Product Name

  • Name

    Dimemorfan phosphate

  • EINECS 252-958-6
  • CAS No. 36304-84-4
  • Article Data3
  • CAS DataBase
  • Density 1.07g/cm3
  • Solubility
  • Melting Point 267-269°
  • Formula C18H25N.H3O4P
  • Boiling Point 366.9°Cat760mmHg
  • Molecular Weight 353.398
  • Flash Point 158.3°C
  • Transport Information
  • Appearance
  • Safety Poison by intravenous, intraperitoneal, and subcutaneous routes. Moderately toxic by ingestion. An experimental teratogen. Experimental reproductive effects. Used as an antitussive agent. When heated to decomposition it emits very toxic fumes of NOx and POx. See also PHOSPHATES.
  • Risk Codes
  • Molecular Structure Molecular Structure of 36304-84-4 (Dimemorfan phosphate)
  • Hazard Symbols
  • Synonyms DIMEMORFAN PHOSPHATE;(9alpha,13alpha,14alpha)-3,17-dimethylmorphinan dihydrogen phosphate;Astomin;dimemorphan phosphate;Morphinan, 3,17-dimethyl-, (9α,13α,14α)-, phosphate (1:1)
  • PSA 90.81000
  • LogP 2.69250

Dimemorfan phosphate Chemical Properties

D-3-methyl-N-methylmorphinan phosphate(36304-84-4) exists as bitter-tasting crystals. D-3-methyl-N-methylmorphinan phosphate(36304-84-4) is slightly soluble in H2O and methanol, and it is insoluble in acetone, ethanol, ether.
Molecular Formula: C18H25N.H3O4P.
Molecular Weight: 353.44.
Density: 1.07g/cm3.
Boiling Point: 366.9 ℃ at 760mmHg.
Flash Point: 158.3 ℃.
Molecular Structure:

Dimemorfan phosphate Uses

D-3-methyl-N-methylmorphinan phosphate(36304-84-4) is neuroprotective to inflammation-mediated neurodegenerative diseases through mechanisms of σ1 receptors. D-3-methyl-N-methylmorphinan phosphate(36304-84-4), an analogue of dextromethorphan, is used as nonopioid antitussive.

Dimemorfan phosphate Toxicity Data With Reference

1.   

orl-rat LD50:690 mg/kg

   MEIEDD    Merck Index. 10 (1983),466.
2.   

ipr-rat LD50:124 mg/kg

   OYYAA2    Oyo Yakuri. Pharmacometrics. 6 (1972),1207.
3.   

scu-rat LD50:556 mg/kg

   NIIRDN    “Drugs in Japan. Ethical Drugs, 6th Edition 1982” Edited by Japan Pharmaceutical Information Center. 6 (1982),345.
4.   

ivn-rat LD50:57 mg/kg

   MEIEDD    Merck Index. 10 (1983),466.
5.   

orl-mus LD50:475 mg/kg

   ARZNAD    Arzneimittel-Forschung. Drug Research. 26 (1976),353.
6.   

scu-mus LD50:223 mg/kg

   ARZNAD    Arzneimittel-Forschung. Drug Research. 26 (1976),353.
7.   

ivn-mus LD50:33,900 µg/kg

   OYYAA2    Oyo Yakuri. Pharmacometrics. 6 (1972),1207.
8.   

ivn-dog LD50:35 mg/kg

   ARZNAD    Arzneimittel-Forschung. Drug Research. 26 (1976),353.

Dimemorfan phosphate Safety Profile

Poison by intravenous, intraperitoneal, and subcutaneous routes. Moderately toxic by ingestion. An experimental teratogen. Experimental reproductive effects. Used as an antitussive agent. When heated to decomposition it emits very toxic fumes of NOx and POx. See also PHOSPHATES.

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