Epipodophyllotoxin supplier

Name
(5R)-5β-(3,4,5-Trimethoxyphenyl)-7α-(hydroxymethyl)-8α-hydroxy-5,6,7,8-tetrahydronaphtho[2,3-d]-1,3-dioxole-6β-carboxylic acid 6,7-lactone
EINECS
CAS No. 4375-07-9
Article Data46
CAS DataBase
Density 1.2649 (rough estimate)
Solubility
Melting Point 160.3°C
Formula C22H22 O8
Boiling Point 453.31°C (rough estimate)
Molecular Weight 414.412
Flash Point 210.2oC
Transport Information
Appearance
Safety Experimental reproductive effects. Mutation data reported. When heated to decomposition it emits acrid smoke and irritating fumes.
Risk Codes
Molecular Structure
Hazard Symbols
Synonyms Epipodophyllotoxin(6CI,8CI); Furo[3',4':6,7]naphtho[2,3-d]-1,3-dioxol-6(5aH)-one,5,8,8a,9-tetrahydro-9-hydroxy-5-(3,4,5-trimethoxyphenyl)-, [5R-(5a,5ab,8aa,9b)]-; (-)-Epipodophyllotoxin
PSA 92.68000
LogP 2.40920

Epipodophyllotoxin Chemical Properties

IUPAC Name: (5S,5aR,8aR,9R)-5-Hydroxy-9-(3,4,5-trimethoxyphenyl)-5a,6,8a,9-tetrahydro-5H-[2]benzofuro[5,6-f][1,3]benzodioxol-8-one
Synonyms of Epipodophyllotoxin (CAS NO.4375-07-9): Furo(3',4':6,7)naphtho(2,3-d)-1,3-dioxol-6(5aH)-one, 5,8,8a,9-tetrahydro-9-hydroxy-5-(3,4,5-trimethoxyphenyl)-, (5R,5aR,8aR,9S)- ; Furo(3',4':6,7)naphtho(2,3-d)-1,3-dioxol-6(5aH)-one, 5,8,8a,9-tetrahydro-9-hydroxy-5-(3,4,5-trimethoxyphenyl)-, (5R-(5-alpha,5a-beta,8a-alpha,9-beta))- ; Etopside
CAS NO: 4375-07-9
Molecular Formula: C₂₂H₂₂O₈
Molecular Weight : 414.405280 g/mol
Molecular Structure:
H bond acceptors: 1
H bond donors: 0
H bond acceptors: 8
H bond donors: 1
Freely Rotating Bonds: 5
Polar Surface Area: 81.68 Å²
Index of Refraction: 1.605
Molar Refractivity: 104.28 cm³
Molar Volume: 302.3 cm³
Surface Tension: 52.7 dyne/cm
Density: 1.37 g/cm³
Flash Point: 210.2 °C
Enthalpy of Vaporization: 93.64 kJ/mol
Boiling Point: 597.9 °C at 760 mmHg
Vapour Pressure: 3.82E-15 mmHg at 25°C

Epipodophyllotoxin Toxicity Data With Reference

1.		dni-hmn:hlas 800 nmol/L		BICHAW Biochemistry. 15 (1976),5443.
2.		oth-hmn:hlas 5 µmol/L		BICHAW Biochemistry. 15 (1976),5443.

Epipodophyllotoxin Safety Profile

Experimental reproductive effects. Mutation data reported. When Epipodophyllotoxin (CAS NO.4375-07-9) is heated to decomposition, it emits acrid smoke and irritating fumes.

Epipodophyllotoxin Specification

Epipodophyllotoxins are alkaloids naturally occurring in the root of American Mayapple plant (Podophyllum peltatum).

Some epipodophyllotoxin derivatives are currently used in the treatment of cancer. These include etoposide and teniposide. They act as anti-cancer drugs by inhibiting topoisomerase II.

Product Name

(5R)-5β-(3,4,5-Trimethoxyphenyl)-7α-(hydroxymethyl)-8α-hydroxy-5,6,7,8-tetrahydronaphtho[2,3-d]-1,3-dioxole-6β-carboxylic acid 6,7-lactone

Epipodophyllotoxin Chemical Properties

Epipodophyllotoxin Toxicity Data With Reference

Epipodophyllotoxin Safety Profile

Epipodophyllotoxin Specification

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