Product Name

  • Name

    8-[(dimethylamino)methyl]-7-methoxy-3-methyl-2-phenyl-4-benzopyrone hydrochloride

  • EINECS
  • CAS No. 2740-04-7
  • Density
  • Solubility
  • Melting Point
  • Formula C20H21NO3•ClH
  • Boiling Point 465.3oC at 760 mmHg
  • Molecular Weight 359.88
  • Flash Point 235.2oC
  • Transport Information
  • Appearance
  • Safety Poison by ingestion, intraperitoneal, and subcutaneous routes. When heated to decomposition it emits very toxic fumes of HCl and NOx.
  • Risk Codes R20/21/22
  • Molecular Structure Molecular Structure of 2740-04-7 (8-[(dimethylamino)methyl]-7-methoxy-3-methyl-2-phenyl-4-benzopyrone hydrochloride)
  • Hazard Symbols
  • Synonyms DIMEFLINE HYDROCHLORIDE;
  • PSA 42.68000
  • LogP 4.64060

Dimefline hydrochloride Chemical Properties

IUPAC Name: 8-(dimethylaminomethyl)-7-methoxy-3-methyl-2-phenylchromen-4-one hydrochloride
Molecular Formula: C20H21NO3•HCl
Molecular Weight: 359.88g/mol 
Properties: white crystalline powder
Density: 1.163 g/cm3 
EINECS: 220-366-7 
Transport information: UN 2811 6.1
Melting Point: 212 ~ 217 °C
Boiling Point: 465.3 °C at 760 mmHg 
Flash Point: 235.2 °C
Freely Rotating Bonds: 4
Polar Surface Area: 38.77 Å2
Index of Refraction: 1.587
Molar Refractivity: 93.49 cm3
Molar Volume: 277.8 cm3
Polarizability: 37.06 ×10-24 cm3
Surface Tension: 43.9 dyne/cm
Enthalpy of Vaporization: 72.68 kJ/mol
Vapour Pressure: 7.81E-09 mmHg at 25°C 
The Cas Register Number of Dimefline hydrochloride is 2740-04-7.The chemical synonyms of Dimefline hydrochloride (CAS NO.2740-04-7) are 4H-1-Benzopyran-4-one, 8-[(dimethylamino)methyl]-7-methoxy-3-methyl-2-phenyl-  ; 8-[(Dimethylamino)methyl]-7-methoxy-3-methyl-2-phenyl-4H-1-benzopyran-4-one ; 8-[(Dimethylamino)methyl]-7-methoxy-3-methylflavone ; Dimefline ; 3-Methyl-7-methoxy-8-dimethylamino-methylflavone ; 4H-1-Benzopyran-4-one, 8-((dimethylamino)methyl)-7-methoxy-3-methyl-2-phenyl-  .The molecular structure of Dimefline hydrochloride (CAS NO.2740-04-7) is.

Dimefline hydrochloride Uses

 Dimefline hydrochloride (CAS NO.2740-04-7) is used as central stimulant.

Dimefline hydrochloride Toxicity Data With Reference

1.    

orl-rat LD50:14 mg/kg

    NIIRDN    “Drugs in Japan. Ethical Drugs, 6th Edition 1982“ Edited by Japan Pharmaceutical Information Center. 6 (1982),345.
2.    

orl-mus LD50:12 mg/kg

    JPETAB    Journal of Pharmacology and Experimental Therapeutics. 128 (1960),176.
3.    

ipr-mus LD50:5 mg/kg

    JPETAB    Journal of Pharmacology and Experimental Therapeutics. 128 (1960),176.
4.    

scu-mus LD50:4 mg/kg

    JPETAB    Journal of Pharmacology and Experimental Therapeutics. 128 (1960),176.

Dimefline hydrochloride Safety Profile

Poison by ingestion, intraperitoneal, and subcutaneous routes. When heated to decomposition it emits very toxic fumes of HCl and NOx.
Hazard Codes: HarmfulXn
Risk Statements: 20/21/22 
R20/21/22: Harmful by inhalation, in contact with skin and if swallowed.
Safety Statements: 36 
S36: Wear suitable protective clothing.

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