Conditions | Yield |
---|---|
With ammonia; hydrogen at 200℃; under 150015 Torr; Reagent/catalyst; Temperature; | 95% |
Conditions | Yield |
---|---|
With ammonium hydroxide at 120℃; | |
With ammonium hydroxide at 120℃; |
Conditions | Yield |
---|---|
With sodium hydroxide Erhitzen des Reaktionsprodukts mit H2SO4 auf 180grad; |
Conditions | Yield |
---|---|
With sulfuric acid at 170℃; |
Conditions | Yield |
---|---|
Reaktion ueber mehrere Stufen; |
Conditions | Yield |
---|---|
at 160 - 170℃; |
2,6-dimethyl-N-(2-hydroxypropyl)-morpholine
A
2,6-dimethyl morpholine
Conditions | Yield |
---|---|
With nitrogen In water; SiO2 |
2,6-dimethyl-N-(2-hydroxypropyl)-morpholine
2,6-dimethyl morpholine
Conditions | Yield |
---|---|
In water |
Conditions | Yield |
---|---|
With ammonia; hydrogen at 180℃; under 150015 Torr; Temperature; Overall yield = 66.3 %; |
morpholine
methanol
A
4-methyl-morpholine
B
2,6-dimethyl morpholine
Conditions | Yield |
---|---|
With Iridium(II)-coordinated mesoporous (4-[5-(4-aminophenyl)-4'-methyl-[1,1'-biphenyl]-3-yl]aniline)-modified Tröger’s base-functionalized polymer at 110℃; for 24h; Catalytic behavior; Reagent/catalyst; Temperature; | A 89 %Chromat. B n/a |
2,6-dimethyl morpholine
trimethylsilyl isocyanate
2,6-dimethyl-morpholine-4-carboxylic acid amide
Conditions | Yield |
---|---|
In isopropyl alcohol at 20℃; | 100% |
2,6-dimethyl morpholine
benzyl 3-nitro-1H-1,2,4-triazole-1-carboxylate
benzyl 2,6-dimethylmorpholine-4-carboxylate
Conditions | Yield |
---|---|
In dichloromethane at 20℃; for 0.0833333h; | 100% |
2,6-dimethyl morpholine
9-fluorenylmethyl 3-nitro-1H-1,2,4-triazole-1-carboxylate
(9H-fluoren-9-yl)methyl 2,6-dimethylmorpholine-4-carboxylate
Conditions | Yield |
---|---|
In dichloromethane at 20℃; for 0.0833333h; | 100% |
2,6-dimethyl morpholine
2-(trimethylsilyl)ethyl 3-nitro-1H-1,2,4-triazole-1-carboxylate
2-(trimethylsilyl)ethyl 2,6-dimethylmorpholine-4-carboxylate
Conditions | Yield |
---|---|
In dichloromethane at 20℃; for 0.0833333h; | 100% |
Conditions | Yield |
---|---|
With potassium carbonate In acetonitrile Reflux; | 100% |
With potassium carbonate In acetonitrile Reflux; |
2,6-dimethyl morpholine
Ethylchlor<4-(3-chlorphenyl)-piperazin-1-ylamido>phosphat
Conditions | Yield |
---|---|
With potassium carbonate In acetonitrile at 80℃; | 99% |
2,6-dimethyl morpholine
Ethylchlor<4-(2-chlorphenyl)-piperazin-1-ylamido>phosphat
Conditions | Yield |
---|---|
With potassium carbonate In acetonitrile at 80℃; | 99% |
2,6-dimethyl morpholine
Ethylchlor<4-(3-trifluormethylphenyl)-piperazin-1-ylamido>phosphat
Conditions | Yield |
---|---|
With potassium carbonate In acetonitrile at 80℃; | 99% |
2,6-dimethyl morpholine
(4-chlorophenyl)(3-chloropropyl)methylpropylsilane
Conditions | Yield |
---|---|
With sodium iodide 90-100 deg C, 2 h, then toluene, reflux, 48 h; | 99% |
Conditions | Yield |
---|---|
In ethanol for 3h; Reflux; | 99% |
2,6-dimethyl morpholine
(benzyloxy)benzene
4-cyclohexyl-2,6-dimethylmorpholine
Conditions | Yield |
---|---|
With palladium 10% on activated carbon; hydrogen In m-xylene at 90℃; under 7500.75 Torr; for 6h; Autoclave; Green chemistry; | 99% |
2,6-dimethyl morpholine
Ethylchlor<<2-(2,6-dichlorphenoxy)-ethyl>-propylamido>phosphat
Conditions | Yield |
---|---|
With potassium carbonate In acetonitrile at 80℃; | 98% |
Conditions | Yield |
---|---|
With dmap In N,N-dimethyl-formamide 1) 0 deg C, 2-3 h, 2) room temperature, 20-24 h; | 98% |
With dmap In acetonitrile at 0 - 20℃; for 26h; Schlenk technique; Inert atmosphere; |
2,6-dimethyl morpholine
1-Bromo-3-phenylpropane
1-N-(2',6'-dimethyl-morpholino)-3-phenyl-propane
Conditions | Yield |
---|---|
Heating; | 98% |
Conditions | Yield |
---|---|
With N-ethyl-N,N-diisopropylamine In acetonitrile at 90℃; | 98% |
2,6-dimethyl morpholine
Conditions | Yield |
---|---|
With potassium carbonate In N,N-dimethyl-formamide at 150℃; for 0.5h; Microwave irradiation; | 97.7% |
2,6-dimethyl morpholine
cyclododecanone
dodemorph
Conditions | Yield |
---|---|
With hydrogen; ZrO2-containing catalyst at 220 - 240℃; under 37503.8 Torr; | 97% |
2,6-dimethyl morpholine
7-chloro-1-(2,4-difluorophenyl)-1,4-dihydro-8-methyl-6-nitro-4-oxoquinolone-3-carboxylic acid
1-(2,4-difluorophenyl)-1,4-dihydro-7-(2,6-dimethylmorpholin-4-yl)-8-methyl-6-nitro-4-oxoquinoline-3-carboxylic acid
Conditions | Yield |
---|---|
With potassium carbonate In dimethyl sulfoxide Microwave irradiation; | 97% |
2,6-dimethyl morpholine
(4-chlorobutyl)(4-chlorophenyl)(3-chloropropyl)methylsilane
Conditions | Yield |
---|---|
With sodium iodide 90-100 deg C, 2xh, then toluene, reflux, 48 h; | 96% |
2,6-dimethyl morpholine
Bis-(4-chloro-phenyl)-(3-chloro-propyl)-methyl-silane
Conditions | Yield |
---|---|
With sodium iodide 90-100 deg C, 2 h, then reflux, 48 h; | 96% |
2,6-dimethyl morpholine
Ethylchlor<<2-(2,4,6-trichlorphenoxy)-ethyl>-propylamido>phosphat
Conditions | Yield |
---|---|
With potassium carbonate In acetonitrile at 80℃; | 95% |
2,6-dimethyl morpholine
2,3,3,4,5,5,6-Heptafluoro-2,6-bis-trifluoromethyl-morpholine
Conditions | Yield |
---|---|
With fluorine at -100 - 25℃; | 95% |
2,6-dimethyl morpholine
4-methyl-N-2-propen-1-yl-N-[2-[tris(1-methylethyl)silyl]ethynyl]-benzenesulfonamide
Conditions | Yield |
---|---|
With bis-triphenylphosphine-palladium(II) chloride; potassium carbonate In tetrahydrofuran at 80℃; Inert atmosphere; | 95% |
2,6-dimethyl morpholine
2,2,2-trichloroethyl 3-nitro-1H-1,2,4-triazole-1-carboxylate
2,2,2-trichloroethyl 2,6-dimethylmorpholine-4-carboxylate
Conditions | Yield |
---|---|
In dichloromethane at 20℃; for 0.0833333h; | 94% |
2,6-dimethyl morpholine
ethyl 4,5-dimethyl-2-(1H-tetrazol-1-yl)thiophene-3-carboxylate
Conditions | Yield |
---|---|
In neat (no solvent) at 80 - 90℃; for 0.5h; | 94% |
2,6-dimethyl morpholine
Conditions | Yield |
---|---|
With potassium iodide In tetrahydrofuran; N,N,N,N,N,N-hexamethylphosphoric triamide; water; ethyl acetate | 93% |
2,6-dimethyl morpholine
3-chloro-1,2-dimethyl-5-phenylpyrazolium iodide
Conditions | Yield |
---|---|
In ethanol Heating; | 92% |
2,6-dimethyl morpholine
(4-chlorophenyl)(3-chloropropyl)methyl(prop-2-en-1-yl)silane
Conditions | Yield |
---|---|
With sodium iodide 90-100 deg C, 2 h, then toluene, reflux, 48 h; | 92% |
The Dimethylmorpholine, with the CAS registry number 141-91-3, is also known as 2,6-Dimethyl-2,3,5,6-tetrahydro-4H-1,4-oxazine. It belongs to the product categories of Building Blocks; Heterocyclic Building Blocks; Morpholines. Its EINECS number is 205-509-3. This chemical's molecular formula is C6H13NO and molecular weight is 115.17. What's more, its systematic name is 2,6-Dimethylmorpholine. Its classification codes are: (1)Mutation data; (2)Skin / Eye Irritant. This chemical is stable at common pressure and temperature, and it should be sealed and stored. Moreover, it should be protected from strong oxidants and acids. It is used as an intermediate for SBR morpholine and also used in the manufacture of corrosion inhibitors, stabilizer for chlorinated solvents, rubless floor polishes, rubber accelerators, germicides.
Physical properties of Dimethylmorpholine are: (1)ACD/LogP: 0.281; (2)# of Rule of 5 Violations: 0; (3)ACD/LogD (pH 5.5): -2.69; (4)ACD/LogD (pH 7.4): -1.36; (5)ACD/BCF (pH 5.5): 1.00; (6)ACD/BCF (pH 7.4): 1.00; (7)ACD/KOC (pH 5.5): 1.00; (8)ACD/KOC (pH 7.4): 1.00; (9)#H bond acceptors: 2; (10)#H bond donors: 1; (11)#Freely Rotating Bonds: 0; (12)Polar Surface Area: 21.26 Å2; (13)Index of Refraction: 1.406; (14)Molar Refractivity: 32.816 cm3; (15)Molar Volume: 133.514 cm3; (16)Polarizability: 13.009×10-24cm3; (17)Surface Tension: 24.24 dyne/cm; (18)Density: 0.863 g/cm3; (19)Flash Point: 48.889 °C; (20)Enthalpy of Vaporization: 38.36 kJ/mol; (21)Boiling Point: 146.599 °C at 760 mmHg; (22)Vapour Pressure: 4.6 mmHg at 25°C.
Preparation: this chemical can be prepared by 2-(2-hydroxyl propyl) amine hydrochloride and concentrated sulfuric acid by heating to dehydration, and then add alkali to separate out the product. The end product is got by distillation.
Uses of Dimethylmorpholine: it can be used to produce 2,7-dichloro-4-(2,6-dimethylmorpholino)quinazoline at the temperature of 0 °C. It will need solvent CH2Cl2 with the reaction time of 45 min. The yield is about 74%.
When you are using this chemical, please be cautious about it as the following:
This chemical is flammable, so you should keep it away from sources of ignition - No smoking. It is harmful in contact with skin and has a risk of serious damage to eyes. In case of contact with eyes, you should rinse immediately with plenty of water and seek medical advice. When using it, you need to wear suitable protective clothing and avoid contact with skin and eyes. In case of accident or if you feel unwell, you must seek medical advice immediately (show the label where possible).
You can still convert the following datas into molecular structure:
(1)SMILES: O1C(C)CNCC1C
(2)Std. InChI: InChI=1S/C6H13NO/c1-5-3-7-4-6(2)8-5/h5-7H,3-4H2,1-2H3
(3)Std. InChIKey: HNVIQLPOGUDBSU-UHFFFAOYSA-N
The toxicity data is as follows:
Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
---|---|---|---|---|---|
rabbit | LD50 | skin | 710uL/kg (.71mL/kg) | SKIN AND APPENDAGES (SKIN): PRIMARY IRRITATION: AFTER TOPICAL EXPOSURE | American Industrial Hygiene Association Journal. Vol. 23, Pg. 95, 1962. |
rat | LC | inhalation | > 4000ppm/4H (4000ppm) | American Industrial Hygiene Association Journal. Vol. 23, Pg. 95, 1962. | |
rat | LD50 | oral | 2830mg/kg (2830mg/kg) | Union Carbide Data Sheet. Vol. 11/13/1961. |
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