Ethyl 3-ethoxypropionate supplier

Name
Ethyl-3-ethoxypropanoate
EINECS 212-112-9
CAS No. 763-69-9
Article Data51
CAS DataBase
Density 0.949 g/cm³
Solubility 1.6 g/100 mL (20 ºC) in water
Melting Point -75 ºC
Formula C₇H₁₄O₃
Boiling Point 166.2 ºC at 760 mmHg
Molecular Weight 146.186
Flash Point 52.2 ºC
Transport Information UN 3272 3/PG 3
Appearance clear, colorless liquid
Safety 25
Risk Codes 10-19-36-50
Molecular Structure
Hazard Symbols Xi,N
Synonyms 4-03-00-00697 (Beilstein Handbook Reference);AI3-03254;BRN 1751976;Ethoxypropionic acid, ethyl ester;Ethyl beta-ethoxypropionate;
PSA 35.53000
LogP 0.97610

Synthetic route

: 64-17-5
ethanol

: 140-88-5
ethyl acrylate

: 763-69-9
ethyl 3-ethoxypropionate

Conditions

Conditions	Yield
With quaternary ammonium salt anion exchange resin In water at 30℃; for 4h; Temperature; Inert atmosphere;	98%
With triethylamine at 20℃; for 8h; Reagent/catalyst; Large scale;	98%
With aluminum oxide; potassium fluoride In acetonitrile at 20℃; for 18h; Michael addition reaction;	90%

: 141-52-6
sodium ethanolate

: 140-88-5
ethyl acrylate

: 763-69-9
ethyl 3-ethoxypropionate

Conditions

Conditions	Yield
In ethanol at 40℃; for 3h; Inert atmosphere;	97.6%

: 462-95-3
formaldehyde diethyl acetal

: 763-69-9
ethyl 3-ethoxypropionate

Conditions

Conditions	Yield
With sulfuric acid; acetic anhydride	92%

: 917-58-8
potassium ethoxide

: 140-88-5
ethyl acrylate

: 763-69-9
ethyl 3-ethoxypropionate

Conditions

Conditions	Yield
With 10H-phenothiazine In methanol at 40 - 100℃; for 2h;	86%

: 64-17-5
ethanol

: 3586-58-1
2-methylenebutyric acid

: 763-69-9
ethyl 3-ethoxypropionate

Conditions

Conditions	Yield
With 10H-phenothiazine; potassium ethoxide at 40 - 80℃; for 2h; Reagent/catalyst;	86%

: 78097-85-5
ethyl 2-bromo-3-ethoxypropanoate

: 763-69-9
ethyl 3-ethoxypropionate

Conditions

Conditions	Yield
With sodium diethyl phosphate for 5h; Ambient temperature;	72%

: 141-52-6
sodium ethanolate

: 111-13-7
hexyl-methyl-ketone

: 140-88-5
ethyl acrylate

A: 763-69-9
ethyl 3-ethoxypropionate

B: 63649-30-9
4-pentyl-1,3-cyclohexanedione

Conditions

Conditions	Yield
In tetrahydrofuran at 20℃; for 1h;	A 30% B 58%

...Expand

: 67-64-1
acetone

: 140-88-5
ethyl acrylate

A: 763-69-9
ethyl 3-ethoxypropionate

B: 1335209-87-4
ethyl 3-(2,4-dioxocyclohexyl)propanoate

C: 504-02-9
1,3-cylohexanedione

Conditions

Conditions	Yield
With sodium hydride In toluene at -10 - 20℃; for 2h; Michael-Claisen cyclization; Inert atmosphere; regioselective reaction;	A 8% B 54% C 3%
With sodium hydride at -10 - 20℃; for 0.0833333h; Michael-Claisen cyclization; Inert atmosphere; neat (no solvent); regioselective reaction;	A 6% B 39% C 9%

...Expand

: 83747-24-4
2-(2'-Ethoxycarbonylethyl)-saccharin

: 141-52-6
sodium ethanolate

A: 763-69-9
ethyl 3-ethoxypropionate

B: 81-07-2
saccharin

Conditions

Conditions	Yield
In ethanol Heating;	A n/a B 50%

...Expand

: 57-57-8
β-Propiolactone

: 64-17-5
ethanol

: 763-69-9
ethyl 3-ethoxypropionate

Conditions

Conditions	Yield
With sulfuric acid
(i), (ii) (esterification); Multistep reaction;

: 539-74-2
Ethyl 3-bromopropionate

: 141-52-6
sodium ethanolate

: 763-69-9
ethyl 3-ethoxypropionate

: 6414-69-3
ethyl 3-iodopropanoate

: 141-52-6
sodium ethanolate

: 763-69-9
ethyl 3-ethoxypropionate

Conditions

Conditions	Yield
With diethyl ether

: 141-52-6
sodium ethanolate

: 623-71-2
ethyl 3-chloropropanoate

: 763-69-9
ethyl 3-ethoxypropionate

: 64-17-5
ethanol

: 2141-62-0
3-(ethoxy)propionitrile

: 763-69-9
ethyl 3-ethoxypropionate

Conditions

Conditions	Yield
With sulfuric acid
With sulfuric acid

: 462-95-3
formaldehyde diethyl acetal

: 5764-82-9
bromo(2-ethoxy-2-oxoethyl)zinc

: 763-69-9
ethyl 3-ethoxypropionate

Conditions

Conditions	Yield
With acetyl chloride

: 64-17-5
ethanol

: 89181-45-3
1,1,1-trichloro-3-ethoxy-propane

: 763-69-9
ethyl 3-ethoxypropionate

Conditions

Conditions	Yield
With potassium hydroxide

: 64-17-5
ethanol

: 3-Bromo-propionimidic acid ethyl ester; hydrochloride

: 763-69-9
ethyl 3-ethoxypropionate

: 22409-91-2
3-phenoxypropionic acid ethyl ester

: 141-52-6
sodium ethanolate

: 763-69-9
ethyl 3-ethoxypropionate

Conditions

Conditions	Yield
In ethanol

: 140-88-5
ethyl acrylate

: 763-69-9
ethyl 3-ethoxypropionate

Conditions

Conditions	Yield
With tetraethylammoniumcyanide In acetonitrile

: 78-94-4
methyl vinyl ketone

: 140-88-5
ethyl acrylate

: 763-69-9
ethyl 3-ethoxypropionate

Conditions

Conditions	Yield
With sodium hydroxide; cetyltrimethylammonim bromide In dichloromethane	70 % Chromat.

: 64-17-5
ethanol

: 140-88-5
ethyl acrylate

A: 6317-49-3
4-oxopimelate

B: 763-69-9
ethyl 3-ethoxypropionate

C: 105-37-3
Ethyl propionate

D: 4-Ethoxycarbonyl-4-methyl-5-oxo-octanedioic acid diethyl ester

Conditions

Conditions	Yield
With potassium tetracarbonylhydridoferrate at 70℃; for 30h;	A 3 mmol B 3 mmol C 27 mmol D n/a
With potassium tetracarbonylhydridoferrate at 70℃; for 30h;	A n/a B 3 mmol C 27 mmol D 3 mmol

...Expand

: 64-17-5
ethanol

: 140-88-5
ethyl acrylate

A: 6317-49-3
4-oxopimelate

B: 763-69-9
ethyl 3-ethoxypropionate

C: 105-37-3
Ethyl propionate

D: 609-08-5
Diethyl methylmalonate

Conditions

Conditions	Yield
With potassium tetracarbonylhydridoferrate at 70℃; for 30h; Product distribution; time, atmosphere;

...Expand

: 141-52-6
sodium ethanolate

: 140-88-5
ethyl acrylate

A: 763-69-9
ethyl 3-ethoxypropionate

B α-methylene-glutaric acid diethyl ester: α-methylene-glutaric acid diethyl ester

Conditions

Conditions	Yield
at 80 - 100℃; und Behandeln mit kalter verd.Saeure;

...Expand

: 109-95-5
ethyl nitrite

3-amino-propionic acid-hydrochloride: 3-amino-propionic acid-hydrochloride

: 763-69-9
ethyl 3-ethoxypropionate

Conditions

Conditions	Yield
With ethanol at 95 - 105℃; unter Druck;

: 64-17-5
ethanol

: 140-88-5
ethyl acrylate

A: 1001-26-9
ethyl 3-ethoxyacrylate

B: 763-69-9
ethyl 3-ethoxypropionate

C: 10601-80-6
ethyl 3,3-diethoxypropanoate

Conditions

Conditions	Yield
With carbon dioxide; oxygen; copper(l) chloride; dichloro bis(acetonitrile) palladium(II) at 40℃; under 97507.8 Torr; for 12h;	A 6.0 % Chromat. B 5.6 % Chromat. C 75.8 % Chromat.

...Expand

: 64-17-5
ethanol

: 503-66-2
3-hydroxypropionic acid

: 763-69-9
ethyl 3-ethoxypropionate

Conditions

Conditions	Yield
sodium hydroxide In water at 220℃; under 2585.81 Torr; for 1.6h; Product distribution / selectivity;	5 - 50 %Chromat.
calcium hydroxide In water at 220℃; under 2585.81 Torr; for 1.6h; Product distribution / selectivity;	5 - 50 %Chromat.
magnesium hydroxide In water at 220℃; under 2585.81 Torr; for 1.6h; Product distribution / selectivity;	5 - 50 %Chromat.

: 89180-39-2
3-bromo-1,1,1-trichloro-3-ethoxy-propane

: 763-69-9
ethyl 3-ethoxypropionate

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: LiAlH4 / diethyl ether 2: aq. KOH View Scheme

: 763-69-9
ethyl 3-ethoxypropionate

: 109-94-4
formic acid ethyl ester

: trans-2-Ethoxymethylen-3-ethoxy-propionsaeure-ethylester

Conditions

Conditions	Yield
Stage #1: ethyl 3-ethoxypropionate; formic acid ethyl ester With sodium ethanolate In tetrahydrofuran at 20℃; for 1h; Stage #2: With dimethyl sulfate In tetrahydrofuran at 50℃; for 2h;	100%

: 763-69-9
ethyl 3-ethoxypropionate

: 1133-12-6
N-propyl-toluene-4-sulfonamide

: 1391911-31-1
C15H25NO3S

Conditions

Conditions	Yield
With 1,1,3,3-Tetramethyldisiloxane; (Ace)Ru3(CO)7 In dichloromethane at 20℃; for 20h; Inert atmosphere;	99%

: 763-69-9
ethyl 3-ethoxypropionate

: 1576-37-0
N-benzyl-p-toluenesulfonamide

: 1391911-32-2
C19H25NO3S

Conditions

Conditions	Yield
With 1,1,3,3-Tetramethyldisiloxane; (Ace)Ru3(CO)7 In dichloromethane at 20℃; for 20h; Inert atmosphere;	99%

: 763-69-9
ethyl 3-ethoxypropionate

: 106011-68-1
4-methyl-N-pentylbenzenesulfonamide

: 1394028-60-4
C17H29NO3S

Conditions

Conditions	Yield
With 1,1,3,3-Tetramethyldisiloxane; (Ace)Ru3(CO)7 In dichloromethane at 20℃; for 20h; Inert atmosphere;	99%

: 763-69-9
ethyl 3-ethoxypropionate

: 78388-19-9
4-methyl-N-(3-methylbut-2-enyl)benzenesulfonamide

: 1394028-61-5
C17H27NO3S

Conditions

Conditions	Yield
With 1,1,3,3-Tetramethyldisiloxane; (Ace)Ru3(CO)7 In dichloromethane at 20℃; for 20h; Inert atmosphere;	99%

: 763-69-9
ethyl 3-ethoxypropionate

: 640-61-9
N-methyl-p-toluenesulfonylamide

: 1391911-30-0
C13H21NO3S

Conditions

Conditions	Yield
With 1,1,3,3-Tetramethyldisiloxane; (Ace)Ru3(CO)7 In dichloromethane at 20℃; for 20h; Inert atmosphere;	99%

: 763-69-9
ethyl 3-ethoxypropionate

: 37952-36-6
3-Ethoxypropionsaeurehydrazid

Conditions

Conditions	Yield
With hydrazine In ethanol; water Reflux;	85%

: 108-86-1
bromobenzene

: 763-69-9
ethyl 3-ethoxypropionate

: 3-ethoxy-1,1-diphenylpropan-1-ol

Conditions

Conditions	Yield
With magnesium; copper(II) oxide In tetrahydrofuran at 65℃; for 4h; Barbier Coupling Reaction; chemoselective reaction;	83%
With magnesium; copper(II) oxide In tetrahydrofuran at 65℃; for 4h; chemoselective reaction;	83%

: 763-69-9
ethyl 3-ethoxypropionate

: 106-38-7
para-bromotoluene

: 1541189-44-9
3-ethoxy-1,1-di(p-tolyl)propan-1-ol

Conditions

Conditions	Yield
With magnesium; copper(II) oxide In tetrahydrofuran at 65℃; for 4h; Barbier Coupling Reaction; chemoselective reaction;	77%
With magnesium; copper(II) oxide In tetrahydrofuran at 65℃; for 4h; chemoselective reaction;	77%

: 452-58-4
2,3-Diaminopyridine

: 763-69-9
ethyl 3-ethoxypropionate

: 1235235-73-0
2-(2-ethoxyethyl)-3H-imidazo[4,5-b]pyridine

Conditions

Conditions	Yield
With lithium bromide at 110 - 115℃; for 9h; Neat (no solvent);	75%

: 763-69-9
ethyl 3-ethoxypropionate

: 70-55-3
toluene-4-sulfonamide

: 1391911-29-7
C17H29NO4S

Conditions

Conditions	Yield
With 1,1,3,3-Tetramethyldisiloxane; (Ace)Ru3(CO)7 In dichloromethane at 20℃; for 20h; Inert atmosphere;	72%

: 763-69-9
ethyl 3-ethoxypropionate

: 95-54-5
1,2-diamino-benzene

: 51036-80-7
2-(2-ethoxy-ethyl)-1H-benzimidazole

Conditions

Conditions	Yield
With lithium bromide at 110 - 115℃; for 10h; Neat (no solvent);	70%
With hydrogenchloride

: 763-69-9
ethyl 3-ethoxypropionate

: 74-95-3
1,2-dibromomethane

: 1,1-dibromo-4-ethoxy-2-butanone

Conditions

Conditions	Yield
With 2,2,6,6-tetramethyl-piperidine; n-butyllithium In tetrahydrofuran; hexane at -78℃; for 0.166667h;	67%

: 110-91-8
morpholine

: 763-69-9
ethyl 3-ethoxypropionate

: β-ethoxy-N-morpholinylpropionamide

Conditions

Conditions	Yield
With iron(II) triflate at 0 - 80℃; under 760.051 Torr; for 1h; Autoclave;	62%

: 763-69-9
ethyl 3-ethoxypropionate

: 77-78-1
dimethyl sulfate

: 109-94-4
formic acid ethyl ester

: 2974-30-3
(Z)-ethyl-2-(ethoxymethyl)-3-methoxyacrylate

Conditions

Conditions	Yield
Stage #1: ethyl 3-ethoxypropionate; formic acid ethyl ester With ethanol; sodium In benzene at 0℃; for 2h; Claisen condensation; Stage #2: dimethyl sulfate In benzene at 50℃; for 3h;	58%
Stage #1: ethyl 3-ethoxypropionate; formic acid ethyl ester With sodium ethanolate In toluene at 0℃; for 2h; Inert atmosphere; Stage #2: dimethyl sulfate In toluene at 0 - 50℃; for 12h; Inert atmosphere;	52%
Stage #1: ethyl 3-ethoxypropionate; formic acid ethyl ester With ethanol; sodium In benzene at 0 - 20℃; for 2h; Stage #2: dimethyl sulfate In benzene at 50℃; for 3h; Stage #3: With triethylamine hydrochloride; sodium hydroxide In benzene for 4h;	33%
(i) NaOEt, EtOH, (ii) /BRN= 635994/; Multistep reaction;
Stage #1: ethyl 3-ethoxypropionate; formic acid ethyl ester With sodium In ethanol; benzene at 0℃; for 2h; Stage #2: dimethyl sulfate In ethanol; benzene at 50℃; for 3h;

...Expand

: 763-69-9
ethyl 3-ethoxypropionate

: 109-94-4
formic acid ethyl ester

: (Z)-ethyl-2-(ethoxymethyl)-3-methoxyacrylate

Conditions

Conditions	Yield
Stage #1: ethyl 3-ethoxypropionate; formic acid ethyl ester With sodium In ethanol; hexane at 0 - 20℃; for 3h; Stage #2: With triethylamine hydrochloride; sodium hydroxide at 20℃; for 4h;	56%

: 109-04-6
2-bromo-pyridine

: 763-69-9
ethyl 3-ethoxypropionate

: 3-ethoxy-1-(pyridin-2-yl)propan-1-one

Conditions

Conditions	Yield
Stage #1: 2-bromo-pyridine With n-butyllithium In diethyl ether; hexane at -78℃; for 0.5h; Stage #2: ethyl 3-ethoxypropionate In diethyl ether; hexane at -78℃; for 1h;	54%
Stage #1: 2-bromo-pyridine With n-butyllithium In diethyl ether; hexane at -78℃; for 0.5h; Stage #2: ethyl 3-ethoxypropionate In diethyl ether; hexane at -78℃; for 1h;	54%

: 763-69-9
ethyl 3-ethoxypropionate

A: 924-44-7
glyoxylic acid ethyl ester

B: 34780-29-5
3-oxo-propionic acid ethyl ester

C: 75-07-0
acetaldehyde

D: 3-Formyloxy-propionic acid ethyl ester

E: 109-94-4
formic acid ethyl ester

Conditions

Conditions	Yield
With dodecane; methyl nitrite; nitrogen(II) oxide at 23.9℃; under 760 Torr; Rate constant; Product distribution; Mechanism; Irradiation;	A 25% B 4.8% C 4.9% D 30% E 37%

...Expand

: 763-69-9
ethyl 3-ethoxypropionate

: 77-78-1
dimethyl sulfate

: 109-94-4
formic acid ethyl ester

: 879008-23-8
(Z)-ethyl-2-(ethoxymethyl)-3-methoxyacrylate

Conditions

Conditions	Yield
Stage #1: ethyl 3-ethoxypropionate; formic acid ethyl ester With sodium In ethanol; hexane at 0 - 20℃; Stage #2: dimethyl sulfate In hexane at 50℃; for 2h; Cooling with ice; Stage #3: With triethylamine hydrochloride; sodium hydroxide In hexane at 20℃; for 4h;	37%
Stage #1: ethyl 3-ethoxypropionate; formic acid ethyl ester With ethanol; sodium In hexane at 0 - 20℃; Stage #2: dimethyl sulfate In hexane at 50℃; for 2h; Cooling with ice;	37%
Stage #1: ethyl 3-ethoxypropionate; formic acid ethyl ester With ethanol; sodium In benzene at 0℃; for 2h; Stage #2: dimethyl sulfate In benzene at 50℃; for 3h; Stage #3: With triethylamine hydrochloride; sodium hydroxide In benzene for 4h;	33%
Stage #1: ethyl 3-ethoxypropionate; dimethyl sulfate; formic acid ethyl ester With ethanol; sodium In benzene at 0 - 50℃; for 5h; Stage #2: With triethylamine hydrochloride; sodium hydroxide In benzene for 4h;	33%
Stage #1: ethyl 3-ethoxypropionate; formic acid ethyl ester With sodium ethanolate In hexane at 0 - 20℃; Stage #2: dimethyl sulfate In hexane at 50℃; for 2h; Cooling with ice;

...Expand

: 211245-64-6
4-cyclopentylamino-2-methylsulfanyl-pyrimidine-5-carbaldehyde

: 763-69-9
ethyl 3-ethoxypropionate

: 571189-94-1
8-cyclopentyl-6-ethoxymethyl-2-methylsulfanyl-8H-pyrido[2,3-d]pyrimidin-7-one

Conditions

Conditions	Yield
Stage #1: ethyl 3-ethoxypropionate With lithium hexamethyldisilazane In tetrahydrofuran Stage #2: 4-cyclopentylamino-2-methylsulfanyl-pyrimidine-5-carbaldehyde In tetrahydrofuran for 24h;	35%
In tetrahydrofuran; ethyl acetate	34.9%

: 763-69-9
ethyl 3-ethoxypropionate

: 77-78-1
dimethyl sulfate

: 109-94-4
formic acid ethyl ester

: (z)-ethyl-2-(ethoxymethyl)-3-methoxyacrylate

Conditions

Conditions	Yield
Stage #1: ethyl 3-ethoxypropionate; formic acid ethyl ester With ethanol; sodium In benzene at 0 - 20℃; for 2h; Stage #2: dimethyl sulfate In benzene at 50℃; for 3h; Stage #3: With sodium hydroxide; water; triethylamine hydrochloride In benzene for 4h;	33%

...Expand

Ethyl 3-ethoxypropionate Consensus Reports

Reported in EPA TSCA Inventory.

Ethyl 3-ethoxypropionate Specification

The Ethyl .beta.-ethoxypropionate, with the CAS registry number 763-69-9, has the IUPAC name of ethyl 3-ethoxypropanoate. For a kind of clear liquid with an ester-like odor, this chemical is stable under normal temperatures and pressures but incompatibilities with strong oxidizing agents and it could react with acids to liberate heat along with alcohols and acids.

The characteristics of this chemical are as below: (1)ACD/LogP: 1.25; (2)# of Rule of 5 Violations: 0; (3)ACD/LogD (pH 5.5): 1.25; (4)ACD/LogD (pH 7.4): 1.25; (5)ACD/BCF (pH 5.5): 5.25; (6)ACD/BCF (pH 7.4): 5.25; (7)ACD/KOC (pH 5.5): 113.99; (8)ACD/KOC (pH 7.4): 113.99; (9)#H bond acceptors: 3; (10)#H bond donors: 0; (11)#Freely Rotating Bonds: 6; (12)Polar Surface Area: 35.53; (13)Index of Refraction: 1.408; (14)Molar Refractivity: 37.99 cm³; (15)Molar Volume: 153.9 cm³; (16)Polarizability: 15.06 ×10^-24 cm³; (17)Surface Tension: 28.3 dyne/cm; (18)Density: 0.949 g/cm³; (19)Flash Point: 52.2 °C; (20)Enthalpy of Vaporization: 40.27 kJ/mol; (21)Boiling Point: 166.2 °C at 760 mmHg; (22)Vapour Pressure: 1.8 mmHg at 25°C; (23)Exact Mass: 146.094294; (24)MonoIsotopic Mass: 146.094294; (25)Topological Polar Surface Area: 35.5; (26)Heavy Atom Count: 10; (27)Complexity: 90.9.

When you are dealing with this chemical, you should be careful. For one part, it is irritant which may cause inflammation to the skin or other mucous membranes. And it is irritating to eyes and may then cause explosive peroxides. For another part, it is dangerous for the environment which may present an immediate or delayed danger to one or more components of the environment. When you are contacting, avoid contacting with eyes directly.

In addition, you could convert the following datas into the molecular structure:
(1)Canonical SMILES: CCOCCC(=O)OCC
(2)InChI: InChI=1S/C7H14O3/c1-3-9-6-5-7(8)10-4-2/h3-6H2,1-2H3
(3)InChIKey: BHXIWUJLHYHGSJ-UHFFFAOYSA-N

Below are the toxicity information of this chemical:

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
rabbit	LD50	skin	10mL/kg (10mL/kg)		AMA Archives of Industrial Hygiene and Occupational Medicine. Vol. 4, Pg. 119, 1951.
rat	LD50	oral	5gm/kg (5000mg/kg)		AMA Archives of Industrial Hygiene and Occupational Medicine. Vol. 4, Pg. 119, 1951.

Product Name

Ethyl-3-ethoxypropanoate

Synthetic route

Ethyl 3-ethoxypropionate Consensus Reports

Ethyl 3-ethoxypropionate Specification

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