Product Name

  • Name

    Epirizole

  • EINECS 242-507-1
  • CAS No. 18694-40-1
  • Article Data12
  • CAS DataBase
  • Density 1.25g/cm3
  • Solubility
  • Melting Point 90-92°
  • Formula C11H14 N4 O2
  • Boiling Point 444°Cat760mmHg
  • Molecular Weight 234.258
  • Flash Point 222.3°C
  • Transport Information
  • Appearance Yellow power
  • Safety Poison by subcutaneous, intravenous and intraperitoneal routes. Moderately toxic by ingestion. Experimental reproductive effects. When heated to decomposition it emits toxic fumes of NOx.
  • Risk Codes R20/21/22;R36/37/38   
  • Molecular Structure Molecular Structure of 18694-40-1 (Epirizole)
  • Hazard Symbols
  • Synonyms Pyrimidine,4-methoxy-2-(5-methoxy-3-methylpyrazol-1-yl)-6-methyl- (8CI); 1-(4-Methoxy-6-methyl-2-pyrimidinyl)-3-methyl-5-methoxypyrazole;1-(4-Methyl-6-methoxy-2-pyrimidinyl)-3-methyl-5-methoxypyrazole;2-(3-Methoxy-5-methylpyrazol-2-yl)-4-methoxy-6-methylpyrimidine;2-(3-Methyl-5-methoxy-1-pyrazolyl)-4-methoxy-6-methylpyrimidine; 4-Methoxy-2-(5-methoxy-3-methylpyrazol-1-yl)-6-methylpyrimidine;DA 398; Epirizole; Mebron; Mepirizole
  • PSA 62.06000
  • LogP 1.29630

Epirizole Chemical Properties

Product Name: Mepirizol (CAS NO.18694-40-1)


Molecular Formula: C11H14N4O2
Molecular Weight: 234.25g/mol
Mol File: 18694-40-1.mol
Einecs: 242-507-1
Appearance: White or cream-colored crystals
Boiling point: 444 °C at 760 mmHg
Storage Temperature: 2-8°C
Flash Point: 222.3 °C
Density: 1.25 g/cm3
Surface Tension: 40.1 dyne/cm
Enthalpy of Vaporization: 70.17 kJ/mol
Vapour Pressure: 4.43E-08 mmHg at 25°C
XLogP3: 1.3
H-Bond Donor: 0
H-Bond Acceptor: 5

Epirizole Toxicity Data With Reference

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intraperitoneal 540mg/kg (540mg/kg) BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY)

BEHAVIORAL: ATAXIA

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION		 Oyo Yakuri. Pharmacometrics. Vol. 16, Pg. 1011, 1978.
mouse LD50 intravenous 550mg/kg (550mg/kg)   Japan Medical Gazette. Vol. 7(9), Pg. 5, 1970.
mouse LD50 oral 740mg/kg (740mg/kg) BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY)

BEHAVIORAL: ATAXIA

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION		 Oyo Yakuri. Pharmacometrics. Vol. 16, Pg. 1011, 1978.
mouse LD50 subcutaneous 550mg/kg (550mg/kg)   Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 8, Pg. 494, 1977.
rat LD50 intraperitoneal 214mg/kg (214mg/kg)   Japan Medical Gazette. Vol. 7(9), Pg. 5, 1970.
rat LD50 intravenous 214mg/kg (214mg/kg)   "Modern Pharmaceuticals of Japan, V," Tokyo, Japan Pharmaceutical, Medical and Dental Supply Exporters' Assoc., 1975Vol. -, Pg. 87, 1975.
rat LD50 oral 445mg/kg (445mg/kg)   Japan Medical Gazette. Vol. 7(9), Pg. 5, 1970.
rat LD50 subcutaneous 208mg/kg (208mg/kg)   Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 8, Pg. 494, 1977.

Epirizole Safety Profile

Poison by subcutaneous, intravenous and intraperitoneal routes. Moderately toxic by ingestion. Experimental reproductive effects. When heated to decomposition it emits toxic fumes of NOx.
Safety Information of Mepirizol (CAS NO.18694-40-1):
Hazard Codes: Xn
Risk Statements: 20/21/22-36/37/38 
20:  Harmful by inhalation 
21:  Harmful in contact with skin 
22:  Harmful if swallowed 
36:  Irritating to the eyes 
37:  Irritating to the respiratory system 
38:  Irritating to the skin
Safety Statements: 26-36
26:  In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 
36:  Wear suitable protective clothing

Epirizole Specification

 Mepirizol ,its CAS NO. is 18694-40-1,the synonyms is 1-(4-Methoxy-6-methyl-2-pyrimidinyl)-3-methyl-5-methoxypyrazole ; 2-(3-Methoxy-5-methylpyrazol-2-yl)-4-methoxy-6-methylpyrimidine ; 2-(3-Methyl-5-methoxy-1-pyrazolyl)-4-methoxy-6-methylpyrimidine ; 4-Methoxy-2-(5-methoxy-3-methyl-1h-pyrazol-1-yl)-6-methyl-pyrimidin ; 4-Methoxy-2-(5-methoxy-3-methyl-1h-pyrazol-1-yl)-6-methylpyrimidine ; 4-Methoxy-2-(5-methoxy-3-methylpyrazol-1-yl)-6-methylpyrimidin ; Da-398 ; Mebron .

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