-
Name
EPIDERMAL GROWTH FACTOR, HUMAN
- EINECS 263-468-7
- CAS No. 62229-50-9
- Density
- Solubility
- Melting Point
- Formula C257H381N73O83S7
- Boiling Point
- Molecular Weight 6045.66934
- Flash Point powder
- Transport Information
- Appearance
- Safety Human mutation data reported.
- Risk Codes
-
Molecular Structure
- Hazard Symbols B
- Synonyms Urogastrone (8CI);Anthelone U;EGF;Gastrone, uro-;Gastrone, g-uro-;Kutrol;Uroanthelone;Uroenterone;Urogastron;Epidermal growth factor;
- PSA 0.00000
- LogP 0.00000
Epidermal growth factor Chemical Properties
Product Name: Epidermal growth factor
EINECS of Epidermal growth factor (CAS NO.62229-50-9): 263-468-7
Storage tempreture: 2-8 °C
Form: Powder
Epidermal growth factor History
The discovery of EGF won Stanley Cohen a Nobel Prize in Physiology and Medicine in 1986, and in 1989, Epidermal growth factor (CAS NO.62229-50-9) was patented for cosmetic use by Greg Brown.
Epidermal growth factor Toxicity Data With Reference
| Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
|---|---|---|---|---|---|
| mouse | LD50 | intramuscular | 7900mg/kg (7900mg/kg) | Japanese Kokai Tokyo Koho Patents. Vol. #85-23325, | |
| mouse | LD50 | intraperitoneal | 5080mg/kg (5080mg/kg) | Japanese Kokai Tokyo Koho Patents. Vol. #85-23325, | |
| mouse | LD50 | intravenous | 2850mg/kg (2850mg/kg) | Japanese Kokai Tokyo Koho Patents. Vol. #85-23325, | |
| mouse | LD50 | oral | 12600mg/kg (12600mg/kg) | Drugs in Japan Vol. 6, Pg. 96, 1982. | |
| rat | LD50 | intravenous | 1990mg/kg (1990mg/kg) | Japanese Kokai Tokyo Koho Patents. Vol. #85-23325, | |
| rat | LD50 | oral | > 15gm/kg (15000mg/kg) | Drugs in Japan Vol. 6, Pg. 96, 1982. |
Epidermal growth factor Safety Profile
Hazard Codes of Epidermal growth factor (CAS NO.62229-50-9): 
B
WGK Germany: 3
RTECS: KB4518000
F: 10-21
Moderately toxic by intravenous route. Mildly toxic by ingestion.
Epidermal growth factor Specification
Epidermal growth factor ,its cas register number is 62229-50-9. It also can be called EGF ; and beta-Urogastrone . Epidermal growth factor (CAS NO.62229-50-9) is a growth factor that plays an important role in the regulation of cell growth, and differentiation by binding to its receptor EGFR. It is a low-molecular-weight polypeptide first purified from the mouse submandibular gland, and results in cellular proliferation, differentiation, and survival. It acts by binding with high affinity to epidermal growth factor receptor on the cell surface and stimulating the intrinsic protein-tyrosine kinase activity of the receptor. inhibiting it decreases cancer risk for the increased risk of cancer by EGF.
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