-
Name
Eflornithine hydrochloride
- EINECS 269-532-0
- CAS No. 68278-23-9
- Density
- Solubility >10 mg/mL in water
- Melting Point 181-184 °C
- Formula C6H13ClF2N2O2
- Boiling Point 347 °C at 760 mmHg
- Molecular Weight 218.63
- Flash Point 163.7 °C
- Transport Information
- Appearance white solid
- Safety
- Risk Codes
-
Molecular Structure
- Hazard Symbols
- Synonyms DL-Ornithine,2-(difluoromethyl)-, monohydrochloride;Ornithine, 2-(difluoromethyl)-,monohydrochloride (9CI);NSC 270295;NSC 337250;Vaniqa;
- PSA 89.34000
- LogP 1.97510
Eflornithine hydrochloride Chemical Properties
Molecular structure of 2-(Difluoromethyl)-DL-ornithine monohydrochloride (CAS NO.68278-23-9) is:
Product Name: 2-(Difluoromethyl)-DL-ornithine monohydrochloride
CAS Registry Number: 68278-23-9
IUPAC Name: 2,5-diamino-2-(difluoromethyl)pentanoic acid hydrochloride
Molecular Weight: 218.629426 [g/mol]
Molecular Formula: C6H13ClF2N2O2
H-Bond Donor: 4
H-Bond Acceptor: 6
EINECS: 269-532-0
Melting Point: 181-184 °C
Solubility H2O: >10 mg/mL, soluble
Flash Point: 163.7 °C
Enthalpy of Vaporization: 64.97 kJ/mol
Boiling Point: 347 °C at 760 mmHg
Vapour Pressure: 9.72E-06 mmHg at 25°C
Other Registry Number: 70050-56-5
Product Categories: Amino Acids and Derivatives; facial hair remover
Eflornithine hydrochloride Toxicity Data With Reference
| Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
|---|---|---|---|---|---|
| mouse | LD50 | intraperitoneal | > 3gm/kg (3000mg/kg) | Drugs of the Future. Vol. 6, Pg. 142, 1981. | |
| mouse | LD50 | oral | > 5gm/kg (5000mg/kg) | Drugs of the Future. Vol. 6, Pg. 142, 1981. | |
| rat | LD50 | intraperitoneal | > 3gm/kg (3000mg/kg) | Drugs of the Future. Vol. 6, Pg. 142, 1981. | |
| rat | LD50 | oral | > 5gm/kg (5000mg/kg) | Drugs of the Future. Vol. 6, Pg. 142, 1981. |
Eflornithine hydrochloride Safety Profile
Low toxicity by ingestion and intraperitoneal routes. An experimental teratogen. Other experimental reproductive effects. When heated to decomposition it emits toxic fumes of NOx and F−.
WGK Germany: 3
Eflornithine hydrochloride Specification
2-(Difluoromethyl)-DL-ornithine monohydrochloride , its cas register number is 68278-23-9. It also can be called 2-(Difluoromethyl)-DL-ornithine HCl ; 2-(Difluoromethyl)-DL-ornithine hydrochloride ; CCRIS 5805 ; DL-Ornithine, 2-(difluoromethyl)-, monohydrochloride ; Eflornithine hydrochloride ; D,L-alpha-Difluoromethylornithine hydrochloride ; Ornithine, 2-(difluoromethyl)-, monohydrochloride . It is a white solid.
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