride;Benzolin (local anesthetic);Cincaine;Cincaine chloride;Cinchocainehydrochloride;Cinchocainium chloride;Nupercainehydrochloride;Percain;Percaine;Percamin S;Sovcain;Sovcaine;
PSA 54.46000
LogP 4.67820

Dibucaine Hydrochloride Chemical Properties

Empirical Formula: C₂₀H₃₀ClN₃O₂
Molecular Weight: 379.924100 g/mol
H bond acceptors: 5
H bond donors: 1
Freely Rotating Bonds: 10
Polar Surface Area: 42.43Å²
Flash Point: 254 °C
Enthalpy of Vaporization: 76.41 kJ/mol
Boiling Point: 496.3 °C at 760 mmHg
Vapour Pressure: 5.46E-10 mmHg at 25°C
EINECS: 200-498-1
Melting point: 99-101 °C(lit.)
Merck: 13,3057
Stability: Stable. Incompatible with strong oxidizing agents. Protect from moisture
Classification Code: Anesthetic [local]; Drug / Therapeutic Agent; Mutation data; Skin / Eye Irritant
InChI
InChI=1/C20H29N3O2.ClH/c1-4-7-14-25-19-15-17(16-10-8-9-11-18(16)22-19)20(24)21-12-13-23(5-2)6-3;/h8-11,15H,4-7,12-14H2,1-3H3,(H,21,24);1H
Smiles
c12c(cc(OCCCC)nc1cccc2)C(NCC[NH+](CC)CC)=O.[ClH-]
Following is the molecular structure of Dibucaine Hydrochloride (CAS NO.61-12-1):

Dibucaine Hydrochloride Uses

Dibucaine Hydrochloride (CAS NO.61-12-1) is used as Potent, long-acting local anesthetic. As a pethidine, it does not cause convulsions, although it produces the standard opioid side effects such as sedation and respiratory depression.

Dibucaine Hydrochloride Production

Dibucaine Hydrochloride (CAS NO.61-12-1) is formed by 2 - hydroxy-quinoline carboxylic acid by chlorination, condensation, ether-based, into a salt to be Cinchocaine.

Dibucaine Hydrochloride Toxicity Data With Reference

1.	eye-rbt 2% SEV	ARZNAD Arzneimittel-Forschung. Drug Research. 8 (1958),181.
2.	dnd-esc 15 µmol/L	MUREAV Mutation Research. 89 (1981),95.
3.	ipr-rat LD50:30 mg/kg	JPETAB Journal of Pharmacology and Experimental Therapeutics. 103 (1951),306.
4.	scu-rat LD50:27 mg/kg	DRUGAY Drugs. International Journal of Current Therapeutics and Applied Pharmacology Reviews .(ADIS Press Ltd.,Wanchai, Hong Kong.: )1990,478.
5.	ivn-rat LD50:52 mg/kg	DRUGAY Drugs. International Journal of Current Therapeutics and Applied Pharmacology Reviews .(ADIS Press Ltd.,Wanchai, Hong Kong.: )1990,478.
6.	ipr-mus LD50:29 mg/kg	JPETAB Journal of Pharmacology and Experimental Therapeutics. 94 (1948),299.
7.	scu-mus LD50:25,400 µg/kg	PSEBAA Proceedings of the Society for Experimental Biology and Medicine. 103 (1960),353.
8.	ivn-mus LD50:5151 µg/kg	JAPMA8 Journal of the American Pharmaceutical Association, Scientific Edition. 44 (1955),393.
9.	scu-rbt LDLo:5 mg/kg	ODFU** Vergleichende pharmakologische Prufung Zweier neuer Lokalanas-thetika: Perkain und Pantokain, Wilhelm Ost Dissertation .(Pharmakologischen Institut der Universitat zu Frankfurt am Ma

Dibucaine Hydrochloride Safety Profile

Poison by ingestion, subcutaneous, intravenous, intraspinal, parenteral, and intraperitoneal routes. Mutation data reported. A severe eye irritant. A local anesthetic. When heated to decomposition it emits very toxic fumes of HCl and NO_x
Safety Information of Dibucaine Hydrochloride (CAS NO.61-12-1):
Hazard Codes: Xn
Xn: Harmful
Risk Statements: 22-41
22: Harmful if swallowed
41: Risk of serious damage to eyes
Safety Statements: 26-39
26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice
39: Wear eye/face protection
WGK Germany: 3
RTECS: GD3325000

Dibucaine Hydrochloride Specification

Dibucaine Hydrochloride , with CAS number of 61-12-1, can be called 2-Butoxy-N-(2-(diethylamino)ethyl)cinchoninamide monohydrochloride ; 2-Butoxy-N-(2-diethylaminoethyl)cinchoninamide hydrochloride ; 2-Butoxy-N-(2-diethylaminoethyl)cinchoninic acid amide hydrochloride ; 2-N-Butoxy-N-(2-diethylaminoethyl)cinchoninamide hydrochloride ; 4-Quinolinecarboxamide, 2-butoxy-N-(2-(diethylamino)ethyl)-, monohydrochloride ; Benzolin (local anesthetic) ; Butoxycinchoninic acid diethylethylenediamide hydrochloride ; Cincaine chloride ; Dibucaine HCl . It is a white powder.

Product Name

Dibucaine Hydrochloride